DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38c and MAPK8

DIOPT Version :9

Sequence 1:	NP_996277.1	Gene:	p38c / 2768679	FlyBaseID:	FBgn0267339	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_001265476.1	Gene:	MAPK8 / 5599	HGNCID:	6881	Length:	427	Species:	Homo sapiens

Alignment Length:	360	Identity:	135/360 - (37%)
Similarity:	202/360 - (56%)	Gaps:	28/360 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FVRVAINESLWEFPDIYEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYREI 68
            |..|.|.:|.:.....|:.::.:|.|:.|.|........|...|:|:|.|||:.:..||..|||:
Human    10 FYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYREL 74

  Fly    69 RLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKRMSDQEIRIILYQILR 133
            .|:|.:||:|:|.||||| .|..::.|||.||:|..||||:|.:..:.: :..:.:..:|||:|.
Human    75 VLMKCVNHKNIIGLLNVF-TPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLC 137

  Fly   134 GLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADK--MTDHVGTMWYLAPEIIFLRGQ 196
            |:|::||||::||||||.||.|..:..::||||||:|.....  ||.:|.|.:|.|||:|...|
Human   138 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG- 201

  Fly   197 YTKAIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYPL 261
            |.:.:|:||||||:.|:|...|||.|.:::.|...:|..:|||..||:..: ....|.|:|..|.
Human   202 YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKL-QPTVRTYVENRPK 265

  Fly   262 RQRCDFHHLFMGYDV--------------QAIDLMEKMLEMVPEKRITAAEAMLHPYLRDLIEPH 312
            .....|..||.  ||              ||.||:.|||.:...|||:..||:.|||:....:|
Human   266 YAGYSFEKLFP--DVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDP- 327

  Fly   313 HHAEDTAP---VYDQNFENMVLPVKCWKELVSHEI 344
              :|..||   :.|:..:.....::.||||:..|:
Human   328 --SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38c	NP_996277.1	STKc_p38	4..349	CDD:143356	135/360 (38%)
p38c	NP_996277.1	S_TKc	20..305	CDD:214567	120/300 (40%)
MAPK8	NP_001265476.1	STKc_JNK	25..360	CDD:270840	130/343 (38%)
		TXY	183..185		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..427
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870