DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38c and Mapk8

DIOPT Version :9

Sequence 1:	NP_996277.1	Gene:	p38c / 2768679	FlyBaseID:	FBgn0267339	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_446281.2	Gene:	Mapk8 / 116554	RGDID:	621506	Length:	427	Species:	Rattus norvegicus

Alignment Length:	360	Identity:	134/360 - (37%)
Similarity:	203/360 - (56%)	Gaps:	28/360 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FVRVAINESLWEFPDIYEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYREI 68
            |..|.|.:|.:.....|:.::.:|.|:.|.|........|...|:|:|.|||:.:..||..|||:
  Rat    10 FYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYREL 74

  Fly    69 RLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKRMSDQEIRIILYQILR 133
            .|:|.:||:|:|.||||| .|..::.|||.||:|..||||:|.:..:.: :..:.:..:|||:|.
  Rat    75 VLMKCVNHKNIIGLLNVF-TPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLC 137

  Fly   134 GLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADK--MTDHVGTMWYLAPEIIFLRGQ 196
            |:|::||||::||||||.||.|..:..::||||||:|.....  ||.:|.|.:|.|||:|...|
  Rat   138 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG- 201

  Fly   197 YTKAIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYPL 261
            |.:.:|:||||||:.|::..::||.|.:|:.|...:|..:|||..||:..: ....|.|:|..|.
  Rat   202 YKENVDLWSVGCIMGEMVCLKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL-QPTVRTYVENRPK 265

  Fly   262 RQRCDFHHLFMGYDV--------------QAIDLMEKMLEMVPEKRITAAEAMLHPYLRDLIEPH 312
            .....|..||.  ||              ||.||:.|||.:...|||:..||:.|||:....:|
  Rat   266 YAGYSFEKLFP--DVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDP- 327

  Fly   313 HHAEDTAP---VYDQNFENMVLPVKCWKELVSHEI 344
              :|..||   :.|:..:.....::.||||:..|:
  Rat   328 --SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38c	NP_996277.1	STKc_p38	4..349	CDD:143356	134/360 (37%)
p38c	NP_996277.1	S_TKc	20..305	CDD:214567	119/300 (40%)
Mapk8	NP_446281.2	STKc_JNK	25..360	CDD:270840	129/343 (38%)
		S_TKc	26..321	CDD:214567	119/300 (40%)
		TXY	183..185		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..411
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910