Protein Alignment Myo95E and myo1h

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_017945451.1
• Gene: myo1h / 100492763
• XenbaseID: XB-GENE-963784
• Length: 1036
• Species: Xenopus tropicalis
• Alignment Length: 1333
• Identity: 332/1333 - (24%)
• Similarity: 541/1333 - (40%)
• Gaps: 376/1333 - (28%)

  Fly     4 EIGTWDSVLLE-NLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGI 67
            ::|..|.|||: :.||.:|::|:.:|::.:.|||||||.:|::|||..:..::...:..|.....
 Frog    25 KVGVQDFVLLDSHTSEAAFMDNLRKRFQENLIYTYIGTMLVSVNPYQELQLYTQRQMELYQGVNF 89

  Fly    68 FQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLR 132
            .:||||||.:.:.||:.:..:..:..:|::||||:|||||.|.|:.:|.     ..||.|.
 Frog    90 IELPPHIYAVADNAYRVMCTERNNHFILISGESGSGKTETSKKILQYLA-----MTCPVTE---- 145

  Fly   133 KQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIE 197
                                                                             
 Frog   146 ----------------------------------------------------------------- 145

  Fly   198 RQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPK 262
                                                                             
 Frog   146 ----------------------------------------------------------------- 145

  Fly   263 YAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHS 327
                                                 :|.||
 Frog   146 -------------------------------------KLQTI----------------------- 150

  Fly   328 TESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRM 392
                    |||..|
 Frog   151 --------RDRLLL--------------------------------------------------- 156

  Fly   393 RECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGER 457
                  ::..|||.|||.|::|:||||:||..|::.|:||.|.|.||..|::||:|:.....|||
 Frog   157 ------SNPVLEAFGNAKTIRNDNSSRFGKYMDVQFDYKGAPAGGHILSYLIEKSRVVHQNPGER 215

  Fly   458 NFHIFYQLLLGADLQLLKSLKLYRNVEKYE-LLRNTTAMEE---DRMNFHYTKRSLDVLGLSCEE 518
            |||||||||.|.:..|::.|.|.||.:.|. |::...|...   |:.|:...:|:..::..:..:
 Frog   216 NFHIFYQLLEGGEDHLIRWLGLERNPQMYSYLIQGECAKVSSICDKTNWKLVRRAFTIIEFTEAD 280

  Fly   519 SNSIFRVIAVVLKLGNFIFVPITNIDGTEG-CQVSNVYEVQETAQLLNMEAQILINCLTRANSTN 582
            ...:|.::|.||.|||     |...:.|.| ..:.|..::|..::||.:...||...||. ....
 Frog   281 IEHLFGIVASVLHLGN-----IKYEEDTHGHAIIRNGSQMQWISKLLGVPVSILQEALTN-KKIE 339

  Fly   583 SAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESL--KSTQREKNLALLDFYGFEALD 645
            :..|:|...::...|...|:.|.:.:|.|.|.|||||||.||  |...::..:.|||.||||..:
 Frog   340 ARSEEVLSPLNLELAYYARDALAKAIYGRSFNWLVNKINSSLANKDPPKKTVIGLLDIYGFEVFE 404

  Fly   646 HNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGILSLI 710
            .||||||.|||..||:.|.|:...|::|||.|..||:||..:.||||:.||:||::...||::::
 Frog   405 TNSFEQFCINYCNEKLQQLFISMTLKAEQEEYEIEGIEWEPVQYFDNKIICDLIEEKYKGIIAIM 469

  Fly   711 NEPHLNSNDA----LLLRVQQCCAGHPNFMT---------TGSNSMCFQIRHYASVVNYSIHRFL 762
            :|..|...:|    .|.::::....||:|:|         ...:.:.|::.|||..|.|....||
 Frog   470 DEECLRPGEATDLSFLAKLEEKVGDHPHFLTRKLADPVARKTIDWVDFRLIHYAGEVTYCAVGFL 534

  Fly   763 EKNSDMLPKYISAAFYQSKLSLVQSLF--PEGNPRRQVTKKPSTLSSNIRTQLQTLLAIVKHRRS 825
            |||:|:|.:.:.....:||..:::..|  .|.:.||    :|.|:::..:..|.:|:.|:..:..
 Frog   535 EKNNDLLYRNLKEVVLKSKNYILRDCFHPTELDNRR----RPETVTTQFKNSLSSLIEILLLKEP 595

  Fly   826 HYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWPH 890
            .|:.|||||..|||.:|:..||:|||:|:.||..:.:.|.|..|...:..|..|||.|...|||:
 Frog   596 TYIRCIKPNNTKQPGKFEDMLVRHQVKYLGLMEHLRVRRAGFAYRRKYEIFLERYKSLCPQTWPN 660

  Fly   891 FHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYH 955
            :.|.:: ||:..:::.|.....|:.:|...:|:|.|||::.......:|..:|...||..::...
 Frog   661 WAGPAR-EGVEKLVKYLGYQPNEYKLGRTKLFIRFPRTLFATVDSFEIRKHQLVSKIQAKYKGCL 724

  Fly   956 ARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAIDIIG 1020
            .::.|::.:.:.:.:.|.||       |:             :||.|.:    ||  .||:..|.
 Frog   725 GKRAFEKKKKAAIKLESCWR-------GV-------------LARREAK----KR--AWAVQTIR 763

  Fly  1021 R-----------------------YYRQ-WKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADA 1061
            :                       ||.. ||:|:       .:|.|.   |...|...|..:...
 Frog   764 KFIVGFINRKNPDADTNKNFFGMMYYNYLWKLRE-------HVPKNV---LDKRWLTPPVAMEKT 818

  Fly  1062 SRHLRSIYHRWKCYIYRNSFDQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQ 1126
            |..|..:..|.....|..:......:::::||..|.|||.:|..|.:|:..||  :..||.....
 Frog   819 SELLHKLCIRNLVRKYCRTITPQRTHQLQQKVVTSQIFKGKKEGYKQSLCQPF--EETRLSEQDI 881

  Fly  1127 WKKICAETNDQYVVFADIINKIARSSGKFVPILLVLSTSSLLLLDQRTLQIKYRVPASEIYRMSL 1191
            ..|:....|...:.:.....|..|...|..|..|:|:.|:..:.:|  .:||.::..|.:..:|:
 Frog   882 NPKVLQLMNYDRIKYGIAAVKYDRHGFKARPRQLLLTQSAAYVTEQ--AKIKQKIEYSGLKGISV 944

  Fly  1192 SPYLDDIAVFHVKASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGKPPEIHISTEFEANFGQQ 1256
            |...|...:.|| :.|..::|||.:.|..|:.|.|||:.::            .|.:......|.
 Frog   945 SNLNDGFLIIHV-SPEDNKQKGDAILQCDHIFEAVTKLCML------------ASKQDAVTIAQG 996

  Fly  1257 TVIFSFK-YGGMSDLAQGPPKVTRKANRMEIIV 1288
            ::.|.|: ..|:.|...|......||....:.|
 Frog   997 SLTFHFQGKEGIIDFTHGAEAQVYKAKNGHLTV 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	43/119 (36%)
		Motor_domain	<403..937	CDD:473979	197/555 (35%)
		Myosin_TH1	1092..1288	CDD:461801	50/196 (26%)
myo1h	XP_017945451.1	MYSc_Myo1	42..693	CDD:276829	239/925 (26%)
		IQCD	729..756	CDD:467745	10/52 (19%)
		Myosin_TH1	849..1029	CDD:461801	50/196 (26%)