Protein Alignment Myo95E and myo1e

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001121497.2
• Gene: myo1e / 100158599
• XenbaseID: XB-GENE-1005591
• Length: 1108
• Species: Xenopus tropicalis
• Alignment Length: 1335
• Identity: 288/1335 - (21%)
• Similarity: 498/1335 - (37%)
• Gaps: 477/1335 - (35%)

  Fly     6 GTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQL 70
            |..|.|||..::|||.::|:.:||..|.|:||||..::::||:..:.......:..|.....::.
 Frog    20 GVDDMVLLSKITEDSIVDNLKKRYMDDFIFTYIGPVLISVNPFKQMPYFGDKEIEMYQGAAQYEN 84

  Fly    71 PPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQS 135
            |||||.|.:..|:::....|:|||:::||||||||...|.|:::::
 Frog    85 PPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYIS------------------- 130

  Fly   136 STSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQS 200
                                                                             
 Frog   131 ----------------------------------------------------------------- 130

  Fly   201 RRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAV 265
                                .:||                                  |.||
 Frog   131 --------------------KVSG----------------------------------GGPK--- 138

  Fly   266 PTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTES 330
                                                                             
 Frog   139 ----------------------------------------------------------------- 138

  Fly   331 QPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMREC 395
                                                                      .|.:::.
 Frog   139 ----------------------------------------------------------VQHVKDI 145

  Fly   396 VTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFH 460
            :..::..|||.|||.|::||||||:||.|:|:....|:|.|..|::::|||:|:.....|||:||
 Frog   146 ILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFH 210

  Fly   461 IFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAMEEDRMN----FHYTKRSLDVLGLSCEESNS 521
            |||||:.||.....:||.: .:::.|..|..:.:.:.|.:|    |..|..:::|:|:|.|....
 Frog   211 IFYQLIEGASKDQRESLGI-TSLDYYNYLNQSGSYKVDDINDKRDFQETMHAMNVIGISAEGQAM 274

  Fly   522 IFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQIL-INCLTRANSTNSAQ 585
            :.:::|.||.|||.            |.:....|...|..:.|...|.:| ||.....:...|.|
 Frog   275 VMQIVAGVLHLGNI------------GFKEKGNYAAVENEEFLAFPAFLLGINQSRLKDKLTSRQ 327

  Fly   586 ---------EDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQREKNLALLDFYGF 641
                     |.:...::..||...|:.|.:.|:||:|.:||:.||:::|....|.|:.:||.|||
 Frog   328 MDSKWGGKSESINVTLNVEQACYTRDALSKALHSRVFDYLVDSINKAMKKDHEEYNIGVLDIYGF 392

  Fly   642 EALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELID---KPS 703
            |....|.||||.||:..||:.|.|:...|::|||.|::||:.|:.|:||:|:.:|:||:   .|.
 Frog   393 EIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPP 457

  Fly   704 YGILSLINE----PHL---NSNDALLLRVQQCCAGHPNFMTTGSNSMCFQIRHYASVVNYSIHRF 761
             |::|::::    .|.   .::..||.::|.....|.:|   .|.:..|.|.|||..|:|.:..|
 Frog   458 -GVMSILDDVCATMHAVGEGADQTLLQKLQMAVGTHEHF---NSWNQGFIIHHYAGKVSYDVDGF 518

  Fly   762 LEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRTQLQTLLAIVKHRRSH 826
            .|:|.|:|...:......|:...:|:|||| |.:.:...:|:|..|.|:.|...|:..:.....|
 Frog   519 CERNRDVLFMDLIELMQSSQQPFMQALFPE-NLQAEKKGRPTTAGSKIKKQANDLVNTLMKCTPH 582

  Fly   827 YVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWPHF 891
            |:.||||||.|:|..::.:.|:|||.|:.|...:.:.|.|:.|..:..||..||.:|...|||.:
 Frog   583 YIRCIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFKKFLQRYAILTKETWPSW 647

  Fly   892 HGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYHA 956
            . |.:.:|:..::.::.:.|.:|.:|...:|:::|.:::.||:.|..:....|..||..:|.|.|
 Frog   648 K-GDEKKGVLHLLHSVNMDSDQFQLGKTKIFIKAPESLFLLEEMRERKYDGYARSIQKAWRKYVA 711

  Fly   957 RKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAIDIIGR 1021
            ||::.:||..
 Frog   712 RKKYVQMREQ------------------------------------------------------- 721

  Fly  1022 YYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIYHRWKCYIYRNSFDQTAR 1086
                                                                             
 Frog   722 ----------------------------------------------------------------- 721

  Fly  1087 NRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAETNDQYVVFADIINKIARS 1151
                    ||.:|.::|.....|:...|:|||:.:....:.::...:.  :.:.|||.:.|..|.
 Frog   722 --------ASDLFLNKKERRRNSINRNFIGDYIGMDERPELRQFVGKR--EKIDFADTVTKYDRR 776

  Fly  1152 SGKFVPILLVLSTSSLLLLDQRTLQ-----------IKYRVPASEIYRMSLSPYLDDIAVFHVKA 1205
            | |.|...|:|:..|:.|:.:..::           :|.::....|..:|||...||..:.|.:.
 Frog   777 S-KGVKRDLILTPKSVYLIGRDKMKQGPEKGLVKEVLKKKIDVERILSVSLSTMQDDFFILHEQE 840

  Fly  1206 SEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGKPP-------EIHISTE----FEANFGQQTVI 1259
            .:   ...:.:|:| ..|.:::|.:  .:....|.|       ::.:..|    :....|.:.|.
 Frog   841 YD---SLLESLFKT-EFISLLSKHY--EEKTQRKLPLKFNNILDMKLKKENWGPWSGGAGSRQVQ 899

  Fly  1260 FSFKYGGMS-----------DLAQGPPKVTRKANR 1283
            |...:|.::           .:.||.||.:|...|
 Frog   900 FIQGFGDLAVLKHSSKVLQVSIGQGLPKNSRPTRR 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	41/116 (35%)
		Motor_domain	<403..937	CDD:473979	184/557 (33%)
		Myosin_TH1	1092..1288	CDD:461801	46/225 (20%)
myo1e	NP_001121497.2	MYSc_Myo1	33..679	CDD:276829	222/928 (24%)
		Myosin_TH1	719..921	CDD:461801	41/338 (12%)
		SH3_MyoIe_If_like	1055..1107	CDD:212761