Protein Alignment p38c and MAPK10

DIOPT Version :10

• Sequence 1: NP_996277.1
• Gene: p38c / 2768679
• FlyBaseID: FBgn0267339
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: NP_001304998.1
• Gene: MAPK10 / 5602
• HGNCID: 6872
• Length: 478
• Species: Homo sapiens
• Alignment Length: 361
• Identity: 136/361 - (37%)
• Similarity: 206/361 - (57%)
• Gaps: 24/361 - (6%)

  Fly     3 EFVRVAINESLWEFPDIYEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYRE 67
            :|..|.:.:|.:.....|:.::.:|.|:.|.|........:...|:|:|.|||:.:..||..|||
Human    47 QFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRE 111

  Fly    68 IRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKRMSDQEIRIILYQIL 132
            :.|:|.:||:|:||||||| .|...:.|||.||||..||||:|.:..:.: :..:.:..:|||:|
Human   112 LVLMKCVNHKNIISLLNVF-TPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQML 174

  Fly   133 RGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADK--MTDHVGTMWYLAPEIIFLRG 195
            .|:|::||||::||||||.||.|..:..::||||||:|.....  ||.:|.|.:|.|||:|...|
Human   175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG 239

  Fly   196 QYTKAIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYP 260
             |.:.:|:||||||:.|::..::||.|.:|:.|...:|..:|||..||:..: ....|||:|..|
Human   240 -YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRP 302

  Fly   261 LRQRCDFHHLFMG------------YDVQAIDLMEKMLEMVPEKRITAAEAMLHPYLRDLIEPHH 313
            ......|..||..            ...||.||:.|||.:.|.|||:..:|:.|||:....:|
Human   303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDP-- 365

  Fly   314 HAEDTAP---VYDQNFENMVLPVKCWKELVSHEIRN 346
             ||..||   :||:..:.....::.||||:..|:.|
Human   366 -AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p38c	NP_996277.1	STKc_p38	4..349	CDD:143356	136/360 (38%)
MAPK10	NP_001304998.1	STKc_JNK	63..398	CDD:270840	131/341 (38%)