DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38c and mapk14b

DIOPT Version :9

Sequence 1:	NP_996277.1	Gene:	p38c / 2768679	FlyBaseID:	FBgn0267339	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_001300688.1	Gene:	mapk14b / 266756	ZFINID:	ZDB-GENE-021007-1	Length:	361	Species:	Danio rerio

Alignment Length:	357	Identity:	161/357 - (45%)
Similarity:	234/357 - (65%)	Gaps:	13/357 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PEFVRVAINESLWEFPDIYEFVRFLGGGSFGQV-----AKVRLRGTENYFAMKRLMRPFEREEDA 61
            |.|.|..:|:::||.|:.|:.:..:|.|::|.|     .|..||     .|:|:|.|||:....|
Zfish     7 PTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCSAFDGKAGLR-----VAVKKLSRPFQSIIHA 66

  Fly    62 KGTYREIRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKRMSDQEIRI 126
            |.||||:||||||.|.|||.||:|| .||.::.||..||||||||.|||:...:.::::|..::.
Zfish    67 KRTYRELRLLKHMKHENVIGLLDVF-SPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQF 130

  Fly   127 ILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADKMTDHVGTMWYLAPEII 191
            ::|||||.|||||||.::||||||.|:|||.:.|::||||||:|:..|:||.:|.|.||.||||:
Zfish   131 LIYQILRALKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARLTDDEMTGYVATRWYRAPEIM 195

  Fly   192 FLRGQYTKAIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYL 256
            .....|...:|:||||||:|||:|.|.||.|.:::.|::.::.::|||..|.:..||.|.:|||:
Zfish   196 LNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIMMLVGTPGPELLMKISSESARNYI 260

  Fly   257 EGYPLRQRCDFHHLFMGYDVQAIDLMEKMLEMVPEKRITAAEAMLHPYLRDLIEPHHHAEDTAPV 321
            ...|...:.:|..:|:|.:..|:||:||||.:..:|||||::|:.|||.....:|....|  |..
Zfish   261 SSLPHMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASQALAHPYFAQYHDPDDEPE--ADP 323

  Fly   322 YDQNFENMVLPVKCWKELVSHEIRNFRPDQLD 353
            |||:||:..|.::.||.|...|:.:|.|...|
Zfish   324 YDQSFESRDLEIEEWKSLTYEEVMSFEPPVFD 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38c	NP_996277.1	STKc_p38	4..349	CDD:143356	158/349 (45%)
p38c	NP_996277.1	S_TKc	20..305	CDD:214567	137/289 (47%)
mapk14b	NP_001300688.1	PKc_like	7..351	CDD:304357	159/351 (45%)
mapk14b	NP_001300688.1	S_TKc	25..309	CDD:214567	137/289 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920