Protein Alignment Myo95E and myo7aa

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_073784889.1
• Gene: myo7aa / 252846
• ZFINID: ZDB-GENE-020709-1
• Length: 2232
• Species: Danio rerio
• Alignment Length: 1231
• Identity: 283/1231 - (22%)
• Similarity: 452/1231 - (36%)
• Gaps: 414/1231 - (33%)

  Fly     6 GTWDSVLLENLSEDSFINNIHQRYKRDHIY------TYIGTSVVALNPYHHISEHSLDNVRNYGD 64
            |..|.:.|.:|:|...:.|:..||:...||      ||.|:.:||:|||..:..::.|.:|.|.:
Zfish    95 GVEDMIRLGDLNEAGILRNLLIRYREHLIYTNCGGRTYTGSILVAVNPYQLLPIYTADQIRLYTN 159

  Fly    65 KGIFQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPN 129
            |.|.::||||:.:.:..|.:::..::|||.:::|||||||||:.|:|:.||
Zfish   160 KKIGEMPPHIFAIADNCYFNMQRNNKDQCCIISGESGAGKTESTKLILQFL-------------- 210

  Fly   130 VLRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAE 194
                                                                             
Zfish   211 ----------------------------------------------------------------- 210

  Fly   195 SIERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKG 259
                                                                        ||..|
Zfish   211 ------------------------------------------------------------AAISG 215

  Fly   260 SPKYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMR 324
                                                                             
Zfish   216 ----------------------------------------------------------------- 215

  Fly   325 QHSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPT 389
            |||...|...|
Zfish   216 QHSWIEQQVLE------------------------------------------------------ 226

  Fly   390 QRMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPII 454
                     |:..|||.|||.|::|:||||:||..||..:.:|...|..|..|:|||:|:.....
Zfish   227 ---------ANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQAR 282

  Fly   455 GERNFHIFYQLLLGADLQLLKSLKLYRNVE-KYELLRNTTAME--EDRMNFHYTKRSLDVLGLSC 516
            .|||:||||.:|.|......|.|.|.:..: .|..:.|.|..:  :|:..:...:.::.||..:.
Zfish   283 DERNYHIFYCMLKGMTPDQKKQLGLSKATDYTYLTIGNCTVCDGRDDQKEYSNIRSAMKVLMFTD 347

  Fly   517 EESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANST 581
            :|:..|.:::|.:|.:||..:...| .|..:.|:|.....:...|.||.::.:.|:|||| :.:.
Zfish   348 KENWEISKLLAAILHMGNLRYEART-YDNLDACEVVRCSALTTAAVLLEVDLKDLMNCLT-SRTI 410

  Fly   582 NSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINES--------LKSTQREKNLALLDF 638
            .:..|.|...:...||...|:...:.:|.|||.|:|.|||.:        ||:.:|  ::.|||.
Zfish   411 ITRGETVSTPLSIEQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSLELKAVRR--SIGLLDI 473

  Fly   639 YGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPS 703
            :|||....|||||..||::.|.:.|.||.||.:.|||.|..|.:.|..|::.||:...::|....
Zfish   474 FGFENFMVNSFEQLCINFANENLQQFFVRHVFKLEQEEYNLENINWQHIEFTDNQDALDMIAIKP 538

  Fly   704 YGILSLINEP-------------HLNSNDALLLRVQQCCAGHPNFM-TTGSNSMCFQIRHYASVV 754
            ..|:|||:|.             .|||...|          :.|:: ...:....|.|:|:|.||
Zfish   539 MNIISLIDEESKFPKGTDTTMLNKLNSQHKL----------NTNYIPPKNTYETQFGIQHFAGVV 593

  Fly   755 NYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLF-----------------PEGNPRR--QVTK 800
            .|....|||||.|.|...|....:.||...::.:|                 ..|:..:  :..|
Zfish   594 YYETRGFLEKNRDTLHGDIIQLVHSSKNKFIKQIFQADVAMFLCGYWSDSLGKAGSLHKGAETRK 658

  Fly   801 KPSTLSSNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRT 865
            :..||||..:..|:.|:..:...:..:|.||||||.|:|..||..|...|:||..:|..:.:.|.
Zfish   659 RSPTLSSQFKRSLELLMRTLSVCQPFFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMETIRIRRA 723

  Fly   866 GHCYHLLHVKFFHRYKLLNSLTWPHF-----HGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRS 925
            |:......|:|..||::|.....|.:     .|..|....|::.|:     .::.:|...:|::.
Zfish   724 GYPIRYTFVEFVDRYRVLMPGVKPAYKQEDLRGTCQRIAEAVLGRD-----DDWQMGKTKIFLKD 783

  Fly   926 PRTVYELEQFRRLRISELAVLIQTMFRMYHARKRFQRMRHSQMIISSAWRTWRECR--FGIPFTG 988
            ...:. ||..|...|::..:|||.:.|.:..|..|.:|:.|.|:|...||.: .||  :|....|
Zfish   784 HHDML-LEIERDKAITDKVILIQKVVRGFKDRSNFLKMKKSAMLIQKTWRGY-YCRKNYGAMRGG 846

  Fly   989 RRHLWSLYRVAREEYRSLKYKRQ-------------VR-------WAIDIIGRYYRQWKIRQFLL 1033
            ...|.:||| :|:.|::....||             ||       ||:..|..|.|....|:..
Zfish   847 FSRLQALYR-SRKLYQTYHVARQRIMLFQGRCRGFLVRRAFRHRLWAVITIQAYTRGMIARRLY- 909

  Fly  1034 TIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIY-HRWKCYIYRNSFDQTARNRM---REKVT 1094
                                         :.|:..| .|.:....|.:.:|..||:|   :.|..
Zfish   910 -----------------------------KRLKGEYRRRLEAEKLRLAEEQKLRNQMSARKAKEE 945

  Fly  1095 ASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAETNDQY-------VVFADIINKI 1148
            |..:.::|.|...|.       |..|.:..:|..:...|..||.       |..:|:::|:
Zfish   946 AEKMHQERLAQLARE-------DAEREKKERQEARRKMEMLDQMEKARQEPVNDSDMVDKM 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	44/122 (36%)
		Motor_domain	<403..937	CDD:473979	174/582 (30%)
		Myosin_TH1	1092..1288	CDD:461801	14/64 (22%)
myo7aa	XP_073784889.1	None