DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38c and mapk12a

DIOPT Version :9

Sequence 1:	NP_996277.1	Gene:	p38c / 2768679	FlyBaseID:	FBgn0267339	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_571482.1	Gene:	mapk12a / 30681	ZFINID:	ZDB-GENE-990415-257	Length:	363	Species:	Danio rerio

Alignment Length:	348	Identity:	143/348 - (41%)
Similarity:	219/348 - (62%)	Gaps:	3/348 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PEFVRVAINESLWEFPDIYEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYR 66
            |.:.|..||:::||.||.|:.::.:|.|::|.|.....|.|....|:|:|.|||:.:..||..||
Zfish     7 PGYFRQEINKTIWEVPDRYKDLKQVGTGAYGTVCYALDRRTGAKVAIKKLHRPFQSDLFAKRAYR 71

  Fly    67 EIRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKRMSDQEIRIILYQI 131
            |:||||||.|.|||.|::||.... ::..|...|||...|..||.:..:.:|:|::.::.::||:
Zfish    72 ELRLLKHMKHDNVIGLVDVFTADL-SLDRFHNFYLVMPFMGTDLGKLMKMERLSEERVQYLVYQM 135

  Fly   132 LRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADKMTDHVGTMWYLAPEIIFLRGQ 196
            |:||||||:||::||||||.|:|:|...|::||||||:|....:||.:|.|.||.|||:|.....
Zfish   136 LKGLKYIHAAGIIHRDLKPGNLAINEECELKILDFGLARQTDSEMTGYVVTRWYRAPEVILSWMH 200

  Fly   197 YTKAIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYPL 261
            ||:.:|:||||||:||::..:.||:|.:::.|:..::.:.|||::||...:..|.:|||:...|.
Zfish   201 YTQTVDIWSVGCIMAEMLLGKPLFKGHDHLDQLMEIMKVTGTPSKEFTAKLQSEDARNYVTKLPR 265

  Fly   262 RQRCDFHHLFMGYDVQAIDLMEKMLEMVPEKRITAAEAMLHPYLRDLIEPHHHAEDTAPVYDQNF 326
            .::.|...|....:.|||.::|.||.:.||.|||||||:..|:..:..||....|  ||.||.:.
Zfish   266 FRKKDLRILLPNVNPQAIKVLEGMLLLDPESRITAAEALAFPFFSEFREPEEETE--APPYDHSL 328

  Fly   327 ENMVLPVKCWKELVSHEIRNFRP 349
            :.....::.||.|...||..|:|
Zfish   329 DEADQSLEQWKRLTFTEILTFQP 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38c	NP_996277.1	STKc_p38	4..349	CDD:143356	141/344 (41%)
p38c	NP_996277.1	S_TKc	20..305	CDD:214567	121/284 (43%)
mapk12a	NP_571482.1	PKc_like	9..351	CDD:304357	141/344 (41%)
		S_TKc	25..309	CDD:214567	121/284 (43%)
		TXY	181..183		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920