DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo95E and nmy-3

DIOPT Version :9

Sequence 1:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_501620.2	Gene:	nmy-3 / 177750	WormBaseID:	WBGene00012437	Length:	1464	Species:	Caenorhabditis elegans

Alignment Length:	1050	Identity:	245/1050 - (23%)
Similarity:	398/1050 - (37%)	Gaps:	334/1050 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LENLSED----------SFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGI 67
            |.|.|||          :.:|.:..||..:.|:|:.|...|.:||:.:|..:| |.|     |.:
Worm    81 LNNYSEDLCTLTQPNAATVLNALKIRYTSNVIHTFCGLFCVVINPWRNIPIYS-DEV-----KQL 139

  Fly    68 FQ----LPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTP 128
            :|    ||||:|.:...|:..:.....:|.:|:||||||||||..|.|::|:.
Worm   140 YQLQNDLPPHVYSVAQNAFHGILKGGRNQSILITGESGAGKTENTKKIIDFIL------------ 192

  Fly   129 NVLRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRA 193
                                                       |.|||
Worm   193 -------------------------------------------SSSVS----------------- 197

  Fly   194 ESIERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAK 258

Worm   198 ----------------------------------------------------------------- 197

  Fly   259 GSPKYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLM 323

Worm   198 ----------------------------------------------------------------- 197

  Fly   324 RQHSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSP 388
                                             :..:||
Worm   198 ---------------------------------NNTIGD-------------------------- 203

  Fly   389 TQRMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPI 453
                  ||..:.|.|||||||.|..|:||||:||...||.|.....:|..|..|:|||:|:....
Worm   204 ------CVVTSGVLLEAMGNARTTHNSNSSRFGKFIRIEFDENSKLIGAKIECYLLEKSRVVFQS 262

  Fly   454 IGERNFHIFYQLLLGADLQLLKS-LKLYRNVEKYELLRNTTAMEEDRMNFHYTKRSLDVLGLSCE 517
            .|:||||||||:|........|| |||.:.|.:|:.|||..:|.:|......|..:...:|||.|
Worm   263 DGDRNFHIFYQMLSNYFDNPHKSFLKLSKKVNEYKYLRNDDSMIDDAETAKMTDEAFTRIGLSEE 327

  Fly   518 ESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTN 582
            |...||::::.||.:|:..|...:.:|.:   .|.::.||...|:||.|::..|::.||:. :..
Worm   328 EKIWIFQILSAVLWIGDIKFGERSGLDVS---FVESMQEVDNIAELLEMKSSKLVDALTQP-TIK 388

  Fly   583 SAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESL-----KSTQR-EKNLALLDFYGF 641
            ...:.:....:..:..::.:.:.:.||.|||.|:|.:.|::.     :||.| .:.:|:||..||
Worm   389 VHDKLIRKNQNLAKTLSSASAMAKILYERLFGWIVKRCNDAFSVDDTESTCRLSRFIAVLDIAGF 453

  Fly   642 EALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDN-ESICELIDKPSYG 705
            |.::.||||||.|||:.||:.|.|...:...||..|:.||::|:::::.:: :...:||:|| .|
Worm   454 EIIEKNSFEQFCINYTNEKLQQFFNHFMFAKEQSDYLEEGIKWTQVNFANHLQPTIDLIEKP-MG 517

  Fly   706 ILSLINEPHLNSNDALLLRVQQCCAGHPN---FMTTGSNSMC-----FQIRHYASVVNYSIHRFL 762
            |||.:.|..:..|.:....:::.|:...|   |..:.....|     |.::|||..|:|:|..:|
Worm   518 ILSFLEEECVVPNGSEKSLLEKLCSNLSNDSSFKKSKQTQKCSTIRHFYVQHYAGEVHYNIDGWL 582

  Fly   763 EKNSDMLPKYISAAFYQSKLSLVQSLFP----EGNPRRQVTKKPSTLSSNIRTQLQTLLAIVKHR 823
            :||.|.:...:.....||...|::.|||    .....|:.|...||:|...:.|||.||..:...
Worm   583 DKNRDNVETSVLDILSQSTHPLLKLLFPPVPVNNLKTRRGTITNSTVSFLYKNQLQCLLDTLNSS 647

  Fly   824 RSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTW 888
            .:|::.|:..|..|.|.:.|..||..|::...::..:.:||.|:...|.|.:|..||.||.. ..
Worm   648 SAHFIRCVVSNYEKLPGKIDAPLVLAQLKCNGVLEGIRICREGYPSRLSHSEFIERYSLLMK-NK 711

  Fly   889 PHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRM 953
            ....|.|:.|...||.::..:....:.:|...:|.: ...:.|||..|...||...:|||...|.
Worm   712 EQSKGASEKEKCTLICQDAQVRKERYAVGKTKLFCK-VGVISELETKRNNYISSFIILIQANIRY 775

  Fly   954 YHARK-RFQRMRHSQMIIS-----------SAW---RTWRECRFGIPFTGRRHLWSLYRVAREEY 1003
            .:.:| ..:|.:..:.:::           |.|   |.:...|..||....:.     |:...|.
Worm   776 LNIQKDLIERRKKLEAVVTIQDNVRQFAELSQWPWYRIYHLTRGLIPRNRDKE-----RIEELEN 835

  Fly  1004 RSLKYKRQVR 1013
            ..||.:.:::
Worm   836 EKLKLEEEIQ 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	37/112 (33%)
		Motor_domain	403..924	CDD:277568	173/540 (32%)
		Myosin_TH1	1092..1267	CDD:283635
nmy-3	NP_501620.2	MYSc_class_II	97..747	CDD:276951	218/928 (23%)
nmy-3	NP_501620.2	Smc	864..>1463	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	3	2.870