DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment p38c and Mapk7

DIOPT Version :9

Sequence 1:NP_996277.1 Gene:p38c / 2768679 FlyBaseID:FBgn0267339 Length:356 Species:Drosophila melanogaster
Sequence 2:NP_001178476.1 Gene:Mapk7 / 114509 RGDID:621505 Length:812 Species:Rattus norvegicus


Alignment Length:338 Identity:135/338 - (39%)
Similarity:207/338 - (61%) Gaps:10/338 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 DIYEFVRFLGGGSFGQVAKVRLRGTENYFAMKRLMRPFEREEDAKGTYREIRLLKHMNHRNVISL 82
            |.||.:..:|.|::|.|:..|.|.|....|:|::...|:...:||.|.||:::|||..|.|:|::
  Rat    53 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAI 117

  Fly    83 LNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKR-MSDQEIRIILYQILRGLKYIHSAGVVHR 146
            .::..|.. ...||:.||:|..||::|||:...|.: ::.:.:|..|||:||||||:|||.|:||
  Rat   118 KDILRPTV-PYGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHR 181

  Fly   147 DLKPCNIAVNGNSEVRILDFGLSR-MCADK------MTDHVGTMWYLAPEIIFLRGQYTKAIDVW 204
            ||||.|:.||.|.|::|.|||::| :|...      ||::|.|.||.|||::....:||:|||:|
  Rat   182 DLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLW 246

  Fly   205 SVGCILAELITDRVLFRGENYVSQIRCLINIMGTPTREFITGISMERSRNYLEGYPLRQRCDFHH 269
            |||||..|::..|.||.|:|||.|::.::.::|||:...|..:..||.|.|::..|.||...:..
  Rat   247 SVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWET 311

  Fly   270 LFMGYDVQAIDLMEKMLEMVPEKRITAAEAMLHPYLRDLIEPHHHAEDTAPVYDQNFENMVLPVK 334
            ::.|.|.||:.|:.:||...|..||:||.|:.||:|....:|... .|.||.:|..|:...|..:
  Rat   312 VYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDE-PDCAPPFDFAFDREALTRE 375

  Fly   335 CWKELVSHEIRNF 347
            ..||.:..||.:|
  Rat   376 RIKEAIVAEIEDF 388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
p38cNP_996277.1 STKc_p38 4..349 CDD:143356 135/338 (40%)
S_TKc 20..305 CDD:214567 121/292 (41%)
Mapk7NP_001178476.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Required for cytoplasmic targeting. /evidence=ECO:0000250 2..77 9/23 (39%)
STKc_ERK5 49..384 CDD:270842 132/332 (40%)
Required for binding to MAP2K5. /evidence=ECO:0000250 78..139 20/61 (33%)
Necessary for oligomerization. /evidence=ECO:0000250 140..406 104/250 (42%)
TXY. /evidence=ECO:0000250 219..221 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 424..475
Nuclear localization signal. /evidence=ECO:0000250 505..539
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0660
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.