Protein Alignment Myo95E and Myo1b

DIOPT Version :9

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_038938876.1
• Gene: Myo1b / 117057
• RGDID: 70994
• Length: 1149
• Species: Rattus norvegicus
• Alignment Length: 1410
• Identity: 400/1410 - (28%)
• Similarity: 649/1410 - (46%)
• Gaps: 394/1410 - (27%)

  Fly     1 MEQEIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDK 65
            ::..||..|:||||.|:|::||:|:.:|:..:.||||||:.|:::|||..:..:|.:.|.:|.::
  Rat    11 LDNMIGVGDTVLLEPLNEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSLPIYSPEKVEDYRNR 75

  Fly    66 GIFQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNV 130
            ..::|.|||:.|::.||:||:||.:|||:|:||||||||||..|::::::..:
  Rat    76 NFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAV------------ 128

  Fly   131 LRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAES 195
                                                                             
  Rat   129 ----------------------------------------------------------------- 128

  Fly   196 IERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGS 260
                                                                             
  Rat   129 ----------------------------------------------------------------- 128

  Fly   261 PKYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQ 325
                          ||                                       :|:..|.:::
  Rat   129 --------------CG---------------------------------------KGAEVNQVKE 140

  Fly   326 HSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQ 390
            ...:|.|
  Rat   141 QLLQSTP---------------------------------------------------------- 147

  Fly   391 RMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIG 455
                       .|||.|||.|::|:||||:||..|||.||||||:|..|::|:|||:|:.....|
  Rat   148 -----------VLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRG 201

  Fly   456 ERNFHIFYQLL-----------LGADLQLLKSLKLYRNVEKYELLRNTTAM---EEDRMNFHYTK 506
            |||||:|||||           :||..:||..|||.|:..:|..|...:|.   .:|..||...:
  Rat   202 ERNFHVFYQLLSGASEELLRKSMGASEELLHKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVR 266

  Fly   507 RSLDVLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQIL 571
            .::.::|.|..|:.|:..|:|.||||||..|.|.:.::|.:..::.:..|::|..:|.::: |::
  Rat   267 NAMQIVGFSDPEAESVLEVVAAVLKLGNIEFKPESRMNGLDESKIKDKNELKEICELTSID-QVV 330

  Fly   572 INCLTRANSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQ--REKNLA 634
            :.......:..:.||.|...::..||...|:.|.:.||||||:||||:||||:|:..  |:|.:.
  Rat   331 LERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMG 395

  Fly   635 LLDFYGFEALDH--NSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICE 697
            :||.||||..::  ||||||.|||..||:.|.|:...|:.|||.||||.:||:.||||:|..||:
  Rat   396 VLDIYGFEIFENADNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICD 460

  Fly   698 LIDKPSYGILSLINE----PHLNSNDALLLRVQQCCAGHPNFM------------TTGSNSMCFQ 746
            ||:..:.|||::::|    |...:::..|.::.|.||.|.:|.            ||..:| ||:
  Rat   461 LIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTTLPHS-CFR 524

  Fly   747 IRHYASVVNYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRT 811
            |:|||..|.|.:..|::||:|:|.:.:|.|.:::..:|::||||||||.:...|:|.|..|..:.
  Rat   525 IQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAGHALIKSLFPEGNPAKVNLKRPPTAGSQFKA 589

  Fly   812 QLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKF 876
            .:.||:..::.:..:|:.|||||:.|..|.|..:||.||:||:.|:..|.:.|.|:.:...:...
  Rat   590 SVATLMKNLQTKNPNYIRCIKPNDKKAAHIFSESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPC 654

  Fly   877 FHRYKLLNSLTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRIS 941
            ..|||:|...||||:.|.:: .|:.::...|.:|..|::.|...:|:|:|||:::||..|:.|:.
  Rat   655 LERYKMLCKQTWPHWKGPAR-SGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFQLEDLRKQRLE 718

  Fly   942 ELAVLIQTM-----------------------FRMYHARKRFQRMRHSQMIISSAWRTW------ 977
            :||.|||.:                       :|.|..:||:|:::.|.::|.|..|.|
  Rat   719 DLATLIQKIYRGWKCRTHFLLMKRSQVVIAAWYRRYAQQKRYQQIKSSALVIQSYIRGWKARKIL 783

  Fly   978 ------RECRFGIPFTG-----------RRHL-------------WSLY--RVAREEYRSLKYKR 1010
                  :.|:.......           ||.|             |:.:  ..||.|.:.||.:.
  Rat   784 RELKHQKRCKEAATTIAAYWHGTQARKERRRLKDEARNKHAIAVIWAFWLGSKARRELKRLKEEA 848

  Fly  1011 QVRWAIDIIGRYYRQWKIR-------------------------QFLLTIPLRLPPNTLSPLSTE 1050
            :.:.|:.:|..|:...|:|                         ::||.:..::|  :|||:...
  Rat   849 RRKHAVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYLLEMKNKMP--SLSPIDKN 911

  Fly  1051 WPVAP-AFLADASRHLRSIYHRWKCYIYRNSFDQTARNRMREKVTASIIFKDRKASYGRSVGHPF 1114
            ||..| .||....:.|:.|:|.|:|..||:.|....:....||:.||.:|||:||.|..|||.||
  Rat   912 WPSRPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPF 976

  Fly  1115 VGDYVRLRHNQQWKKICAETNDQYVVFADIINKIARSSGKFVPILLVLSTSSLLLLDQRTLQIKY 1179
            .|.|:.:..|.::||: .:..::.::.|:::|||.|::||....:.:|:.::|||.||::.|||.
  Rat   977 QGAYLEINKNPKYKKL-KDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKS 1040

  Fly  1180 RVPASEIYRMSLSPYLDDIAVFHVKASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGKPPEIH 1244
            .||..::.::|:|...|.....|:|.......||||:|.:.|:||:.||::....:.|.:...|.
  Rat  1041 EVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIE 1105

  Fly  1245 ISTEFEANFGQQTVIFSFKYGGMSDLAQGPPKVTRKANR-MEIIV 1288
            ||.||...|.|..|...|..|...:  ...|...||.|| :|:.|
  Rat  1106 ISDEFLVQFRQDKVCVKFIQGNQKN--GSVPTCKRKNNRLLEVAV 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	43/98 (44%)
		Motor_domain	403..924	CDD:277568	214/554 (39%)
		Myosin_TH1	1092..1267	CDD:283635	63/174 (36%)
Myo1b	XP_038938876.1	MYSc_Myo1	29..701	CDD:276829	263/938 (28%)
		IQ	762..784	CDD:197470	5/21 (24%)
		Myosin_TH1	954..1131	CDD:399188	63/179 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5774
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7856
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.920