DRSC/TRiP Functional Genomics Resources

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Protein Alignment p38c and MAPK6

DIOPT Version :10

Sequence 1:NP_996277.1 Gene:p38c / 2768679 FlyBaseID:FBgn0267339 Length:356 Species:Drosophila melanogaster
Sequence 2:NP_002739.1 Gene:MAPK6 / 5597 HGNCID:6879 Length:721 Species:Homo sapiens


Alignment Length:382 Identity:110/382 - (28%)
Similarity:175/382 - (45%) Gaps:68/382 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 YEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYREIRLLKHMNHRNVISLLN 84
            |..::.||.|..|.|........:...|:|:::  ....:..|...|||::::.::|.|::.:..
Human    20 YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRRLDHDNIVKVFE 82

  Fly    85 VFHPPAH-------NMMEFQQVYLVTHLMDADLHRYSRSKRMSDQEIRIILYQILRGLKYIHSAG 142
            :..|...       ::.|...||:|...|:.||........:.::..|:.:||:||||||||||.
Human    83 ILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSAN 147

  Fly   143 VVHRDLKPCNIAVNGNSEV-RILDFGLSRMCADKMTDHVG-------TMWYLAPEIIFLRGQYTK 199
            |:||||||.|:.:|....| :|.||||:|: .|....|.|       |.||.:|.::.....|||
Human   148 VLHRDLKPANLFINTEDLVLKIGDFGLARI-MDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTK 211

  Fly   200 AIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYPLRQR 264
            |||:|:.|||.||::|.:.||.|.:.:.|::.::        |.|..:..|..:..|...|:..|
Human   212 AIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLIL--------ESIPVVHEEDRQELLSVIPVYIR 268

  Fly   265 CDF---H----HLFMGYDVQAIDLMEKMLEMVPEKRITAAEAMLHPYLR---------------- 306
            .|.   |    .|..|...:|:|.:|::|...|..|:||.||:.|||:.                
Human   269 NDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFH 333

  Fly   307 ------DLI---EPHHHAEDTAPVYDQNFENMVLPVKCWKELVSHEIRNFRPDQLDL 354
                  |::   |.|.|..:....:|..|.....||.          .||..|::.|
Human   334 IEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPVH----------NNFDIDEVQL 380

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
p38cNP_996277.1 STKc_p38 4..349 CDD:143356 108/375 (29%)
MAPK6NP_002739.1 STKc_MAPK4_6 14..355 CDD:143359 102/345 (30%)
SEG motif 189..191 0/1 (0%)
FRIEDE motif 332..337 0/4 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 701..721
Blue background indicates that the domain is not in the aligned region.

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