Protein Alignment Myo95E and hum-5

DIOPT Version :9

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_497809.1
• Gene: hum-5 / 175521
• WormBaseID: WBGene00002038
• Length: 1017
• Species: Caenorhabditis elegans
• Alignment Length: 1322
• Identity: 320/1322 - (24%)
• Similarity: 530/1322 - (40%)
• Gaps: 383/1322 - (28%)

  Fly     6 GTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQL 70
            |..|.|||..:...|.:.|:..|:::..||||||..:||:|||..:..:....|..|..:.|::.
 Worm    12 GVEDLVLLSTIDLKSVVQNLQLRFQKGRIYTYIGEVLVAVNPYRQLGIYEKSTVDQYKGREIYER 76

  Fly    71 PPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQS 135
            .||::.:.:.||:|:|....|.|::::||||||||||.|:|:.:|
 Worm    77 APHVFAIADAAYRSMKRFGRDSCIVISGESGAGKTETSKIIMKYL-------------------- 121

  Fly   136 STSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQS 200
                                                                             
 Worm   122 ----------------------------------------------------------------- 121

  Fly   201 RRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAV 265
                                                                             
 Worm   122 ----------------------------------------------------------------- 121

  Fly   266 PTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTES 330
                                                    .|.||            :||
 Worm   122 ----------------------------------------AAITN------------VRQ----- 129

  Fly   331 QPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMREC 395
            |.|.||.::.|:.|                                                 .|
 Worm   130 QGEIERVKNVLLRS-------------------------------------------------NC 145

  Fly   396 VTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFH 460
            :      |||.|.|.|.:|:||||:||...|..|:.|||:|.:|::|:|||:|:.....||||||
 Worm   146 I------LEAFGCAKTTRNDNSSRFGKYMHINFDYDGDPVGGNISNYLLEKSRVVRQQEGERNFH 204

  Fly   461 IFYQLLLGADLQLLKSLKLYRNVEKYELLR----NTTAMEEDRMNFHYTKRSL-DVLGLSCEESN 520
            :||||:.|.|..||:...|.::.::|..|.    :..|...|..:|...:.:| .:.....::..
 Worm   205 VFYQLVNGGDDGLLRQFGLTKDAKQYYFLNQGQSHKVASINDSRDFAEVQTALRSIHTFDKQDVE 269

  Fly   521 SIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTNSAQ 585
            |::.|||.::.|||..|:...|..|  ...::....:|..|:.||:....|...|  ::...:|.
 Worm   270 SMWSVIAGLIHLGNVRFIDGENSSG--AVHIAEKAALQNAARCLNVTPDELAKSL--SSQVVAAH 330

  Fly   586 ED-VGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESL---KSTQREKN--LALLDFYGFEAL 644
            .| |..:.|...|...|:.|.:.||.|||:|:|:|:||::   .|::..|:  :.:||.||||..
 Worm   331 GDIVKKQHDVNAAYYTRDALAKALYERLFSWMVSKVNEAISVQNSSRYSKSHVIGVLDIYGFEIF 395

  Fly   645 DHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGILSL 709
            ..|||||..|||..||:.|.|:..||:.|||.|.|||::|.:|:||:|:.||:|::.|..||||:
 Worm   396 GTNSFEQLCINYCNEKLQQLFIELVLKQEQEEYEREGIKWVKIEYFNNKVICDLVEIPRTGILSI 460

  Fly   710 INEPHL---NSNDALLL-RVQQCCAGHPNF----MTTGSNSMCFQ---IRHYASVVNYSIHRFLE 763
            ::|...   |..|.:.| .:.:....|.::    :.....||.|:   |.|||..|.||:..|::
 Worm   461 LDEACASIGNVTDKVFLGELDKKLKSHKHYTSRNLKQSDKSMGFEEFKITHYAGDVTYSVMGFMD 525

  Fly   764 KNSDMLPKYISAAFYQSKLSLVQSLFPEGN-PRRQVTKKPSTLSSNIRTQLQTLLAIVKHRRSHY 827
            ||.|.|.:.:....|.||..||:||||:|: ...:|.::|.|.....:..:..|:..:..:..||
 Worm   526 KNKDTLFQDLKRLLYHSKNRLVKSLFPDGSKSMAEVNRRPPTAGFLFKNSMSELVKQLAQKEPHY 590

  Fly   828 VFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWPHFH 892
            :.||||||.|..:.||:..|:|||||:.|:..|.:.|.|..:.:.:.:|.:||||:.:.|||:..
 Worm   591 IRCIKPNEEKNSNVFDLERVEHQVRYLGLLENVRVRRAGFAHRMPYDRFVNRYKLICASTWPNPR 655

  Fly   893 GGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYHAR 957
            .|.|::...:.|......:.:...|...:|:|||:||:.||:.|..::..:...:|.|.|....|
 Worm   656 RGQQLKDSCMQILESAGLAQDCVQGRTKIFIRSPQTVFRLEELRTEQLPNVITFLQKMVRGVQQR 720

  Fly   958 KRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAIDIIGRY 1022
            :|::||...:.|| .|:|.::.         :.::|.|....|:..|.....:.:|
 Worm   721 ERYRRMLAVRKII-GAYRRYKL---------KSYIWQLINAFRDVRRMRDLGKSIR--------- 766

  Fly  1023 YRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIYHRWKCYIYRNSFDQTARN 1087
                                        ||..|..||.....||.::.||:............|.
 Worm   767 ----------------------------WPAPPLVLAQFVSRLRVMHQRWRAATILARMPPHLRA 803

  Fly  1088 RMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAETNDQY-------------- 1138
            .:.:|:.|..:..::|.::|.:  ..:.|||:    :||.:.....|...|
 Worm   804 SLPQKIAAFEVLNNKKENWGYT--RMWRGDYL----SQQEELELPTTVSTYHDGIQALRQSHPFG 862

  Fly  1139 -VVFADIINKIARSSGKFVPILLVLSTSSLLLLDQRTLQIKYRVPASEIYRMSLSPYLDDIAVFH 1202
             |:|:..:.|..:.:...:.:|:|.......|.:::...:|..:|...|.|:|:....:.:.|.|
 Worm   863 KVLFSTYVQKFNKFNKSSLRVLIVTDRFVAKLENKKFKLLKEPIPLQSISRISVCAESNGLFVIH 927

  Fly  1203 V---------KASEFGRKKGDFVFQTGHVIEIVTKMFL-----VIQNAT-----GKPPEIHISTE 1248
            |         |.::...:.|:.:   |.::....|:.:     :||:|.     ||...|.:
 Worm   928 VGDNDIVGCAKNTKNEERVGEMI---GTLLAHYDKITMRRSPVLIQSAVVCTLGGKTRTIRV--- 986

  Fly  1249 FEANFGQQTVIFSFKYGGMSDL 1270
            |:|.......:|. |.|...||
 Worm   987 FDAENNNVPPVFK-KNGNDVDL 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	38/98 (39%)
		Motor_domain	403..924	CDD:277568	189/543 (35%)
		Myosin_TH1	1092..1267	CDD:283635	40/208 (19%)
hum-5	NP_497809.1	MYSc	6..699	CDD:214580	251/952 (26%)
		MYSc_Myo1	26..687	CDD:276829	239/926 (26%)
		Myosin_TH1	808..986	CDD:283635	35/186 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720