DRSC/TRiP Functional Genomics Resources

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Protein Alignment p38c and Nlk

DIOPT Version :10

Sequence 1:NP_996277.1 Gene:p38c / 2768679 FlyBaseID:FBgn0267339 Length:356 Species:Drosophila melanogaster
Sequence 2:NP_001178853.1 Gene:Nlk / 497961 RGDID:1561602 Length:527 Species:Rattus norvegicus


Alignment Length:364 Identity:124/364 - (34%)
Similarity:193/364 - (53%) Gaps:62/364 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 PDIYEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYREIRLLKHMNHRNVIS 81
            ||     |.:|.|:||.|..|.........|:|::...|:.....|..:||:::|....|.||:|
  Rat   140 PD-----RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLS 199

  Fly    82 LLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKR-MSDQEIRIILYQILRGLKYIHSAGVVH 145
            .|::..||  ::..|:::|:||.||.:|||:...|.: :|...:::.||||||||||:||||::|
  Rat   200 ALDILQPP--HIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILH 262

  Fly   146 RDLKPCNIAVNGNSEVRILDFGLSRM----CADKMTDHVGTMWYLAPEIIFLRGQYTKAIDVWSV 206
            ||:||.|:.||.|..::|.||||:|:    .:..||..|.|.:|.||||:.....|:.|||:|||
  Rat   263 RDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSV 327

  Fly   207 GCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYPLRQRCDFHHLF 271
            |||.|||:..|:||:.::.:.|:..:.:::|||        |:|..|...||...       |:.
  Rat   328 GCIFAELLGRRILFQAQSPIQQLDLITDLLGTP--------SLEAMRTACEGAKA-------HIL 377

  Fly   272 MG----------YDV------QAIDLMEKMLEMVPEKRITAAEAMLHPYLRDLIEPHH------- 313
            .|          |.:      :|:.|:.:||...|.|||:|.:|:.||||.:....:|       
  Rat   378 RGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCC 442

  Fly   314 --------HAED----TAPVYDQNFENMVLPVKCWKELV 340
                    :..|    |.|.:|..||..:..|:..||::
  Rat   443 FSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEII 481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
p38cNP_996277.1 STKc_p38 4..349 CDD:143356 124/364 (34%)
NlkNP_001178853.1 Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949 1..304 66/170 (39%)
Sufficient for interaction with DAPK3. /evidence=ECO:0000250|UniProtKB:Q9UBE8 1..125
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..72
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 90..139
Sufficient for interaction with DAPK3. /evidence=ECO:0000250|UniProtKB:Q9UBE8 124..416 106/297 (36%)
STKc_NLK 137..508 CDD:173748 124/364 (34%)
TQE 298..300 1/1 (100%)
Required for homodimerization and kinase activation and localization to the nucleus. /evidence=ECO:0000250|UniProtKB:O54949 428..527 10/54 (19%)
Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949 434..527 10/48 (21%)
Blue background indicates that the domain is not in the aligned region.

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