DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38c and mapk14a

DIOPT Version :9

Sequence 1:	NP_996277.1	Gene:	p38c / 2768679	FlyBaseID:	FBgn0267339	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_571797.1	Gene:	mapk14a / 65237	ZFINID:	ZDB-GENE-010202-2	Length:	361	Species:	Danio rerio

Alignment Length:	353	Identity:	157/353 - (44%)
Similarity:	229/353 - (64%)	Gaps:	3/353 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PEFVRVAINESLWEFPDIYEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYR 66
            |.|.|..:|:::||.|..|:.:..:|.|::|.|.......|....|:|:|.|||:....||.|||
Zfish     7 PTFYRQEVNKTIWEVPVQYQNLSPVGSGAYGSVCSAFDAKTGFKVAVKKLSRPFQSIIHAKRTYR 71

  Fly    67 EIRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKRMSDQEIRIILYQI 131
            |:||||||.|.|||.||:|| .||.::.||..||||||||.|||:...:.::::|..::.::|||
Zfish    72 ELRLLKHMRHENVIGLLDVF-TPATSLKEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQI 135

  Fly   132 LRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADKMTDHVGTMWYLAPEIIFLRGQ 196
            ||||||||||.::||||||.|:|||.:.|::||||||:|...|:||.:|.|.||.||||:.....
Zfish   136 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMH 200

  Fly   197 YTKAIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYPL 261
            |...:|:||||||:|||:|.|.||.|.::::|::.::.:.|||....|:.:....:|.|:...|.
Zfish   201 YNVTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPSSLISRMPSHEARTYISSLPQ 265

  Fly   262 RQRCDFHHLFMGYDVQAIDLMEKMLEMVPEKRITAAEAMLHPYLRDLIEPHHHAEDTAPVYDQNF 326
            ..:.:|..:|:|.:.||:||:||||.:..:||||||||:.|||.....:|....|  |..:||:|
Zfish   266 MPKRNFADVFIGANPQAVDLLEKMLVLDTDKRITAAEALAHPYFAQYHDPDDEPE--AEPFDQSF 328

  Fly   327 ENMVLPVKCWKELVSHEIRNFRPDQLDL 354
            |:..|.::.||.....|:.:|.|...|:
Zfish   329 ESRELDIEEWKRQTYEEMISFEPPVFDV 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38c	NP_996277.1	STKc_p38	4..349	CDD:143356	154/344 (45%)
p38c	NP_996277.1	S_TKc	20..305	CDD:214567	135/284 (48%)
mapk14a	NP_571797.1	STKc_p38alpha	7..351	CDD:143382	155/346 (45%)
		S_TKc	25..309	CDD:214567	135/284 (48%)
		TXY	181..183		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920