DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo95E and myo1

DIOPT Version :9

Sequence 1:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_595402.1	Gene:	myo1 / 2539659	PomBaseID:	SPBC146.13c	Length:	1217	Species:	Schizosaccharomyces pombe

Alignment Length:	1285	Identity:	281/1285 - (21%)
Similarity:	468/1285 - (36%)	Gaps:	456/1285 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EQEIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKG 66
            ::.:|..|..||..::::....|:..|::...||||||..::::||:..:..:::|.:::|..|.
pombe    37 KKTVGVDDLTLLSKITDEEINKNLELRFRNGEIYTYIGHVLISVNPFRDLGIYTMDILKSYQGKN 101

  Fly    67 IFQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVL 131
            ..:..||:|.:...||..:|...|:||::::|||||||||..|.|:.::||:
pombe   102 RLETSPHVYAIAENAYYQMKSYHENQCIIISGESGAGKTEAAKRIMQYITHV------------- 153

  Fly   132 RKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESI 196
                                                                     |::....|
pombe   154 ---------------------------------------------------------SKSVGTEI 161

  Fly   197 ERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSP 261
            |
pombe   162 E---------------------------------------------------------------- 162

  Fly   262 KYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQH 326
                                                  |:|.|..| |||
pombe   163 --------------------------------------RVSEIILA-TNP--------------- 173

  Fly   327 STESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQR 391

pombe   174 ----------------------------------------------------------------- 173

  Fly   392 MRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGE 456
                      .||:.|.|.||:||||||:||..::..:..|.|:|..||:|:|||.||.:.:..|
pombe   174 ----------LLESFGCAKTLRNNNSSRHGKYLEMIFNSGGVPVGAKITNYLLEKNRIVNQVRNE 228

  Fly   457 RNFHIFYQLLLGADLQLLKSLKLYRNV------EKYELLRNTTAME-------EDRMNFHYTKRS 508
            ||||||||....|.       :.||:.      |.|..   |:|.:       .|..:|..|..:
pombe   229 RNFHIFYQFTKSAP-------QKYRDTYGIQGPENYVY---TSACQCLSVDGISDEKDFQGTMNA 283

  Fly   509 LDVLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILIN 573
            :.|:|::..|.:.|||:::::|.|||..|        .||....:|...:...:.|.....:.:.
pombe   284 MKVIGITEPEQDEIFRMLSIILWLGNIQF--------QEGQDGGSVISDKSITEFLGYLIGVPVA 340

  Fly   574 CLTRANSTNSAQEDVGCE--------MDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQR- 629
            .:.||.:....|...|..        ::..||...|:.|...:|:.||.|:|.::|::|.::..
pombe   341 AIERALTIRIMQTQHGARRGSVYEVPLNPTQALAVRDALSMAIYNCLFDWIVERVNKALVTSDNS 405

  Fly   630 -EKNLALLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNE 693
             ..::.:||.||||..::|||||..|||..||:.|.|:...|::|||.|:||.:.|:.|.||:|:
pombe   406 VSNSIGILDIYGFEIFENNSFEQLCINYVNEKLQQIFIELTLKTEQEEYVREQIAWTPIKYFNNK 470

  Fly   694 SICELID-KPSYGILSLINE----PHLNS--NDALLLRVQQCCAGHPNFMTTGSNSMCFQIRHYA 751
            .:|:||: |...|:.:.:|:    .|.:|  .|:...:.....:.:|:|....:.   |.::|||
pombe   471 VVCDLIESKRPPGLFAAMNDAIATAHADSAAADSAFAQRLNFLSSNPHFEQRQNQ---FIVKHYA 532

  Fly   752 SVVNYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFP---EGNPRRQVTKKPSTLSSNIRTQL 813
            ..|.|||....:||.|.|...|....:.|....::|:||   |.|.||    :|.|....|:|..
pombe   533 GDVTYSITGMTDKNKDQLATDILNLIHSSNNEFMKSIFPVAEESNSRR----RPPTAGDRIKTSA 593

  Fly   814 QTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFH 878
            ..|:..:...:..|:..||||:.|.|:.:|..:|.||::|:.|...:.:.|.|..|......|..
pombe   594 NDLVETLMKCQPSYIRTIKPNQTKSPNDYDQQMVLHQIKYLGLQENIRIRRAGFAYRQAFDTFAQ 658

  Fly   879 RYKLLN-------SLTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFR 936
            |:.:|:       ..||.    |........|:::..:||:|:.:||..||:::|.|::.||..|
pombe   659 RFAVLSGKTSYAGEYTWQ----GDDKSACEQILKDTNIPSSEYQMGTSKVFIKNPETLFALEDMR 719

  Fly   937 RLRISELAVLIQTMFRMYHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVARE 1001
            ......:|..||..:|.| .|:|.:.....|       :.|...:..:         .|.||..|
pombe   720 DKFWDTMATRIQRAWRSY-VRRRSEAAACIQ-------KLWNRNKVNM---------ELERVRNE 767

  Fly  1002 EYRSLKYKRQVRWAIDIIGRYYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLR 1066
            ..:.|:.|:|.|       ||
pombe   768 GTKLLQGKKQRR-------RY-------------------------------------------- 781

  Fly  1067 SIYHRWKCYIYRNSFDQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRL-RHNQQWKKI 1130
                                          .|...||          |.|||:.. :.|......
pombe   782 ------------------------------SILGSRK----------FYGDYLSASKPNGTLWNT 806

  Fly  1131 CAETNDQYVVFA----DIINKIARSSGKFVPILLVLSTSSLLL-----LDQR-TLQIKYRVPASE 1185
            |..:.:.:|:|:    .:::|:.|:| |..|..|||:..:|.|     :||: |.|::.:...|.
pombe   807 CGLSQNDHVIFSMRCEVLVHKLGRTS-KPSPRQLVLTKKNLYLVITKIVDQKLTQQVEKKFAVSS 870

  Fly  1186 IYRMSLSPYLDDIAVFHVKASEFGRKKGDFVFQTGHVIEIVTKMFLVIQN 1235
            |..:.|:...||......|:|:    .||...:.....|.:|.:..:.:|
pombe   871 IDSVGLTNLQDDWVAIRNKSSQ----NGDMFLRCFFKTEFITTLKRINRN 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	34/98 (35%)
		Motor_domain	403..924	CDD:277568	171/560 (31%)
		Myosin_TH1	1092..1267	CDD:283635	37/155 (24%)
myo1	NP_595402.1	MYSc	38..720	CDD:214580	224/973 (23%)
		MYSc_Myo1	54..707	CDD:276829	216/944 (23%)
		Myosin_TH1	765..944	CDD:283635	44/248 (18%)
		SH3_Myosin-I_fungi	1111..1162	CDD:212792
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810