DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo95E and myo1f

DIOPT Version :9

Sequence 1:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_002938604.1	Gene:	myo1f / 100493342	XenbaseID:	XB-GENE-5909751	Length:	1095	Species:	Xenopus tropicalis

Alignment Length:	1065	Identity:	263/1065 - (24%)
Similarity:	432/1065 - (40%)	Gaps:	324/1065 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QEIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGI 67
            ::.|..|.|||..::||:.:.|:.:||..|:|:||||:.::::||:..:...:...:..|.....
Frog    15 KQSGVDDMVLLSKITEDAIVENLKKRYLDDYIFTYIGSVLISVNPFKQMPYFTEREIELYQGAAQ 79

  Fly    68 FQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLR 132
            ::.|||||.||:..|:::....|:|||:::||||||||...|.|:.:::.:.
Frog    80 YENPPHIYALTDNMYRNMLIDGENQCVIISGESGAGKTVAAKYIMGYISKVS------------- 131

  Fly   133 KQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIE 197

Frog   132 ----------------------------------------------------------------- 131

  Fly   198 RQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPK 262

Frog   132 ----------------------------------------------------------------- 131

  Fly   263 YAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHS 327
                   ||..:..|.|.:..||                        ||
Frog   132 -------GGGSKVQHVKDIILQS------------------------NP---------------- 149

  Fly   328 TESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRM 392

Frog   150 ----------------------------------------------------------------- 149

  Fly   393 RECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGER 457
                     .|||.|||.|::||||||:||.|:|:....|:|.|..|::::|||:|:......||
Frog   150 ---------LLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVSQNENER 205

  Fly   458 NFHIFYQLLLGADLQLLKSLKL-------YRNVEKYELLRNTTAMEEDRMNFHYTKRSLDVLGLS 515
            |||:||||:.||..:..::|.:       |.|..:...:..|    .|:.:|:....::.|:|:|
Frog   206 NFHVFYQLIEGASDEQRQNLGIMTPDYFFYLNQSETYKVEGT----NDKKDFYEMLEAMMVIGVS 266

  Fly   516 CEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQIL------INC 574
            .||...:.::.|.:|.|||..|            |....|...|...||:..|.:|      :|.
Frog   267 AEEQQMVLQISAGILHLGNISF------------QEQGNYAKVECPDLLDFPAYLLGVQKGRLND 319

  Fly   575 LTRANSTNS----AQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQREKNLAL 635
            ...:...:|    ..|.:...::..||:..|:.|.:.||:|:|.:||..||::::....|.::.:
Frog   320 KLTSRKMDSKWGGRSESITVTLNVEQASYTRDALSKALYARVFDFLVESINKAMQKPYEEYSIGV 384

  Fly   636 LDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELID 700
            ||.||||....|.||||.||:..||:.|.|:...|::|||.|:.||:.|:.|:||:|:.:|:||:
Frog   385 LDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVAEGIRWTPIEYFNNKIVCDLIE 449

  Fly   701 ---KPSYGILSLINE----PHLNSNDA---LLLRVQQCCAGHPNFMTTGSN-SMCFQIRHYASVV 754
               .|. ||:|::::    .|.....|   ||.::|.....|.:|    || ::.|.|.|||..|
Frog   450 NKLNPP-GIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHF----SNWNLGFVIHHYAGKV 509

  Fly   755 NYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKK--PSTLSSNIRTQLQTLL 817
            :|.:..|.|:|.|:|...:......|:...:||||||   |....||  |:|..|.|:.|...|:
Frog   510 SYYVEGFCERNRDVLFIDLIELMQSSEYQFIQSLFPE---RLDSDKKSRPTTAGSKIKKQANDLV 571

  Fly   818 AIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKL 882
            ..:.....||:.||||||.|:|..::.:.|:|||.|:.|...:.:.|.|..|..:..||..||.:
Frog   572 NTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGFAYRRVFNKFLQRYAI 636

  Fly   883 LNSLTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLI 947
            |...|||.:.|..: :|:..::|::.:.|.::.:|...|||::|.:::.||:.|..:....|..|
Frog   637 LTQETWPRWRGDER-QGVQHLLRSVNMDSDQYQMGKSKVFVKNPESLFLLEEMRERKFDTFARTI 700

  Fly   948 QTMFRMYHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQV 1012
            |..:|.|.||:::::||.....|...::..|.......|.|.    .|....|.|.|....||:.
Frog   701 QKAWRRYIARRKYEQMREEASNILYGYKERRRNSINRNFVGD----YLGMEDRPELRQFMTKRER 761

  Fly  1013 RWAIDIIGRYYRQWK-IRQFLLTIP 1036
            ....|.:.:|.|::| |::.|:..|
Frog   762 IDFADSVSKYDRRFKSIKRDLILSP 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	35/98 (36%)
		Motor_domain	403..924	CDD:277568	183/550 (33%)
		Myosin_TH1	1092..1267	CDD:283635
myo1f	XP_002938604.1	MYSc_Myo1	31..677	CDD:276829	226/934 (24%)
		Myosin_TH1	717..915	CDD:368706	18/74 (24%)
		PHA03378	<958..>1041	CDD:223065
		SH3_MyoIe_If_like	1042..1094	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920