Protein Alignment Myo95E and Myo6

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001395181.1
• Gene: Myo6 / 17920
• MGIID: 104785
• Length: 1294
• Species: Mus musculus
• Alignment Length: 1089
• Identity: 229/1089 - (21%)
• Similarity: 384/1089 - (35%)
• Gaps: 393/1089 - (36%)

  Fly     9 DSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISE-HSLDNVRNYGDKGIFQLPP 72
            |:..|..|:|.:.::|:..||.:|.||||:...::|:|||..|.: :|.|.:::|..|.:..:||
Mouse    61 DNCSLMYLNEATLLHNVKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSDTIKSYQGKSLGTMPP 125

  Fly    73 HIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSST 137
            |::.:.:.|::.:|.....|.::::|||||||||..|.::.:||.
Mouse   126 HVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTE-------------------- 170

  Fly   138 SSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSRR 202
                                                        |.|..|
Mouse   171 --------------------------------------------SYGTGQ--------------- 176

  Fly   203 HMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVPT 267
                   |.|
Mouse   177 -------DID------------------------------------------------------- 179

  Fly   268 VYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQP 332
                                                                             
Mouse   180 ----------------------------------------------------------------- 179

  Fly   333 ERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECVT 397
                ||                                                         :.
Mouse   180 ----DR---------------------------------------------------------IV 183

  Fly   398 CADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHIF 462
            .|:..|||.|||.|::||||||:||..:|..:.|...:|..::||:|||:||......|||:|||
Mouse   184 EANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIF 248

  Fly   463 YQLLLGADLQLLKSLKL----------------YRNVE-KYELLRNTTAME------------ED 498
            |:|..||...:.:.|.|                :.|.| ..::|:|..:.|            :|
Mouse   249 YRLCAGASEDIREKLHLSSPDNFRYLNRGCTRFFANKETDKQILQNRKSPEYVKAGSLKDPLLDD 313

  Fly   499 RMNFHYTKRSLDVLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSN--VYEVQETA 561
            ..:|.....::..:||..||...:|||:|.||.|||..|....:..|  ||.:.|  ...::..|
Mouse   314 HGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG--GCNLKNKSAPSLEYCA 376

  Fly   562 QLLNMEAQIL-INCLTRANSTNSAQED---VGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINE 622
            :||.::...| ::..||...|.:....   :...:...||...|:.|.:|:||.||..:||::|:
Mouse   377 ELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQ 441

  Fly   623 SLKSTQREKNLALLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRI 687
            ..........:.:||..|||..:|||||||.|||..||:.|.|...:|:.|||||.:|||..:.:
Mouse   442 CFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEV 506

  Fly   688 DYFDNESICELIDKPSYGILSLINEP---------------HLNSNDALLLRV--QQCCAGHPNF 735
            .|.||:...:||:....|||.:::|.               |....|...|.:  :...|.|.|.
Mouse   507 HYVDNQDCIDLIEVKLVGILDILDEENRLPQPSDQHFTSVVHQKHKDHFRLTIPRKSKLAVHRNL 571

  Fly   736 MTTGSNSMCFQIRHYASVVNYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTK 800
                .:...|.|||:|..|.|...:|:|||:|.|...:.:...:|:...:::||.......:.||
Mouse   572 ----RDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRALFESSTNNNKDTK 632

  Fly   801 KPS------TLSSNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPL 859
            :.:      ::.:..:|||..||..::...:.::.|||||.....|.|:.|.:..|::...::.:
Mouse   633 QKAGKLSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSV 697

  Fly   860 VHLCRTGHCYHLLHVKFFHRYKLLNSLTWPHFHGGSQVEGIA---------LIIRNLPLPSAEFT 915
            :.|.:.|........:.::.||..            ..|.:|         .:.:.|.|...::.
Mouse   698 LDLMQGGFPSRASFHELYNMYKKY------------MPEKLARLDPRLFCKALFKALGLNEVDYK 750

  Fly   916 IGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYHARKRFQRMRHSQMIISSAWRTWREC 980
            .|...||.| |....|.:|..:.....||.|::               |.:..::.|.|:..:.|
Mouse   751 FGLTKVFFR-PGKFAEFDQIMKSDPDHLAELVK---------------RVNLWLVCSRWKKVQWC 799

  Fly   981 RFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAIDI---IGRYYRQW 1026
            ...:                     :|.|.::::..:.   :.:..|.|
Mouse   800 SLSV---------------------IKLKNKIKYRAEACIKMQKTIRMW 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	39/114 (34%)
		Motor_domain	<403..937	CDD:473979	171/600 (29%)
		Myosin_TH1	1092..1288	CDD:461801
Myo6	NP_001395181.1	MYSc_Myo6	71..759	CDD:276833	210/972 (22%)
		CBD_MYO6-like	770..917	CDD:409646	11/94 (12%)
		MYO6_MIU_linker	999..1068	CDD:412090
		MyUb_Myo6	1082..1122	CDD:439319
		Myosin-VI_CBD	1177..1267	CDD:465157