DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo95E and spe-15

DIOPT Version :9

Sequence 1:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_490856.1	Gene:	spe-15 / 171712	WormBaseID:	WBGene00004969	Length:	1219	Species:	Caenorhabditis elegans

Alignment Length:	1438	Identity:	288/1438 - (20%)
Similarity:	466/1438 - (32%)	Gaps:	589/1438 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TW-----------DSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISE-HSLDNV 59
            ||           |:..|.:|:|.:.:||...||....||||:...::::|||..|.. :|.:.:
Worm    55 TWACEEDPQKSVEDNCALVHLNEATLLNNCRLRYANGKIYTYVANILISINPYQLIDGLYSPETI 119

  Fly    60 RNYGDKGIFQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHC 124
            :.|..|.:.|:.|||:.:.:.||:.::.....|.::::|||||||||:.|.::.:|
Worm   120 KEYRGKSLGQMEPHIFAIADKAYREMRRIKTSQSIIVSGESGAGKTESQKAVLKYL--------- 175

  Fly   125 PPTPNVLRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRS 189
                                                   |:|            .....||.|:
Worm   176 ---------------------------------------CEN------------WGTDAGPIQQ- 188

  Fly   190 RTRAESIERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMP 254

Worm   189 ----------------------------------------------------------------- 188

  Fly   255 AAAKGSPKYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSC 319
                                         :.||                     |||
Worm   189 -----------------------------RLLE---------------------TNP-------- 195

  Fly   320 SNLMRQHSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRR 384

Worm   196 ----------------------------------------------------------------- 195

  Fly   385 HKSPTQRMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRI 449
                             .|||.|||.||:||||||:||...|.....|...|..::||:||.:|:
Worm   196 -----------------ILEAFGNAKTLRNNNSSRFGKFVQIHFSDNGTVAGGFVSHYLLETSRV 243

  Fly   450 TDPIIGERNFHIFYQLLLGADLQLLKSLKLYR----NVEKYE----LLRNTTAMEEDRMNFHYT- 505
            .....||||:||||||:.|:...|.|.|:|..    |..|:.    .:.:.::::.|...|..|
Worm   244 CRQAAGERNYHIFYQLIAGSSPDLYKKLRLAPASSFNYLKHGATLFFVNSKSSLKTDASRFSETN 308

  Fly   506 -----------------KRSLDVLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSN 553
                             :|:|.:.|:|.:|...|:..:|.:|.|||..|....: |...||.:::
Worm   309 SSVSDSIISDIDDFAKLERALALSGVSDDEKMFIWSTVAGILHLGNIEFEENAS-DSRGGCMITS 372

  Fly   554 VYE--VQETAQLLNMEAQ--ILINCLTRANSTNSAQED--VGCEMDARQAATNRNTLCRTLYSRL 612
            ..|  :...|:||.:|.:  .|..|.....:|....:.  :...:.|.:|:..|:.|.:.:||:|
Worm   373 GTENSLMAAAELLGLEPEEMKLGLCARIMQTTKGGVKGTLIRVPLKAHEASAGRDALAKAIYSKL 437

  Fly   613 FTWLVNKINESLKSTQREKNLALLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELY 677
            |.|||.:||:|:...:....:.:||..|||....||||||.||:..||:...|...:|:.|||:|
Worm   438 FDWLVAQINKSIPFEKSTGYIGVLDVAGFEYFAVNSFEQFCINFCNEKLQHFFNERILKQEQEMY 502

  Fly   678 IREGLEWSRIDYFDNESICELIDKPSYGILSLINEPHLNSNDALLLRVQQCCAGHPNFMTTG--S 740
            ..|||...:|::.||....||.:|.:.|:..|::|      :|.|.|     |...:|....  |
Worm   503 EAEGLNIQKIEFTDNLDCIELFEKKASGLFDLLDE------EAKLPR-----ATFQHFTQRAHES 556

  Fly   741 NSMCFQ----------------------IRHYASVVNYSIHRFLEKNSDMLPKYISAAFYQSKLS 783
            |...|:                      |||||..|.|....|:|||:|.|...:.....||...
Worm   557 NKNHFRLDAPRKSKVKSHREMRDDEGLLIRHYAGTVCYETRYFVEKNNDQLHNSLEMLIEQSSFP 621

  Fly   784 LVQSLFPE---GNPRRQVTKKPSTLSSNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMA 845
            ||.|||..   |..:.....|..::.:..::||.:||..:.:..:|:|.|:|||...:...||.:
Worm   622 LVVSLFTSEATGAVKTGGRLKAVSVGAKFKSQLSSLLDKLNNTGTHFVRCVKPNSQMKAWHFDGS 686

  Fly   846 LVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWPHFHGGSQVEGIALIIRNLP-- 908
            .:..|::...:..::.|.:.|..........:..|:                       :|||
Worm   687 AILGQLQCAGMASVLRLMQEGFPSRTSFADLYAMYE-----------------------KNLPPS 728

  Fly   909 ------------------LPSAEFTIGTKNVFV-------------RSPRTVYEL---------- 932
                              |...:|..|...||.             :.|.||.||
Worm   729 LARLDPRLFSKCLFHALGLDQNDFQFGNTKVFFTAGKFAEFDQMMKQDPETVMELISKVTDWLVK 793

  Fly   933 EQFRRLRISELAVL---------------IQTMFRMYHARKRFQRMRHSQMII------------ 970
            .::|:::....:|:               ||...|.|..||||    |.::.|
Worm   794 ARWRKVQYGAWSVIKLKNKILYRAEKIKKIQAWIRGYLVRKRF----HKRLAIFRKACALLENSR 854

  Fly   971 ----------SSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAIDIIGRYYRQ 1025
                      .|:...|||.....  ||  .|..|.:..:.:..:.:..|.|:...|.:.|
Worm   855 EMTDILARMNESSQDKWREAADST--TG--ELDELVKTIKNDDLNTEIDRAVKCYEDCVKR---- 911

  Fly  1026 WKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIYHRWKCYIYRNSFDQTARNRMR 1090
              :...:..:.|:|..:.              ||:..|             .|...:...|....
Worm   912 --VDSIIADLKLQLENDE--------------LAEVER-------------ARKEAEDKERREAE 947

  Fly  1091 EKVTA---SIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAETNDQYVVFADIINKIARSS 1152
            ||..|   .|:  .||....|.....   :| .|:...|.:|:.||..::
Worm   948 EKAAAEQEKIL--RRKMEEEREKAQK---EY-ELQLEMQKQKLAAEAEEE--------------- 991

  Fly  1153 GKFVPILLVLSTSSLLLLDQRTLQIKYRVPASEIYRMSLSPYLDDIAVFHVKASEFGRKKGDFVF 1217
                             :.:|..:.:.|:.|:...|::.|   |.:|
Worm   992 -----------------VKRRNKEERDRLDAAVSSRLASS---DGVA------------------ 1018

  Fly  1218 QTGHVIEIVTKMFLVIQNATGKPPEIHISTEFEANFGQQTV--IFSFKYGGMSDLAQGPPKVTRK 1280
                         ||.|.|:..||:            ||:.  :.::||..:.|       ....
Worm  1019 -------------LVAQEASAAPPK------------QQSKYDLGNWKYADLRD-------AINT 1051

  Fly  1281 ANRMEIIV 1288
            :|.||::|
Worm  1052 SNDMELLV 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	33/99 (33%)
		Motor_domain	403..924	CDD:277568	168/612 (27%)
		Myosin_TH1	1092..1267	CDD:283635	29/179 (16%)
spe-15	NP_490856.1	Myosin_N	12..49	CDD:367160
		MYSc_Myo6	78..761	CDD:276833	210/983 (21%)
		IQ	<820..837	CDD:197470	8/20 (40%)
		MAP7	<929..>1000	CDD:368554	18/121 (15%)
		Myosin-VI_CBD	1123..1211	CDD:374599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920