DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38c and Nlk

DIOPT Version :9

Sequence 1:	NP_996277.1	Gene:	p38c / 2768679	FlyBaseID:	FBgn0267339	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_032728.3	Gene:	Nlk / 18099	MGIID:	1201387	Length:	527	Species:	Mus musculus

Alignment Length:	364	Identity:	124/364 - (34%)
Similarity:	193/364 - (53%)	Gaps:	62/364 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PDIYEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYREIRLLKHMNHRNVIS 81
            ||     |.:|.|:||.|..|.........|:|::...|:.....|..:||:::|....|.||:|
Mouse   140 PD-----RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLS 199

  Fly    82 LLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKR-MSDQEIRIILYQILRGLKYIHSAGVVH 145
            .|::..||  ::..|:::|:||.||.:|||:...|.: :|...:::.||||||||||:||||::|
Mouse   200 ALDILQPP--HIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILH 262

  Fly   146 RDLKPCNIAVNGNSEVRILDFGLSRM----CADKMTDHVGTMWYLAPEIIFLRGQYTKAIDVWSV 206
            ||:||.|:.||.|..::|.||||:|:    .:..||..|.|.:|.||||:.....|:.|||:|||
Mouse   263 RDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSV 327

  Fly   207 GCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYPLRQRCDFHHLF 271
            |||.|||:..|:||:.::.:.|:..:.:::|||        |:|..|...||...       |:.
Mouse   328 GCIFAELLGRRILFQAQSPIQQLDLITDLLGTP--------SLEAMRTACEGAKA-------HIL 377

  Fly   272 MG----------YDV------QAIDLMEKMLEMVPEKRITAAEAMLHPYLRDLIEPHH------- 313
            .|          |.:      :|:.|:.:||...|.|||:|.:|:.||||.:....:|
Mouse   378 RGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCC 442

  Fly   314 --------HAED----TAPVYDQNFENMVLPVKCWKELV 340
                    :..|    |.|.:|..||..:..|:..||::
Mouse   443 FSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEII 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38c	NP_996277.1	STKc_p38	4..349	CDD:143356	124/364 (34%)
p38c	NP_996277.1	S_TKc	20..305	CDD:214567	110/305 (36%)
Nlk	NP_032728.3	Required for interaction with TAB2. /evidence=ECO:0000269\|PubMed:20194509	1..304		66/170 (39%)
		Sufficient for interaction with DAPK3. /evidence=ECO:0000250	1..125
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..72
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..139
		Sufficient for interaction with DAPK3. /evidence=ECO:0000250	124..416		106/297 (36%)
		STKc_NLK	137..508	CDD:173748	124/364 (34%)
		TQE	298..300		1/1 (100%)
		Required for homodimerization and kinase activation and localization to the nucleus	428..527		10/54 (19%)
		Required for interaction with TAB2. /evidence=ECO:0000269\|PubMed:20194509	434..527		10/48 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910