Protein Alignment Myo95E and Myo1c

DIOPT Version :9

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001357540.1
• Gene: Myo1c / 17913
• MGIID: 106612
• Length: 1063
• Species: Mus musculus
• Alignment Length: 1335
• Identity: 353/1335 - (26%)
• Similarity: 553/1335 - (41%)
• Gaps: 376/1335 - (28%)

  Fly     5 IGTWDSVLLENL-SEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIF 68
            :|..|.|||||. ||.:||.|:.:|::.:.||||||..:|::|||..:..:|..::..|.....:
Mouse    46 VGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFY 110

  Fly    69 QLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRK 133
            ::|||::.:.:..|::|:.:..||.|:::|||||||||..|.::.|.
Mouse   111 EVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFY------------------ 157

  Fly   134 QSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIER 198
                                                                             
Mouse   158 ----------------------------------------------------------------- 157

  Fly   199 QSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKY 263
                                                                             
Mouse   158 ----------------------------------------------------------------- 157

  Fly   264 AVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHST 328
                                                       |.|.|| |.||..   :|....
Mouse   158 -------------------------------------------AETCPA-PERGGA---VRDRLL 175

  Fly   329 ESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMR 393
            :|.|
Mouse   176 QSNP------------------------------------------------------------- 179

  Fly   394 ECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERN 458
                    .|||.|||.||:|:||||:||..|::.||||.|:|.||..|:|||:|:.....||||
Mouse   180 --------VLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERN 236

  Fly   459 FHIFYQLLLGADLQLLKSLKLYRNVEKY-ELLRNTTAME---EDRMNFHYTKRSLDVLGLSCEES 519
            ||:|||||.|.:.:.|:.|.|.||.:.| .|::...|..   .|:.::...:::|.|:..:.:|.
Mouse   237 FHVFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVMRKALSVIDFTEDEV 301

  Fly   520 NSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTNSA 584
            ..:..::|.||.|||..|.    .|.....||:...:::...:||.:|...|...||........
Mouse   302 EDLLSIVASVLHLGNIHFA----ADEDSNAQVTTENQLKYLTRLLGVEGTTLREALTHRKIIAKG 362

  Fly   585 QEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQREKN-------LALLDFYGFE 642
            :|.:. .::..|||..|:.|.:.:|||.|||||.|||.||.|...|..       |.|||.||||
Mouse   363 EELLS-PLNLEQAAYARDALAKAVYSRTFTWLVRKINRSLASKDAESPSWRSTTVLGLLDIYGFE 426

  Fly   643 ALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGIL 707
            ...|||||||.|||..||:.|.|:...|:||||.|..||:.|..:.||:|:.||:|:::...||:
Mouse   427 VFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGII 491

  Fly   708 SLINEPHLNSNDA----LLLRVQQCCAGHPNFMT-------------TGSNSMCFQIRHYASVVN 755
            |:::|..|...:|    .|.:::.....||:|:|             .|.    |::.|||..|.
Mouse   492 SILDEECLRPGEATDLTFLEKLEDTVKPHPHFLTHKLADQKTRKSLDRGE----FRLLHYAGEVT 552

  Fly   756 YSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRTQLQTLLAIV 820
            ||:..||:||:|:|.:.:......|...::...|.:.....:  |:|.|:::..:..|..|:.|:
Mouse   553 YSVTGFLDKNNDLLFRNLKETMCSSMNPIMAQCFDKSELSDK--KRPETVATQFKMSLLQLVEIL 615

  Fly   821 KHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNS 885
            :.:...|:.|||||:.|||.:||..|::|||:|:.||..:.:.|.|..|...:..|..|||.|..
Mouse   616 RSKEPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRKYEAFLQRYKSLCP 680

  Fly   886 LTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTM 950
            .|||.:.|..| :|:|:::|:|.....|:.:|...:|:|.|:|::..|....:|...||..||..
Mouse   681 ETWPMWAGRPQ-DGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDSLEVRRQSLATKIQAA 744

  Fly   951 FRMYHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWA 1015
            :|.:|.|::|.|::.|.:.|.|.||         ...|||      :.|:.           :||
Mouse   745 WRGFHWRQKFLRVKRSAICIQSWWR---------GTLGRR------KAAKR-----------KWA 783

  Fly  1016 IDIIGRYYRQWKIR-----------------QFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASR 1063
            ...|.|..|.:.:|                 .|||.:..:||.|.   |.|.||..|..|.:||.
Mouse   784 AQTIRRLIRGFILRHSPRCPENAFFLDHVRASFLLNLRRQLPRNV---LDTSWPTPPPALREASE 845

  Fly  1064 HLRSIYHR---WKCYIYRNSFDQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQ 1125
            .||.:..:   ||   |..|.....:.::::|..||.|||.:|.:|.:||...|:.  .||...:
Mouse   846 LLRELCMKNMVWK---YCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFIS--TRLGTEE 905

  Fly  1126 QWKKICAETNDQYVVFADIINKIARSSGKFVPILLVLSTSSLLLLDQRTLQIKYRVPASEIYRMS 1190
            ...::......:.:.:|..:.|..|...|..|..|:|:.|::::::.  .::|.|:..:.:..:|
Mouse   906 ISPRVLQSLGSEPIQYAVPVVKYDRKGYKPRPRQLLLTPSAVVIVED--AKVKQRIDYANLTGIS 968

  Fly  1191 LSPYLDDIAVFHVKASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGKPPEIHISTEFEANFGQ 1255
            :|...|.:.|.||: .|..::|||.|.|:.||||.:||..|......            ..|..|
Mouse   969 VSSLSDSLFVLHVQ-REDNKQKGDVVLQSDHVIETLTKTALSADRVN------------NININQ 1020

  Fly  1256 QTVIFSFKYG--GMSDLAQGPPKVTRKANRMEIIV 1288
            .::.|:...|  |:.|...|...:..||....:.|
Mouse  1021 GSITFAGGPGRDGIIDFTSGSELLITKAKNGHLAV 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	35/98 (36%)
		Motor_domain	403..924	CDD:277568	198/548 (36%)
		Myosin_TH1	1092..1267	CDD:283635	46/176 (26%)
Myo1c	NP_001357540.1	MYSc_Myo1	62..718	CDD:276829	243/931 (26%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	608..630		8/21 (38%)
		IQ	756..776	CDD:197470	9/34 (26%)
		Myosin_TH1	874..1038	CDD:336273	48/180 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720