Protein Alignment Myo95E and Myo9a

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_006511271.1
• Gene: Myo9a / 270163
• MGIID: 107735
• Length: 2633
• Species: Mus musculus
• Alignment Length: 1303
• Identity: 247/1303 - (18%)
• Similarity: 412/1303 - (31%)
• Gaps: 575/1303 - (44%)

  Fly     9 DSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQLPPH 73
            |...|.:|:|.:.:.|:..|:|.:.||||:|:.::|:||:..:..::...|:.|.:..:.:|.||
Mouse   150 DLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIAINPFKFLPIYNPKYVKMYDNHQLGKLEPH 214

  Fly    74 IYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSSTS 138
            ||.:.::||.::..:.::||::::||||:|||::    .|||.|     |       |...|...
Mouse   215 IYAVADVAYHAMLQRKKNQCIVISGESGSGKTQS----TNFLIH-----H-------LTALSQKG 263

  Fly   139 SASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSRRH 203
            .|||:
Mouse   264 FASGV------------------------------------------------------------ 268

  Fly   204 MREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVPTV 268
              |:|
Mouse   269 --EQI------------------------------------------------------------ 271

  Fly   269 YGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQPE 333
                                                                             
Mouse   272 ----------------------------------------------------------------- 271

  Fly   334 RERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECVTC 398
                                     :||
Mouse   272 -------------------------ILG------------------------------------- 274

  Fly   399 ADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHIFY 463
            |...|||.|||.|..||||||:||...:.....|..:|.::..|:|||:|:......|||:|:||
Mouse   275 AGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFY 339

  Fly   464 QLLLGADLQLLKSLKLYRNVEKYELLRNTTAM-----------------------EEDRMNFHYT 505
            .||.||..:...:..| :..|:|..|...|..                       |:.|.:|...
Mouse   340 YLLAGASEEERLAFHL-KQPEEYHFLNQITKKPLRQSWDDYCYDSEPQDCFTVEGEDLRHDFERL 403

  Fly   506 KRSLDVLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQI 570
            :.:::::|...:....||.:::.:|.|||..:...|..|  :...:.|...:...::||.::.::
Mouse   404 QLAMEMVGFLPKTRRQIFSLLSAILHLGNISYKKKTYRD--DSIDICNPEVLPIVSELLEVKEEM 466

  Fly   571 LINCLTRANSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKST----QREK 631
            |...|. ...|.:..|.:.......:|.|.||::.::|||.||.|:|.:||.:|.::    |..|
Mouse   467 LFEALV-TRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEQDTK 530

  Fly   632 NLAL--LDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNES 694
            .|::  ||.:|||..::||||||.||::.|::...|..|:.:.|||.|..||:.|..|||.||..
Mouse   531 TLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTC 595

  Fly   695 ICELIDKPSYGILSLINE----PHLNSNDALLLRVQQCCAGHPNFMTTGSNSMCFQIRHYASVVN 755
            ...||.|...|:|.|::|    |.. :|..||.:.:.....:............|.|:|||..|.
Mouse   596 CINLISKKPTGLLHLLDEESNFPQA-TNQTLLDKFKHQHEENSYIEFPAVMEPAFIIKHYAGKVK 659

  Fly   756 YSIHRFLEKNSD-MLPKYIS----------------------------------AAF-------- 777
            |.:..|.|||:| |.|..::                                  .||
Mouse   660 YGVKDFREKNTDHMRPDIVALLRSSRNAFVSGMTGIDPVAVFRWAVLRAFFRAVVAFREAGKRHI 724

  Fly   778 ----------------------------YQSKLSLVQSLFPE------GNPRRQVT--------- 799
                                        :|..|.::|....|      .|||..::
Mouse   725 QRKSGHDDTTPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNTLN 789

  Fly   800 ----------------------------------------------------------------- 799
                                                                             
Mouse   790 EKNQHDTFDIAWNVRTGIRQSRLPASNTSLLDKDGIFAHSASSKLLERAHGILTRNKNFRSKPVL 854

  Fly   800 --------------------------------KKPSTLSSNIRTQLQTLLAIVKHRRSHYVFCIK 832
                                            |||.::|:..:..|..|:..:.....::|.||:
Mouse   855 PKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAEPYFVKCIR 919

  Fly   833 PNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWPHFHGGSQV 897
            .|..|.|.:|..|||..|:||..::..|.:.::|         :..:|...:.::  |||
Mouse   920 SNAEKLPLRFSDALVLRQLRYTGMLETVRIRQSG---------YSSKYSFQDFVS--HFH----- 968

  Fly   898 EGIAL-------------IIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISEL---AVL 946
              :.|             ..|.:.:.|..:.:|...||::.    :|.:..:.|...|:   .||
Mouse   969 --VLLPQHIIPSKFNIQDFFRKININSDNYQVGKTMVFLKE----HERQHLQDLLHQEVLRRIVL 1027

  Fly   947 IQTMFRMYHARKRFQRMRHSQMIISSAWR-----------------------------TWR---- 978
            :|..||:..:|::|..:|.:.:||...||                             :||
Mouse  1028 LQRWFRVLLSRQQFLHLRQASIIIQRFWRNYLNQKQVRNAAVEKDAFIMASAASLLQASWRAHLE 1092

  Fly   979 -----ECRFGIPFTGRRHLW-SLYRVAREE----------YRSLKYKRQVRWAIDIIGRYYRQWK 1027
                 |.|.......:|  | .|||...:.          ||..|..::.|..|.::...||.::
Mouse  1093 RQRYLELRAAAVIIQQR--WRELYRCRHKAATCIQSRWRGYRQRKKYKEQRNKIILLQSIYRGFR 1155

  Fly  1028 IRQ 1030
            .||
Mouse  1156 ARQ 1158

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	37/113 (33%)
		Motor_domain	<403..937	CDD:473979	167/762 (22%)
		Myosin_TH1	1092..1288	CDD:461801
Myo9a	XP_006511271.1	RA_Myosin-IXa	15..110	CDD:340736
		MYSc_Myo9	160..1006	CDD:276836	210/1133 (19%)
		IQ	1117..1138	CDD:197470	3/20 (15%)
		C1_Myosin-IXa	2070..2127	CDD:410433
		RhoGAP_myosin_IX	2136..2321	CDD:239842