Protein Alignment Myo95E and myo9aa

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_068078215.1
• Gene: myo9aa / 100006612
• ZFINID: ZDB-GENE-080424-5
• Length: 2584
• Species: Danio rerio
• Alignment Length: 1388
• Identity: 267/1388 - (19%)
• Similarity: 447/1388 - (32%)
• Gaps: 624/1388 - (44%)

  Fly    13 LENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQLPPHIYGL 77
            |.:|:|.:.::|:..|:|::.||||:|:.::.:||:..:..::...|:.|.:..:.:|.||||.:
Zfish   155 LPDLNEKTLLDNLRSRFKQEKIYTYVGSILIVINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAV 219

  Fly    78 TNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSSTSSASG 142
            .::||.::....::||::::||||:|||::    .|||.|     |       |...|....|||
Zfish   220 ADVAYHAMLQSRQNQCIVISGESGSGKTQS----TNFLIH-----H-------LTALSQKGFASG 268

  Fly   143 LVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSRRHMREK 207
            :                                                              |:
Zfish   269 V--------------------------------------------------------------EQ 271

  Fly   208 IVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVPTVYGGC 272
            |
Zfish   272 I---------------------------------------------------------------- 272

  Fly   273 RQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQPERERD 337
                                                                             
Zfish   273 ----------------------------------------------------------------- 272

  Fly   338 RSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECVTCADVF 402
                                 :||                                     |...
Zfish   273 ---------------------ILG-------------------------------------AGPV 279

  Fly   403 LEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHIFYQLLL 467
            |||.|||.|..||||||:||...:.....|...|.::..|:|||:|:......|||:|:||.||.
Zfish   280 LEAFGNAKTAHNNNSSRFGKFIQVNYQESGTVRGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLA 344

  Fly   468 GADLQLLKSLKLYRNVEKYELLRNTTAM----------------------EEDRMNFHYTKRSLD 510
            |...:...:..| :..|:|..|...|..                      |:.:.:|...:.:::
Zfish   345 GTSEEERTAFHL-KKPEEYHYLNQMTKKPHRPHWGNYYENEPQDCFTVEGEDLKHDFERLQLAME 408

  Fly   511 VLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCL 575
            ::|........||.:::.:|.|||..:.  ..|...:...:.|...:...::||.::.::|...|
Zfish   409 MVGFLPTTRKQIFSLLSAILHLGNIRYK--KKIYRDDSIDICNPEVLPVVSELLEVKEEMLFEAL 471

  Fly   576 TRANSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQRE-------KNL 633
            | ...|.:..|.:.......:|.|.|:::.::|||.||.|:|.:||.:|.: ||:       .::
Zfish   472 T-TRKTVTVGEKLIVPYKLAEAGTVRDSMAKSLYSALFDWIVFRINHALLN-QRDLEESAKILSI 534

  Fly   634 ALLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICEL 698
            .:||.:|||..::||||||.||::.|::...|..|:.:.|||.|..||:.|..|||.||.|...|
Zfish   535 GVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRAEGITWHNIDYIDNTSCITL 599

  Fly   699 IDKPSYGILSLINE----PHLNSNDALLLRVQQCCAGHPNFMTTGSNSMCFQIRHYASVVNYSIH 759
            |.|....:|.|::|    |.. :|..||.:.::...|:............|.|:|||..|.|.:.
Zfish   600 ISKKPTALLHLLDEECNFPQA-TNQTLLDKFKRQHEGNSYIEFPAVMEPAFIIKHYAGKVKYGVK 663

  Fly   760 RFLEKNSD-MLPKYIS----------------------------------AAF------------ 777
            .|.|||:| |.|..::                                  .||
Zfish   664 DFREKNTDHMRPDIVALLKSSKNAFICGLIGIDPVATFRWAVLRAYFRAMVAFRDAGKRHVEKRS 728

  Fly   778 ----------------------YQSKLSLVQ---------------------------------- 786
                                  :|..|.::|
Zfish   729 GHDAAAPAVKSVDSFSFLHHPVHQRSLEILQRCKEEKYIQHACFSGSPPLSPHWSPSSTPPAHCT 793

  Fly   787 -SLFPE-------------------------------------GNPRRQ---------------- 797
             |.|.:                                     |.|.||
Zfish   794 HSFFDDSGLTIGLLDGGVNRRNPRTPLSDLQGSNAINQREGWNGRPGRQNRLSSFGSFSEEEGIF 858

  Fly   798 -------------------------------------------------VT---------KKPST 804
                                                             :|         |||.:
Zfish   859 INSTSSKLLERAHGILMRNKNYKMKPSLPKHLLDVKSLKYLSNLTLQDRITKSLLHLHKKKKPPS 923

  Fly   805 LSSNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCY 869
            :|:..:..|..|:..:...:.::|.||:.|..|.|.:|:.:||..|:||..::..|.:.::|:
Zfish   924 ISAQFQASLNKLMETLGQSQPYFVKCIRSNSEKLPLRFNDSLVLRQLRYTGMLETVRIRQSGY-- 986

  Fly   870 HLLHVKF----FHRYKLLNSLTWPHFH-----GGSQV--EGIALIIRNLPLPSAEFTIGTKNVFV 923
               .:|:    |.|          |||     |.:|.  |.|...::.:.|....|.:|...||:
Zfish   987 ---SIKYTFQDFAR----------HFHVLLPEGSNQASQEAIRQYLQQVDLTPEGFQVGRTMVFL 1038

  Fly   924 RSPRTVYELEQFRRLRISEL--------AVLIQTMFRMYHARKRFQRMRHSQMIISSAWRTWREC 980
            |      |:|   |.|:.:|        .|.:|..||....||.|.|:|.:...|.: |  ||.|
Zfish  1039 R------EIE---RQRLQDLLHKEVLSRIVYLQRRFRALLERKNFLRVRQAACQIQN-W--WRSC 1091

  Fly   981 RFGIPFTGRRHLWSLYRVAREEY----------------RSLKYKRQV---RWAIDIIGRYYRQW 1026
            :            ||.|.::.||                |..:.:|::   |.|..:|.|.:|.:
Zfish  1092 Q------------SLQRDSQLEYDMRVQEGAVVCIQSAWRGFRERRRLLLWREASVLIQRTWRLY 1144

  Fly  1027 KIRQFLLTIPLRLPPNTLSPLSTEW---PVAPAFL--ADASRHLRSIYHRWKCYIYRNSFDQTAR 1086
            :.|:..|.|            .|.|   .....||  .||:..|:::   .:.|:.|..|.:..:
Zfish  1145 RQRRAALQI------------QTAWRRHRARELFLRQRDATIRLQAV---GRGYLARQRFRELQK 1194

  Fly  1087 NRMREKVT------ASIIFKDRK 1103
            .|:  |:|      ||::.::.|
Zfish  1195 QRL--KITHLPNGKASLLTEEDK 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	35/109 (32%)
		Motor_domain	<403..937	CDD:473979	173/792 (22%)
		Myosin_TH1	1092..1288	CDD:461801	5/18 (28%)
myo9aa	XP_068078215.1	RA_Myosin-IXa	16..111	CDD:340736
		MYSc_Myo9	161..1039	CDD:276836	213/1163 (18%)
		IQ	1145..1166	CDD:197470	5/32 (16%)
		Activator_LAG-3	<1464..1574	CDD:151935
		C1_Myosin-IXa	2030..2087	CDD:410433
		RhoGAP	2096..2281	CDD:470621