DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38c and Mapk9

DIOPT Version :9

Sequence 1:	NP_996277.1	Gene:	p38c / 2768679	FlyBaseID:	FBgn0267339	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_001157143.1	Gene:	Mapk9 / 26420	MGIID:	1346862	Length:	423	Species:	Mus musculus

Alignment Length:	368	Identity:	146/368 - (39%)
Similarity:	212/368 - (57%)	Gaps:	36/368 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EFVRVAINESLWEFPDIYEFVRFLGGGSFGQVAKV--RLRGTENYFAMKRLMRPFEREEDAKGTY 65
            :|..|.:.:|.:.....|:.::.:|.|:.|.|...  .:.|..  .|:|:|.|||:.:..||..|
Mouse     9 QFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGIN--VAVKKLSRPFQNQTHAKRAY 71

  Fly    66 REIRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADL----HRYSRSKRMSDQEIRI 126
            ||:.|||.:||:|:||||||| .|...:.|||.||||..||||:|    |.....:|||     .
Mouse    72 RELVLLKCVNHKNIISLLNVF-TPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMS-----Y 130

  Fly   127 ILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSR-MCAD-KMTDHVGTMWYLAPE 189
            :|||:|.|:|::||||::||||||.||.|..:..::||||||:| .|.: .||.:|.|.:|.|||
Mouse   131 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPE 195

  Fly   190 IIFLRGQYTKAIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRN 254
            :|...| |.:.:|:||||||:||::..:|||.|.:|:.|...:|..:|||:.||:..: ....||
Mouse   196 VILGMG-YKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKKL-QPTVRN 258

  Fly   255 YLEGYPLRQRCDFHHLFMGY------------DVQAIDLMEKMLEMVPEKRITAAEAMLHPYLRD 307
            |:|..|......|..||..:            ..||.||:.|||.:.|:|||:..||:.|||:..
Mouse   259 YVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITV 323

  Fly   308 LIEPHHHAEDTAP---VYDQNFENMVLPVKCWKELVSHEIRNF 347
            ..:|   ||..||   :||...|.....::.||||:..|:.::
Mouse   324 WYDP---AEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38c	NP_996277.1	STKc_p38	4..349	CDD:143356	146/367 (40%)
p38c	NP_996277.1	S_TKc	20..305	CDD:214567	129/304 (42%)
Mapk9	NP_001157143.1	STKc_JNK	25..360	CDD:270840	142/347 (41%)
		TXY	183..185		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	366..423
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	3	2.870