Protein Alignment Myo95E and Myo1b

DIOPT Version :9

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_006495827.1
• Gene: Myo1b / 17912
• MGIID: 107752
• Length: 1138
• Species: Mus musculus
• Alignment Length: 1399
• Identity: 400/1399 - (28%)
• Similarity: 647/1399 - (46%)
• Gaps: 383/1399 - (27%)

  Fly     1 MEQEIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDK 65
            ::..||..|.||||.|:|::||:|:.:|:..:.||||||:.|:::|||..:..:|.:.|.:|.::
Mouse    11 LDNMIGVGDMVLLEPLNEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSLPIYSPEKVEDYRNR 75

  Fly    66 GIFQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNV 130
            ..::|.|||:.|::.||:||:||.:|||:|:||||||||||..|::::::..:
Mouse    76 NFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAV------------ 128

  Fly   131 LRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAES 195
                                                                             
Mouse   129 ----------------------------------------------------------------- 128

  Fly   196 IERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGS 260
                                                                             
Mouse   129 ----------------------------------------------------------------- 128

  Fly   261 PKYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQ 325
                          ||                                       :|:..|.:::
Mouse   129 --------------CG---------------------------------------KGAEVNQVKE 140

  Fly   326 HSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQ 390
            ...:|.|
Mouse   141 QLLQSNP---------------------------------------------------------- 147

  Fly   391 RMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIG 455
                       .|||.|||.|::|:||||:||..|||.||||||:|..|::|:|||:|:.....|
Mouse   148 -----------VLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRG 201

  Fly   456 ERNFHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAM---EEDRMNFHYTKRSLDVLGLSCE 517
            |||||:|||||.||..:||..|||.|:..:|..|...:|.   .:|..||...:.::.::|....
Mouse   202 ERNFHVFYQLLSGASEELLYKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFLDH 266

  Fly   518 ESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTN 582
            |:.::..|:|.||||||..|.|.:.::|.:..::.:..|::|..:|.::: |:::.......:..
Mouse   267 EAEAVLEVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTSID-QVVLERAFSFRTVE 330

  Fly   583 SAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQ--REKNLALLDFYGFEALD 645
            :.||.|...::..||...|:.|.:.||||||:||||:||||:|:..  |:|.:.:||.||||..:
Mouse   331 AKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFE 395

  Fly   646 H--NSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGILS 708
            :  ||||||.|||..||:.|.|:...|:.|||.||||.:||:.||||:|..||:||:..:.|||:
Mouse   396 NADNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILA 460

  Fly   709 LINE----PHLNSNDALLLRVQQCCAGHPNFM------------TTGSNSMCFQIRHYASVVNYS 757
            :::|    |...:::..|.::.|.||.|.:|.            ||..:| ||:|:|||..|.|.
Mouse   461 MLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTTLPHS-CFRIQHYAGKVLYQ 524

  Fly   758 IHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRTQLQTLLAIVKH 822
            :..|::||:|:|.:.:|.|.:::..||::||||||||.:...|:|.|..|..:..:.||:..::.
Mouse   525 VEGFVDKNNDLLYRDLSQAMWKAGHSLIKSLFPEGNPAKVNLKRPPTAGSQFKASVATLMRNLQT 589

  Fly   823 RRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLT 887
            :..:|:.|||||:.|..|.|:.:||.||:||:.|:..|.:.|.|:.:...:.....|||:|...|
Mouse   590 KNPNYIRCIKPNDKKAAHIFNESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQT 654

  Fly   888 WPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTM-- 950
            |||:.|.:: .|:.::...|.:|..|.:.|...:|:|:|||:::||..|:.|:.:||.|||.:
Mouse   655 WPHWKGPAR-SGVEVLFNELEIPVEEHSFGRSKIFIRNPRTLFQLEDLRKQRLEDLATLIQKIYR 718

  Fly   951 ---------------------FRMYHARKRFQRMRHSQMIISSAWRTW------------RECR- 981
                                 :|.|..:||:|:::.|.::|.|..|.|            :.|:
Mouse   719 GWKCRTHFLLMKRSQVVIAAWYRRYAQQKRYQQIKSSALVIQSYIRGWKARKILRELKHQKRCKE 783

  Fly   982 -------FGIPFTGRRHL----------------WS--LYRVAREEYRSLKYKRQVRWAIDIIGR 1021
                   :......||.|                |:  |...||.|.:.||.:.:.:.|:.:|..
Mouse   784 AATTIAAYWHGTQARRELRRLKDEARNKHAIAVIWAYWLGSKARRELKRLKEEARRKHAVAVIWA 848

  Fly  1022 YYRQWKIR-------------------------QFLLTIPLRLPPNTLSPLSTEWPVAP-AFLAD 1060
            |:...|:|                         ::||.:..::|  :|||:...||..| .||..
Mouse   849 YWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYLLEMKNKMP--SLSPIDKNWPSRPYLFLDS 911

  Fly  1061 ASRHLRSIYHRWKCYIYRNSFDQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQ 1125
            ..:.|:.|:|.|:|..||:.|....:....||:.||.:|||:||.|..|||.||.|.|:.:..|.
Mouse   912 THKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNP 976

  Fly  1126 QWKKICAETNDQYVVFADIINKIARSSGKFVPILLVLSTSSLLLLDQRTLQIKYRVPASEIYRMS 1190
            ::||: .:..::.::.|:::|||.|::||....:.:|:.::|||.||::.|||..||..::.::|
Mouse   977 KYKKL-KDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTKVS 1040

  Fly  1191 LSPYLDDIAVFHVKASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGKPPEIHISTEFEANFGQ 1255
            :|...|.....|:|.......||||:|.:.|:||:.||::....:.|.:...|.||.||...|.|
Mouse  1041 MSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQ 1105

  Fly  1256 QTVIFSFKYGGMSDLAQGPPKVTRKANR-MEIIV 1288
            ..|...|..|...:  ...|...||.|| :|:.|
Mouse  1106 DKVCVKFIQGNQKN--GSVPTCKRKNNRLLEVAV 1137

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	43/98 (44%)
		Motor_domain	403..924	CDD:277568	213/543 (39%)
		Myosin_TH1	1092..1267	CDD:283635	63/174 (36%)
Myo1b	XP_006495827.1	MYSc_Myo1	29..690	CDD:276829	262/927 (28%)
		IQ	751..773	CDD:197470	5/21 (24%)
		Myosin_TH1	943..1120	CDD:368706	63/179 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5888
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7856
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1574
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.760