DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo95E and Myo1h

DIOPT Version :9

Sequence 1:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001158045.1	Gene:	Myo1h / 231646	MGIID:	1914674	Length:	1022	Species:	Mus musculus

Alignment Length:	1301	Identity:	328/1301 - (25%)
Similarity:	535/1301 - (41%)	Gaps:	357/1301 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EIGTWDSVLLE-NLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGI 67
            ::|..|.|||: ..||.:|:.|:.:|::.:.|||||||.:|::|||..:..::...:..|.....
Mouse    10 KVGVQDFVLLDAYTSESAFLENLRKRFRENLIYTYIGTLLVSVNPYQELGIYTASQMELYQGVNF 74

  Fly    68 FQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLR 132
            |:||||:|.:.:.||:.:..:..:..:|::|||||||||..|.|:.:
Mouse    75 FELPPHVYAIADNAYRMMCSELNNHFILISGESGAGKTEASKKILQY------------------ 121

  Fly   133 KQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIE 197

Mouse   122 ----------------------------------------------------------------- 121

  Fly   198 RQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPK 262

Mouse   122 ----------------------------------------------------------------- 121

  Fly   263 YAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHS 327
            :||             .|...:||:                ||
Mouse   122 FAV-------------TCPMTESLQ----------------IA---------------------- 135

  Fly   328 TESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRM 392
                    |||                    :|..:|
Mouse   136 --------RDR--------------------LLLSIP---------------------------- 144

  Fly   393 RECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGER 457
                     .|||.|||.||:|:||||:||..||:.||:|.|:|.||..|::||:|:.....|||
Mouse   145 ---------VLEAFGNAKTLRNDNSSRFGKYMDIQFDFQGVPVGGHIISYLIEKSRVVYQNHGER 200

  Fly   458 NFHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAMEE----DRMNFHYTKRSLDVLGLSCEE 518
            |||||||||.|...:.|.||.|.|:.:.|:.|.......|    |:.::.....:..|:|.:..:
Mouse   201 NFHIFYQLLAGGGSERLASLGLERDPQLYKYLSQGHCARESPISDKNDWETVCGAFSVIGFTEAD 265

  Fly   519 SNSIFRVIAVVLKLGNFIFVPITNIDGTEGC-QVSNVYEVQETAQLLNMEAQILINCLTRANSTN 582
            ..::|.:||.||.|||..|.     ...:|| .|.:.:|::..|:||.:...:|:..||. ....
Mouse   266 LENLFGIIASVLHLGNVCFK-----GDKQGCASVPDTHEIKWIAKLLGVCPAVLLEALTH-RKIE 324

  Fly   583 SAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESL--KSTQREKNLALLDFYGFEALD 645
            :..|:|.|.:....:...|:.:.:.:|.|.||||||:||.||  |...::..:.|||.||||..|
Mouse   325 AKTEEVICPLTVELSVYARDAMAKAVYGRTFTWLVNRINSSLVNKDFTQKTVIGLLDIYGFEVFD 389

  Fly   646 HNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGILSLI 710
            .|.||||.|||..||:.|..:...|::||..|..||:||..:.||:|:.||:|:::...||:|::
Mouse   390 KNGFEQFCINYCNEKLQQLLIERTLKAEQAEYESEGIEWETVQYFNNKIICDLVEERHRGIISIL 454

  Fly   711 NEPHLNSNDA----LLLRVQQCCAGHPNFMT---TGSNS------MCFQIRHYASVVNYSIHRFL 762
            :|..:....|    .|.::::....|.:|.|   .|...      :.|.:.|||..|.|....||
Mouse   455 DEECIRPGPATDLSFLEKLEEKVGKHAHFQTRKLAGPKGRKRIGWLEFCLLHYAGEVTYCTKGFL 519

  Fly   763 EKNSDMLPKYISAAFYQSKLSLVQSLF--PEGNPRRQVTKKPSTLSSNIRTQLQTLLAIVKHRRS 825
            |||:|:|.:::......||.|:::..|  .|...||    :|.|:.:..:..|.:||.|:..:..
Mouse   520 EKNNDLLYRHLKEVLCSSKNSILRECFLVAELENRR----RPPTVGTQFKNSLSSLLEILISKEP 580

  Fly   826 HYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWPH 890
            .|:.||||||.|:|.:||..|:.||::|:.||..:.:.|.|..|...:..|..|||.|...||||
Mouse   581 SYIRCIKPNERKEPSKFDDFLISHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWPH 645

  Fly   891 FHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYH 955
            :| |...||:..:|:.:.....::.:|...:|:|.|||::..|........:|...||..::...
Mouse   646 WH-GPPGEGVERLIKYIGYQPQDYKLGKTKIFIRFPRTLFATEDAFEFSKHQLVSRIQATYKGCL 709

  Fly   956 ARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAIDIIG 1020
            .|:.:.:.|.:...:.:.||       |:             :||:|     .||: |||:.||.
Mouse   710 GRREYMKKRQAATKLEAHWR-------GV-------------LARKE-----IKRR-RWAVQIIR 748

  Fly  1021 RYYRQWKIR-----------------QFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSI 1068
            |:.:.:..|                 .::|.:...:|.|.   |...|...|..|.:||..||.:
Mouse   749 RFVKGFINRDKPLCPDNEEFVVLVRKNYILNLRYHVPKNV---LDKSWLRPPGILENASNLLRRM 810

  Fly  1069 YHRWKCYIYRNSFDQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAE 1133
            ..|.....|........:..|::||..|.||:.:|..|..|:...|.|.  ||..:....|:...
Mouse   811 CTRNLVRKYCRGISAERKAMMQQKVVTSEIFRGKKEGYAESLNQLFAGS--RLDESNINPKVLQL 873

  Fly  1134 TNDQYVVFADIINKIARSSGKFVPILLVLSTSSLLLLDQRTLQIKYRVPASEIYRMSLSPYLDDI 1198
            ...:.:.:...:.|..|...|.....|:|:..|..|::  ..::|.::..:.:..:|.|...|.|
Mouse   874 LGSEKIQYGVPVIKYDRKGFKARQRQLLLTQRSAYLVE--LSKVKQKIEYAAVRGVSTSSLSDGI 936

  Fly  1199 AVFHVKASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGKPPEIHI---STEFEANFGQQ-TVI 1259
            .|.|:..:: .::|||.:.|..|:.|:.||:.::|:    |...:.:   |.:|..:.|:: |::
Mouse   937 LVIHISPAD-KQQKGDVILQCEHIFEVATKLAMLIR----KEHTVRVVQGSLQFYVSPGREGTIV 996

  Fly  1260 F 1260
            |
Mouse   997 F 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	35/98 (36%)
		Motor_domain	403..924	CDD:277568	193/542 (36%)
		Myosin_TH1	1092..1267	CDD:283635	42/173 (24%)
Myo1h	NP_001158045.1	MYSc	8..689	CDD:214580	252/953 (26%)
		MYSc_Myo1	26..678	CDD:276829	240/926 (26%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	568..590		9/21 (43%)
		Myosin_TH1	834..1001	CDD:283635	42/173 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820