DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38c and mapk11

DIOPT Version :9

Sequence 1:	NP_996277.1	Gene:	p38c / 2768679	FlyBaseID:	FBgn0267339	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_001002095.1	Gene:	mapk11 / 415185	ZFINID:	ZDB-GENE-040625-75	Length:	361	Species:	Danio rerio

Alignment Length:	361	Identity:	160/361 - (44%)
Similarity:	239/361 - (66%)	Gaps:	14/361 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PEFVRVAINESLWEFPDIYEFVRFLGGGSFGQVAK---VRLRGTENYFAMKRLMRPFEREEDAKG 63
            |.|.|..:|:::||.|:.|:.:..:|.|::|.|..   ||||   ...|:|:|.|||:....::.
Zfish     5 PGFYRQELNKTVWEVPERYQNLTPVGSGAYGSVCSAYDVRLR---QKVAVKKLSRPFQSLIHSRR 66

  Fly    64 TYREIRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKRMSDQEIRIIL 128
            ||||:||||||.|.|||.||:|| .||.::.||.:|||||:||.|||:...:.:|:||:.::.::
Zfish    67 TYRELRLLKHMKHENVIGLLDVF-TPAASLEEFNEVYLVTNLMGADLNNIVKFQRLSDEHVQFLI 130

  Fly   129 YQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADKMTDHVGTMWYLAPEIIFL 193
            ||:|||||||||||::||||||.|:|||.:.|:|||||||:|...|:||.:|.|.||.||||:..
Zfish   131 YQLLRGLKYIHSAGLIHRDLKPSNVAVNEDCELRILDFGLARQTDDEMTGYVATRWYRAPEIMLN 195

  Fly   194 RGQYTKAIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEG 258
            ...|.:.:|:||||||:.||:..:|||.|.:|:.|::.::.::||||.:.:..||.|.::.|::.
Zfish   196 WMHYNQTVDIWSVGCIMGELLKGKVLFPGNDYIDQLKRIMEVVGTPTPDVLKKISSEHAQKYIQS 260

  Fly   259 YPLRQRCDFHHLFMGYDVQAIDLMEKMLEMVPEKRITAAEAMLHPYLRDLIEPHHHAEDTAPVYD 323
            .|...:.|...:|.|.:..|:||::|||.:..:.||:|:||:.|||.....:|....|  ||.||
Zfish   261 LPHMPQQDLGKIFRGANPLAVDLLKKMLVLDCDGRISASEALCHPYFSQYHDPEDEPE--APPYD 323

  Fly   324 QNFENMVLPVKCWKELVSHEIRNF-----RPDQLDL 354
            |..|:....::.|||||..|:.||     :|:.|.:
Zfish   324 QTPESKDRTMEEWKELVFEEVSNFKDPPNKPESLQV 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38c	NP_996277.1	STKc_p38	4..349	CDD:143356	157/352 (45%)
p38c	NP_996277.1	S_TKc	20..305	CDD:214567	134/287 (47%)
mapk11	NP_001002095.1	STKc_p38beta	7..349	CDD:143383	157/347 (45%)
mapk11	NP_001002095.1	S_TKc	23..307	CDD:214567	134/287 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920