Protein Alignment Myo95E and hum-7

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001248880.1
• Gene: hum-7 / 171650
• WormBaseID: WBGene00002040
• Length: 1880
• Species: Caenorhabditis elegans
• Alignment Length: 1150
• Identity: 241/1150 - (20%)
• Similarity: 399/1150 - (34%)
• Gaps: 406/1150 - (35%)

  Fly    13 LENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNY-GDKGIFQLPPHIYG 76
            |..|:|.:.::|:.:|:...|||||||..:||:||:.....::....|.| ..|.:..|||||:.
 Worm   175 LPELTEQTLLDNLRERFANGHIYTYIGPILVAVNPFCFFPIYNPKYARLYFQSKRLGSLPPHIFA 239

  Fly    77 LTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSSTSSAS 141
            :.::.|.::....|:|||:::||||:||||:
 Worm   240 IADVCYHNMLRIKENQCVVISGESGSGKTES---------------------------------- 270

  Fly   142 GLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSRRHMRE 206
                                                                             
 Worm   271 ----------------------------------------------------------------- 270

  Fly   207 KIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVPTVYGG 271
                   ::|..|..||                               .:.|||.         |
 Worm   271 -------TNHLMSHLIS-------------------------------LSQKGST---------G 288

  Fly   272 CRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQPERER 336
            |
 Worm   289 C---------------------------------------------------------------- 289

  Fly   337 DRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECVTCADV 401
                   ||::..|                   |..|.
 Worm   290 -------STEQTLL-------------------SAGPV--------------------------- 301

  Fly   402 FLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHIFYQLL 466
             |||.|||.||.||||||:||...|.....|...|.::..|:|||:||.....||||:|:||.||
 Worm   302 -LEAFGNAVTLTNNNSSRFGKFIKINYRENGMVSGANVEIYLLEKSRIIFQTKGERNYHVFYYLL 365

  Fly   467 LGADLQLLKSLKLYRNVE-KYELLRNTTAME--EDRMNFHYTKRSLDVLGLSCEESNSIFRVIAV 528
            .|||.:..|...|.:..: ||.......|:|  .:|..|...:.::..:|...:...:||.:|:.
 Worm   366 EGADEEERKKYFLLKPHDYKYLNQNEPFALEGVNERNEFDRLRHAMSSVGFCAKTQQTIFGIISA 430

  Fly   529 VLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTNSAQEDVGCEMD 593
            ||.|||..::........|...:.|...|...|.||:::...|:..||........ |.|.....
 Worm   431 VLLLGNITYIKRHGYHSDESGYIENEEVVDLVANLLHIKTDTLMQALTMKRHVMKT-ETVVLRYS 494

  Fly   594 ARQAATNRNTLCRTLYSRLFTWLVNKINESLK----STQREKNLALLDFYGFEALDH--NSFEQF 652
            ..:|...|:.:.:.:|:.||.::|.:||::|.    |..:...:.:||.:|||.:..  |||||.
 Worm   495 VSEATNTRDAMAKCIYNSLFHYIVLRINQALLKKDFSAGKGYYIGILDIFGFEDVGSQCNSFEQL 559

  Fly   653 AINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGILSLIN-EPHLN 716
            .|||:.||:...|..|:.:.|||.|::||:.|:.|:|.||....:|.....||||.|:: |.::|
 Worm   560 CINYANEKLQSYFNQHIFQFEQEEYLKEGISWTNIEYTDNTECVQLFQSKPYGILRLVDEESNIN 624

  Fly   717 --SNDALLLRVQQCCAGHPNFMTTGSNSMCFQIRHYASVVNYSIHRFLEKNSDML---------- 769
              ::|::|.::.|....:..:.|.......|.:.|||..|.|.|..|.|||.|::
 Worm   625 NGTDDSMLAKLNQFLKNNEYYETPQKKEPAFIVAHYAGKVKYQITGFREKNKDLMRQDVLNALKS 689

  Fly   770 ----------------------------------------------------------------- 769
                                                                             
 Worm   690 STSSVMKTLLGIDPVAVHRWNVLRSVFRAMNAFKQSTRKLQKSESAGHLRVMDSIVTSPRRGSDS 754

  Fly   770 --------------PKYISAAFYQS---------------KLSLVQSL--FPEGNPRRQVTKKPS 803
                          |.:...:.:.:               |:||::||  ..|....|::.||||
 Worm   755 ALSAFLRGELRCEVPDFCDTSMFNTIRNQARRTPAGKSDDKMSLLKSLQILKEAIGGRRLAKKPS 819

  Fly   804 TLSSNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHC 868
            ::|......|..|::.:.:...:::.|||.|..|..:.||..::..|:||..::..|.:.|.|:.
 Worm   820 SVSKQFEYSLTRLMSTLANATPYFIRCIKSNNDKIANHFDDNIILRQLRYTGMLETVRIRRAGYS 884

  Fly   869 YHLLHVKFFHRYKLLNSLTWPHFHGG--SQVEGIALIIR-NLPLPSAEFTIGTKNVFVRSPRTVY 930
            ..:.:..|..:|::|       ...|  |.|:.:...|. :..:.:.....||..:|:|....:.
 Worm   885 VRIEYPSFVQQYRIL-------LRNGRDSTVDDVKEYIHSHASIDNDNIQYGTNKIFMRDAEKLI 942

  Fly   931 ELEQFRRLRISELAVLIQTMFRMYHARKRFQRMRHS----QMIISSAWRTWRECRFGIPFTGRRH 991
            ..:...|..:..:..| |..||...||||:.||:..    |.:|..::......:..:.....:.
 Worm   943 LDDHLHRTIMQSIDTL-QRWFRTMLARKRYLRMKEGIIKIQALIRGSFARAEVRKKALAAQTIQC 1006

  Fly   992 LWSLYRVAREEYRSLKYKRQVRWAIDIIGRYYRQWKIRQFLLTIP 1036
            .|..|: .|::|.|      :|.::..:...||...:|:.:..||
 Worm  1007 NWKKYK-QRQKYLS------IRESVIALQSAYRGASVRKRVGEIP 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	37/110 (34%)
		Motor_domain	<403..937	CDD:473979	166/654 (25%)
		Myosin_TH1	1092..1288	CDD:461801
hum-7	NP_001248880.1	RA	28..134	CDD:214612
		MYSc_Myo9	181..936	CDD:276836	213/1026 (21%)
		C1	1234..1284	CDD:410341
		C1_Myosin-IX	1472..1527	CDD:410368
		RhoGAP	1540..1727	CDD:470621