DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo95E and Myo81F

DIOPT Version :9

Sequence 1:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001303492.1	Gene:	Myo81F / 26067052	FlyBaseID:	FBgn0267431	Length:	2082	Species:	Drosophila melanogaster

Alignment Length:	1378	Identity:	312/1378 - (22%)
Similarity:	513/1378 - (37%)	Gaps:	462/1378 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QEIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGI 67
            :.:|..|...:..:.|.....|::.||..|.||||.|:.::|:|||..|:..:...:..|....:
  Fly     6 RRVGFADMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKL 70

  Fly    68 FQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLR 132
            ..|.||::.:...||.|:.|.:.:|..:::|||||||||:.|.|:.:|        |..|.||
  Fly    71 GDLSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYL--------CTITSNV-- 125

  Fly   133 KQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIE 197

  Fly   126 ----------------------------------------------------------------- 125

  Fly   198 RQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPK 262

  Fly   126 ----------------------------------------------------------------- 125

  Fly   263 YAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHS 327
                           |..|:.|.||
  Fly   126 ---------------SSWVQQQILE---------------------------------------- 135

  Fly   328 TESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRM 392

  Fly   136 ----------------------------------------------------------------- 135

  Fly   393 RECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGER 457
                  |:..|||.|||.|.:|:||||:||...:..|......|..|..|:||::|||....|||
  Fly   136 ------ANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGER 194

  Fly   458 NFHIFYQLLLGA--DLQLLKSLKLYRNVEKYELLRNTTAMEEDRMN-----FHYTKRSLDVLGLS 515
            |:||.|||:...  ::.:..:..| |..|.|:.| ||:..|:..||     |.....:..||.:.
  Fly   195 NYHIMYQLVAQGQKNIGIANTFHL-RPAEFYKYL-NTSNSEKINMNLESKKFDAVTMAFTVLQIP 257

  Fly   516 CEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEV-QETAQLLNM---------EAQI 570
            ....:.:|:||:.:|.|||..|:   ::||    :|:::... ||...:::|         :..:
  Fly   258 QFVIDGVFKVISSILWLGNIEFI---DVDG----EVTDLTRSDQEAISIISMLLGLSRCDFKKVL 315

  Fly   571 LINCL-TRANSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQRE-KNL 633
            ||..: .|.|.|.       ..:..::|..||:.|.:.|||::|||||:|||......|.: |.|
  Fly   316 LIRQINVRGNITE-------IPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKFL 373

  Fly   634 ALLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICEL 698
            .:||.:|||...||||||..|||:.||:|:.|..:|...||.:|..||:.::.:::.||....|:
  Fly   374 GVLDIFGFENFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEI 438

  Fly   699 IDKPSYGILSLINEP-HL--NSNDALLLRVQQCCAGHPNFMTTGSN----SMCFQIRHYASVVNY 756
            ::||...:..|:.|. |:  .|:.|.|..:......|||:: .||:    ...|.|:|||.:|.|
  Fly   439 LEKPPRCVFKLLTEQCHMPQGSDLAFLSNMHTEFESHPNYI-KGSDRRHWETEFGIKHYAGLVIY 502

  Fly   757 SIHRFLEKN----SDMLPKYIS---------AAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSN 808
            ::..|:|||    .|::.:|:|         .:.||. :..:.|.:|.|:     :|...|:|.|
  Fly   503 AVGGFVEKNRDVQQDVMFEYMSYSKDVFIKDLSTYQD-IQFINSSYPRGS-----SKSKCTVSDN 561

  Fly   809 IRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLH 873
            .|.|||:|:.::::.:..||.|||||..|:|:.::.:||..|::|:.::.::.:.|.|...||.|
  Fly   562 FRNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSH 626

  Fly   874 VKFFHRYKLL---NSLTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYE-LEQ 934
            ..|..|||.|   .|..:|..:       :..|:....:|:.|:.||...:|:|:  ..|| ||.
  Fly   627 KDFIVRYKCLIKNKSFEYPQKY-------LTNILEKNGMPTTEWQIGKSKIFLRN--AAYELLET 682

  Fly   935 FRRLRISELAVLIQTMFRMYHARKRFQRMRHSQMIISSAWRTWR-ECRFGIPFTGRRHLWSLYRV 998
            .|:..:.:.||:||..::.|:.:|.|.|.:.:.:.|..|:|.|| ..||   ...||..    .|
  Fly   683 NRKDTLYKNAVIIQKNWKKYYIQKSFLRNKQAVLRIQHAYRGWRLRIRF---MRMRRSA----IV 740

  Fly   999 AREEYRSLKYKRQVRWAIDIIGRYYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASR 1063
            .:...|.: :.|:|..|:..:.|...:.|.|..:......:...||:..........:.||..|.
  Fly   741 IQSRLRGV-FAREVAAALREMKRVDEELKKRDGIYEQLTSITTKTLADCERSIQEELSVLAHISD 804

  Fly  1064 HLRSIYHRWKCYIYRNSFD-QTARNRMREK-VTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQ 1126
            ::|:   ..|....:|..| .|||:.:::. |....:|.....|.|     .|....:: ..|..
  Fly   805 NIRA---SAKPLSDKNDSDSNTARSSIKQNTVNLDNMFDFLCESKG-----AFENALIK-EINDN 860

  Fly  1127 WKK----------ICAETNDQYVVFADIINKIARSSGKFV------------------------- 1156
            |..          :|..|.|.:         .::.:||..
  Fly   861 WNNLVKNLDEEIGLCIHTEDSF---------DSQKTGKLFTTKTVRTLPEPTVPPPPPPVSISAN 916

  Fly  1157 ----PI-----LLVLSTS------SLLLLDQRTLQ------------IKYRVPASE--------- 1185
                ||     |..|:|:      ..:|||.::::            :||::...|
  Fly   917 LNSEPIYEAINLYKLTTTKEIKKEKYMLLDYKSIKDNSKKPSTSSVFVKYQIDERENRRKQRVEK 981

  Fly  1186 -IYRMSLSPYLDDIAVFHVKAS-----EFGRK-------KGDFVF-----QTGHVIEIVTKMFLV 1232
             |:.::|.....||   |:..|     ||...       ..|..|     |.|...:...|..:.
  Fly   982 KIHELTLIDIHKDI---HIDNSFYNILEFAENYFNTHDLSSDCNFISTPTQKGKSSDKTAKHEMT 1043

  Fly  1233 IQNATGKPPEIHI 1245
            :.:.:.|.|..||
  Fly  1044 MFSKSDKIPTSHI 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	35/98 (36%)
		Motor_domain	403..924	CDD:277568	181/562 (32%)
		Myosin_TH1	1092..1267	CDD:283635	40/244 (16%)
Myo81F	NP_001303492.1	MYSc	8..685	CDD:214580	234/974 (24%)
		Motor_domain	23..673	CDD:277568	226/945 (24%)
		MyTH4	1091..1194	CDD:279165
		B41	1202..1419	CDD:214604
		UBQ	1202..1297	CDD:294102
		FERM_M	1307..1419	CDD:278785
		PH-like	1415..1523	CDD:302622
		MyTH4	1664..1771	CDD:279165
		UBQ	1780..1860	CDD:294102
		B41	1781..1992	CDD:214604
		FERM_B-lobe	1893..1984	CDD:271216
		PH-like	1988..2076	CDD:302622
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010