Protein Alignment p38c and MAPK12

DIOPT Version :10

• Sequence 1: NP_996277.1
• Gene: p38c / 2768679
• FlyBaseID: FBgn0267339
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: NP_002960.2
• Gene: MAPK12 / 6300
• HGNCID: 6874
• Length: 367
• Species: Homo sapiens
• Alignment Length: 348
• Identity: 139/348 - (39%)
• Similarity: 220/348 - (63%)
• Gaps: 7/348 - (2%)

  Fly     4 FVRVAINESLWEFPDIYEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYREI 68
            |.|..:.::.||...:|..::.:|.|::|.|.......|....|:|:|.|||:.|..||..|||:
Human    11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75

  Fly    69 RLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKRMSDQEIRIILYQILR 133
            ||||||.|.|||.||:|| .|...:.:|...|||...|..||.:..:.:::.:..|:.::||:|:
Human    76 RLLKHMRHENVIGLLDVF-TPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLK 139

  Fly   134 GLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADKMTDHVGTMWYLAPEIIFLRGQYT 198
            ||:|||:||::||||||.|:|||.:.|::||||||:|....:||.:|.|.||.|||:|....:||
Human   140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYT 204

  Fly   199 KAIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYPLRQ 263
            :.:|:||||||:||:||.:.||:|.:::.|::.::.:.|||..||:..:..:.::||::|.|..:
Human   205 QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE 269

  Fly   264 RCDFHHLFMGYDVQAIDLMEKMLEMVPEKRITAAEAMLHPYLRDLIEPHHHAEDTAPV--YDQNF 326
            :.||..:.......|::|:||||.:..|:|:||.||:.|||...|    |..||...|  ||.:|
Human   270 KKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL----HDTEDEPQVQKYDDSF 330

  Fly   327 ENMVLPVKCWKELVSHEIRNFRP 349
            :::...:..||.:...|:.:|:|
Human   331 DDVDRTLDEWKRVTYKEVLSFKP 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p38c	NP_996277.1	STKc_p38	4..349	CDD:143356	138/346 (40%)
MAPK12	NP_002960.2	STKc_p38gamma	11..353	CDD:143385	138/346 (40%)
		TXY	183..185		1/1 (100%)