DRSC/TRiP Functional Genomics Resources

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Protein Alignment p38c and MAPK4

DIOPT Version :9

Sequence 1:NP_996277.1 Gene:p38c / 2768679 FlyBaseID:FBgn0267339 Length:356 Species:Drosophila melanogaster
Sequence 2:NP_002738.2 Gene:MAPK4 / 5596 HGNCID:6878 Length:587 Species:Homo sapiens


Alignment Length:322 Identity:106/322 - (32%)
Similarity:166/322 - (51%) Gaps:47/322 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 FVRF--LGGGSFGQV-AKVRLRGTENYFAMKRLMRPFEREEDAKGTYREIRLLKHMNHRNVISLL 83
            ||.|  ||.|..|.| :.|..|.... .|:|::.....|  ..|...|||::::.::|.|::.:.
Human    20 FVDFQPLGFGVNGLVLSAVDSRACRK-VAVKKIALSDAR--SMKHALREIKIIRRLDHDNIVKVY 81

  Fly    84 NVFHPPAHN----MMEFQQVYLVTHLMDADLHRYSRSKRMSDQEIRIILYQILRGLKYIHSAGVV 144
            .|..|...:    :.:|...|:|...|:.||.|......::::..::.:||:||||||||||.|:
Human    82 EVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANVL 146

  Fly   145 HRDLKPCNIAVNGNSEV-RILDFGLSRMCADKMTDHVG-------TMWYLAPEIIFLRGQYTKAI 201
            ||||||.||.::....| :|.||||:|: .|:...|.|       |.||.:|.::.....|||||
Human   147 HRDLKPANIFISTEDLVLKIGDFGLARI-VDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAI 210

  Fly   202 DVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTRE-----------FITGISMERSRNY 255
            |:|:.||||||::|.|:||.|.:.:.|::.::..:.....|           |::. :.|..|  
Human   211 DMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFVSS-TWEVKR-- 272

  Fly   256 LEGYPLRQRCDFHHLFMGYDVQAIDLMEKMLEMVPEKRITAAEAMLHPYLRDLIEPHHHAED 317
                |||:      |....:.:|||.:||:|...|..|:||...:.|||:    .|:...||
Human   273 ----PLRK------LLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM----SPYSCPED 320

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
p38cNP_996277.1 STKc_p38 4..349 CDD:143356 106/322 (33%)
S_TKc 20..305 CDD:214567 102/308 (33%)
MAPK4NP_002738.2 STKc_MAPK4_6 14..351 CDD:143359 106/322 (33%)
SEG motif 186..188 0/1 (0%)
FRIEDE motif 328..333
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 373..413
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 499..534
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0660
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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