DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38c and Mapk6

DIOPT Version :9

Sequence 1:	NP_996277.1	Gene:	p38c / 2768679	FlyBaseID:	FBgn0267339	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_056621.4	Gene:	Mapk6 / 50772	MGIID:	1354946	Length:	720	Species:	Mus musculus

Alignment Length:	380	Identity:	107/380 - (28%)
Similarity:	178/380 - (46%)	Gaps:	64/380 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 YEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYREIRLLKHMNHRNVISLLN 84
            |..::.||.|..|.|........:...|:|:::  ....:..|...|||::::.::|.|::.:..
Mouse    20 YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRRLDHDNIVKVFE 82

  Fly    85 VFHPPAH-------NMMEFQQVYLVTHLMDADLHRYSRSKRMSDQEIRIILYQILRGLKYIHSAG 142
            :..|...       ::.|...||:|...|:.||........:.::..|:.:||:||||||||||.
Mouse    83 ILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSAN 147

  Fly   143 VVHRDLKPCNIAVNGNSEV-RILDFGLSRMCADKMTDHVG-------TMWYLAPEIIFLRGQYTK 199
            |:||||||.|:.:|....| :|.||||:|: .|....|.|       |.||.:|.::.....|||
Mouse   148 VLHRDLKPANLFINTEDLVLKIGDFGLARI-MDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTK 211

  Fly   200 AIDVWSVGCILAELITDRVLFRGENYVSQIRCLIN----IMGTPTREFITGISMERSRNYLEGY- 259
            |||:|:.|||.||::|.:.||.|.:.:.|::.:::    :.....:|.::.|.:....:..|.:
Mouse   212 AIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEEDRQELLSVIPVYIRNDMTEPHR 276

  Fly   260 PLRQRCDFHHLFMGYDVQAIDLMEKMLEMVPEKRITAAEAMLHPYLR------------------ 306
            ||.|      |..|...:|:|.:|::|...|..|:||.||:.|||:.
Mouse   277 PLTQ------LLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPTDEPISSHPFHIE 335

  Fly   307 ----DLI---EPHHHAEDTAPVYDQNFENMVLPVKCWKELVSHEIRNFRPDQLDL 354
                |::   |.|.|..:....:|..|.....|:.          .||..|::.|
Mouse   336 DEVDDILLMDETHSHIYNWERYHDCQFSEHDWPIH----------NNFDIDEVQL 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38c	NP_996277.1	STKc_p38	4..349	CDD:143356	105/373 (28%)
p38c	NP_996277.1	S_TKc	20..305	CDD:214567	95/304 (31%)
Mapk6	NP_056621.4	STKc_MAPK4_6	14..355	CDD:143359	100/343 (29%)
		SEG motif	189..191		0/1 (0%)
		FRIEDE motif	332..337		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..657
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..720
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900