Protein Alignment Myo95E and MYH15

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_011510861.1
• Gene: MYH15 / 22989
• HGNCID: 31073
• Length: 1946
• Species: Homo sapiens
• Alignment Length: 1171
• Identity: 258/1171 - (22%)
• Similarity: 411/1171 - (35%)
• Gaps: 409/1171 - (34%)

  Fly     9 DSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQLPPH 73
            |..:|.:|:|.|.::.:.:||.:..||||.|...|.:|||..:..:..:.:..|..|...:.|||
Human   107 DMAMLTHLNEASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPH 171

  Fly    74 IYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSSTS 138
            |:.:.|.|:|.:....|:|.:|.|||||||||...|.|:.:..
Human   172 IFAVANNAFQDMLHNRENQSILFTGESGAGKTVNSKHIIQYFA---------------------- 214

  Fly   139 SASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSRRH 203
                                                                |.|..||  ||:
Human   215 ----------------------------------------------------TIAAMIE--SRK- 224

  Fly   204 MREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVPTV 268
                                                                             
Human   225 ----------------------------------------------------------------- 224

  Fly   269 YGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQPE 333
                                                                   :|.:.|.|
Human   225 -------------------------------------------------------KQGALEDQ-- 232

  Fly   334 RERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECVTC 398
                                                                          :..
Human   233 --------------------------------------------------------------IMQ 235

  Fly   399 ADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHIFY 463
            |:..|||.|||.||:|:||||:||...:....:|....|.|..|:|||:|:.....||||:||||
Human   236 ANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFY 300

  Fly   464 QLLLGADLQLLKSLKLYRNVEKYELLRNTTAMEEDRMNFHY-------------------TKRSL 509
            |:|.|             ..|.::||    .:..:..:||:                   |::::
Human   301 QILSG-------------QKELHDLL----LVSANPSDFHFCSCGAVTVESLDDAEELLATEQAM 348

  Fly   510 DVLGLSCEESNSIFRVIAVVLKLGNFIF-----VPITNIDGTEGCQVSNVYEVQETAQLLNMEAQ 569
            |:||...:|....:::...::..||..|     ......||||        ...:.|.|:.:.:.
Human   349 DILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTE--------NADKAAFLMGINSS 405

  Fly   570 ILINCL------------TRANSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINE 622
            .|:.||            ||..:.    |.|.|.:.|         |.:::|.|:|.|||.:||.
Human   406 ELVKCLIHPRIKVGNEYVTRGQTI----EQVTCAVGA---------LSKSMYERMFKWLVARINR 457

  Fly   623 SLKS-TQREKNLALLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSR 686
            :|.: ..|:..:.:||..|||.|::||.||..||::.||:.|.|.:|:...|||.|.:|.:||..
Human   458 ALDAKLSRQFFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVS 522

  Fly   687 IDY-FDNESICELIDKPSYGILSLINEP------------------HLNSNDALLLRVQQCCAGH 732
            |.: .|.::..:||:|| .||||::.|.                  |...:    :.:|:.....
Human   523 IGFGLDLQACIDLIEKP-MGILSILEEECMFPKATDLTFKTKLFDNHFGKS----VHLQKPKPDK 582

  Fly   733 PNFMTTGSNSMCFQIRHYASVVNYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLF-------- 789
            ..|      ...|::.|||.||.|:|..:||||.|:|.:.:.|.|.:|...|:.|||
Human   583 KKF------EAHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDS 641

  Fly   790 --PEGNPRRQVTKKPSTLSSNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVR 852
              |.|..:|:......|::|..:..|..|:..:|....|:|.||.||..|.|...|..||..|:|
Human   642 AIPFGEKKRKKGASFQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLR 706

  Fly   853 YMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWPHFHGGSQVEGIALIIRNLPLPSAEFTIG 917
            ...::....:||.|....|.:..|..||.:||..|:|.....|..:....::.:|.:...::..|
Human   707 CNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSRKAAEELLGSLEIDHTQYRFG 771

  Fly   918 TKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYHARKRFQR-MRHSQMIISSAWR------ 975
            ...||.:: ..:.:||..|..|:|::..|.|...:....|.:||: :.....:|...|.
Human   772 ITKVFFKA-GFLGQLEAIRDERLSKVFTLFQARAQGKLMRIKFQKILEERDALILIQWNIRAFMA 835

  Fly   976 ----TWRECRFGI-PFTGRRHLWSLYRVAREEYRSLKYK-RQVRWAIDIIGRYYRQWKIRQFLLT 1034
                .|....|.| |......:       .||...||.: .|::.|::.......:.|.:|..||
Human   836 VKNWPWMRLFFKIKPLVKSSEV-------GEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLT 893

  Fly  1035 -------IPLRLPPNTLSPL--STEWPVAPAFLADASRHLRSIYHRWKCYIYRNSFDQTARNRMR 1090
                   :.|:....||:.:  ..||.:......:|  .::.:..|.:.....|| :.|||.|..
Human   894 QEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEA--RVKELSERVEEEEEINS-ELTARGRKL 955

  Fly  1091 E 1091
            |
Human   956 E 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	39/113 (35%)
		Motor_domain	<403..937	CDD:473979	171/599 (29%)
		Myosin_TH1	1092..1288	CDD:461801	258/1171 (22%)
MYH15	XP_011510861.1	COG5022	53..1460	CDD:227355	258/1171 (22%)
		MYSc_Myh15_mammals	117..778	CDD:276892	214/970 (22%)
		SMC_prok_B	1093..1932	CDD:274008