DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo95E and Myo1f

DIOPT Version :9

Sequence 1:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001101546.1	Gene:	Myo1f / 314654	RGDID:	1309750	Length:	1098	Species:	Rattus norvegicus

Alignment Length:	1340	Identity:	301/1340 - (22%)
Similarity:	498/1340 - (37%)	Gaps:	485/1340 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QEIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGI 67
            ::.|..|.|||..::||:.::|:.:|:..|:|:||||:.::::||:..:...:...:..|.....
  Rat    15 KQSGVDDMVLLPQITEDAIVSNLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGAAQ 79

  Fly    68 FQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLR 132
            ::.|||||.||:..|:::....|:|||:::||||||||...|.|:.:::.:.
  Rat    80 YENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVS------------- 131

  Fly   133 KQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIE 197

  Rat   132 ----------------------------------------------------------------- 131

  Fly   198 RQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPK 262

  Rat   132 ----------------------------------------------------------------- 131

  Fly   263 YAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHS 327
                   ||..:..|.|.:..||                        ||
  Rat   132 -------GGGDKVQHVKDIILQS------------------------NP---------------- 149

  Fly   328 TESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRM 392

  Rat   150 ----------------------------------------------------------------- 149

  Fly   393 RECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGER 457
                     .|||.|||.|::||||||:||.|:|:....|:|.|..|::::|||:|:......||
  Rat   150 ---------LLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNENER 205

  Fly   458 NFHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAMEE---DRMNFHYTKRSLDVLGLSCEES 519
            ||||:||||.||..:..::|.|......|.|.::.|...|   ||.:|:.|..::.|:|:.....
  Rat   206 NFHIYYQLLEGASQEQQQNLGLMTPDYYYYLNQSDTYKVEGTDDRSDFNETLNAMQVIGIPTSVQ 270

  Fly   520 NSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQET------AQLLNMEAQILINCLTRA 578
            ..:.:::|.:|.|||..|           |:..|...|:..      |.||.:::..|...||..
  Rat   271 QLVLQLVAGILHLGNISF-----------CEEGNYARVESVDLLAFPAYLLGIDSGRLQEKLTSR 324

  Fly   579 ---NSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQREKNLALLDFYG 640
               :......|.:...::..|||..|:.|.:.||:|||.:||..||.:::..|.|.::.:||.||
  Rat   325 KMDSKWGGRSESIDVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQKPQEEYSIGVLDIYG 389

  Fly   641 FEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELID---KP 702
            ||....|.||||.||:..||:.|.|:...|::|||.|::||:.|:.|:||:|:.:|:||:   .|
  Rat   390 FEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKLNP 454

  Fly   703 SYGILSLINE----PHLNSNDA---LLLRVQQCCAGHPNFMTTGSNSMCFQIRHYASVVNYSIHR 760
            . ||:|::::    .|.....|   ||.::|.....|.:|   .|.|..|.|.|||..|:|.:..
  Rat   455 P-GIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHF---NSWSAGFVIHHYAGKVSYDVSG 515

  Fly   761 FLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKK--PSTLSSNIRTQLQTLLAIVKHR 823
            |.|:|.|:|...:......|..:.::.||||   :..|.||  |||..|.|:.|...|::.:|..
  Rat   516 FCERNRDVLFSDLIELMQSSDQAFLRMLFPE---KLDVDKKGRPSTAGSKIKKQANDLVSTLKKC 577

  Fly   824 RSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTW 888
            ..||:.||||||.|:|..::.:.|:|||.|:.|...:.:.|.|..|.....||..||.:|...||
  Rat   578 TPHYIRCIKPNETKRPRDWEESRVKHQVEYLGLRENIRVRRAGFAYRRQFSKFLQRYAILTPETW 642

  Fly   889 PHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRM 953
            |.:.|..: :|:..::|.:.:...::.:|:..|||::|.:::.||:.|..:....|..||
  Rat   643 PRWRGDER-QGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEMRERKFDGFARTIQ----- 701

  Fly   954 YHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAIDI 1018
                              .||              |||:
  Rat   702 ------------------KAW--------------RRHI-------------------------- 708

  Fly  1019 IGRYYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIYHRWKCYIYRNSFDQ 1083
                    .:|::
  Rat   709 --------AVRKY---------------------------------------------------- 713

  Fly  1084 TARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAETNDQYVVFADIINKI 1148
               ..|||:  ||.|..::|.....|:...|||||:.|....:.::..|:.  :.|.|||.:.|.
  Rat   714 ---EEMREE--ASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLAKR--ERVDFADSVTKY 771

  Fly  1149 ARSSGKFVPIL--LVLSTSSLLLLDQRTLQ-----------IKYRVPASEIYRMSLSPYLDDIAV 1200
            .|   :|.||.  |:|:...:.::.:..::           :|.::....:..:|||...||..:
  Rat   772 DR---RFKPIKRDLILTPKCVYVIGREKVKKGPEKGLVREVLKKKLEIQALRGVSLSTRQDDFFI 833

  Fly  1201 FHVKASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGKP-P-------EIHISTEFEANFGQQT 1257
            ...:|::...:.   :|:| ..:.::.|.|   :.|..:| |       :..:..|.......:.
  Rat   834 LQEEAADSFLES---IFKT-EFVSLLCKRF---EEAARRPLPLTFSDMLQFRVKKEGWGGGSTRN 891

  Fly  1258 VIFSFKYGGMSDLA--------------QGPPKVTRKANR 1283
            |.||   .|..|||              .|.||.|:...:
  Rat   892 VTFS---RGTGDLAVLKAGSRALTISIGDGLPKSTKPTRK 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	34/98 (35%)
		Motor_domain	403..924	CDD:277568	187/544 (34%)
		Myosin_TH1	1092..1267	CDD:283635	41/195 (21%)
Myo1f	NP_001101546.1	MYSc	12..690	CDD:214580	239/957 (25%)
		MYSc_Myo1	31..677	CDD:276829	229/928 (25%)
		Myosin_TH1	717..899	CDD:283635	44/198 (22%)
		SH3_MyoIe_If_like	1045..1097	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820