Protein Alignment Myo95E and Myo5a

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001423326.1
• Gene: Myo5a / 25017
• RGDID: 3143
• Length: 1877
• Species: Rattus norvegicus
• Alignment Length: 1091
• Identity: 239/1091 - (21%)
• Similarity: 390/1091 - (35%)
• Gaps: 370/1091 - (33%)

  Fly     5 IGTWDSVLLENLSEDSFINNIHQRY-KRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIF 68
            :|..|...|..|.|.:.::|:..|: ....||||.|..:||:|||..:..:..|.:..|..:.:.
  Rat    69 VGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMG 133

  Fly    69 QLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRK 133
            .:.|||:.:...||:.:.....:|.::::||||||||
  Rat   134 DMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKT---------------------------- 170

  Fly   134 QSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIER 198
                                                                             
  Rat   171 ----------------------------------------------------------------- 170

  Fly   199 QSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKY 263
                                                            |||            ||
  Rat   171 ------------------------------------------------VSA------------KY 175

  Fly   264 AVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHST 328
            |                                                          ||..:|
  Rat   176 A----------------------------------------------------------MRYFAT 182

  Fly   329 ESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMR 393
            .|            ||..     :|:...|||...|
  Rat   183 VS------------GSAS-----EANVEEKVLASNP----------------------------- 201

  Fly   394 ECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERN 458
                    .:|::|||.|.:|:||||:||..:|..|.:...:|.::..|:|||:|:......|||
  Rat   202 --------IMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERN 258

  Fly   459 FHIFYQLLLGADLQLLKSLKLYRNVEKYELLR--NTTAME--EDRMNFHYTKRSLDVLGLSCEES 519
            :||||||...|.|...|.|:| .|.:.:...:  .:..:|  :|.....:|:::..:||:|....
  Rat   259 YHIFYQLCASAKLPEFKMLRL-GNADSFHYTKQGGSPMIEGVDDAKEMAHTRQACTLLGISESYQ 322

  Fly   520 NSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYE-VQETAQLLNMEAQILINCLTRANSTNS 583
            ..|||::|.:|.|||..|..    ..::.|.:...:| :.....|:.::.:.:.:.|.. ....:
  Rat   323 MGIFRILAGILHLGNVGFAS----RDSDSCTIPPKHEPLIIFCDLMGVDYEEMCHWLCH-RKLAT 382

  Fly   584 AQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQREKN-LALLDFYGFEALDHN 647
            |.|.....:...||...|:.|.:.:|::||.|:|..:|::|.|..::.: :.:||.||||..:.|
  Rat   383 ATETYIKPISKLQATNARDALAKHIYAKLFNWIVGHVNQALHSAVKQHSFIGVLDIYGFETFEIN 447

  Fly   648 SFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGILSLINE 712
            |||||.|||:.||:.|.|..||.:.|||.|::|.:.|:.||::||:....||:. ..|||.|::|
  Rat   448 SFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIES-KLGILDLLDE 511

  Fly   713 ------------------PHLNSNDALLLRVQQCCAGHPNFMTTGSNSMCFQIRHYASVVNYSIH 759
                              .|||.           ||   .|.....::..|.|:|:|..|.|...
  Rat   512 ECKMPKGTDDTWAQKLYNTHLNK-----------CA---LFEKPRMSNKAFIIKHFADKVEYQCE 562

  Fly   760 RFLEKNSDMLPKYISAAFYQSKLSLVQSLFPE---------------------------GNPRRQ 797
            .|||||.|.:.:........||..::..||.:                           |.|.:.
  Rat   563 GFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRVPVKPTKGRPGQT 627

  Fly   798 VTKKPSTLSSNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHL 862
            ..:...|:....|..|..|:..:.....|||.|||||:.|.|..||......|:|...::..:.:
  Rat   628 AKEHKKTVGLQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRI 692

  Fly   863 CRTGHCYHLLHVKFFHRYKLL----NSLTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFV 923
            ...|......:.:||.||::|    :.|       |.:.:....::..|.|...::..|...:|.
  Rat   693 SAAGFPSRWTYQEFFSRYRVLMKQKDVL-------GDRKQTCQNVLEKLILDKDKYQFGKTKIFF 750

  Fly   924 RSPRTVYELEQFRRLRISELAVLIQTMFRMYHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTG 988
            |:.:..| ||:.|..::....:.||...|.:..|||:..|:.:.:.:....|.: :.|....|..
  Rat   751 RAGQVAY-LEKLRADKLRAACIRIQKTIRGWLLRKRYLCMQRAAITVQRYVRGY-QARCYAKFLR 813

  Fly   989 R-------RHLWSLYRVAREEYRSLKYKRQVRWAIDIIGRYYRQWKIRQFL 1032
            |       :..|.:|.|.|      |||  :|.|..|:.:.|    :|.:|
  Rat   814 RTKAATTIQKYWRMYVVRR------KYK--IRRAATIVLQSY----LRGYL 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	33/118 (28%)
		Motor_domain	<403..937	CDD:473979	164/588 (28%)
		Myosin_TH1	1092..1288	CDD:461801
Myo5a	NP_001423326.1	COG5022	7..1445	CDD:227355	239/1091 (22%)
		MYSc_Myo5	83..751	CDD:276831	205/960 (21%)
		Myo5a_CBD	1503..1877	CDD:271262