DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33337 and CG10183

DIOPT Version :9

Sequence 1:	NP_996269.2	Gene:	CG33337 / 2768678	FlyBaseID:	FBgn0053337	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_651160.3	Gene:	CG10183 / 42782	FlyBaseID:	FBgn0039093	Length:	685	Species:	Drosophila melanogaster

Alignment Length:	704	Identity:	371/704 - (52%)
Similarity:	486/704 - (69%)	Gaps:	41/704 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVKILSFILLSGLVLIGAIQSEDRSVLEE-----YQRLRKLKPLGIEFADYFQNVTLNDLSLFDS 60
            ||..::.:||.||..|.|      |.|:|     :.||.:.|      ...||::   :..:.|:
  Fly     1 MVNGIAILLLCGLGHIHA------SHLKEELHLVHHRLSRFK------ESLFQDI---NHEIIDT 50

  Fly    61 RLPTQADLLCLNDLTKLVSALQGGQYWAFKMIDAWGGIPSGIFTGNVYDLGNFDECINIKKD--- 122
            |..:.:|..||.|:.:|.:.|:.|.|||.||:|:||..|||:..|..|||||||||:||.::
  Fly    51 RPSSTSDTQCLVDMKELFAGLKTGSYWALKMLDSWGSFPSGLLYGTFYDLGNFDECLNINQEISS 115

  Fly   123 --SIRGKYCFLDVSPAKIL--GVESSLAGILKIKTATCFPASCSATHMNKFVDTILKRILNVSIP 183
              :|:|||||:.|....:|  |:| ||.| ::||.|||||||||||.:..|...:.:..:|.|:
  Fly   116 SQTIKGKYCFMAVPLRDVLDTGIE-SLEG-MQIKIATCFPASCSATQIETFAGQLYQNKVNSSM- 177

  Fly   184 STAMSISDDSCQTAESEPWSGLTILTIVILSLMGVIVAIATLYDYFLVKSQDQLHTAVKLFSARA 248
            |..:||.:|.|||::..||.||||.|:||||::.:||..:|||||||..:| |....:|:.||||
  Fly   178 SFNISIDEDGCQTSDPVPWDGLTIFTVVILSVLTLIVVSSTLYDYFLCTTQ-QTPALIKIISARA 241

  Fly   249 NSCALFRIVVNQSNPNVIECLHGIRCMSLFWVVWIHQYDNVFSAPNINRFRFLSWLQTPFTMFFL 313
            ||.||||:.|..||.|||:||||||||||.|||::|::.....:||||....|:||:.|.:.||:
  Fly   242 NSRALFRLEVGNSNSNVIDCLHGIRCMSLIWVVFLHEHMYSLISPNINFTYALAWLEKPTSSFFI 306

  Fly   314 EGNFSVDSFFFIGGFLVSLNALGTMEKNNGKINVPRMYIRRFIRIFPILAMSILVYTQLTGVLGD 378
            .|.||||:|.||||.||||.||.||||.|||:|:||||:.|.|||.|:|||:||:|.:|..|:..
  Fly   307 HGYFSVDTFLFIGGLLVSLTALRTMEKTNGKLNIPRMYVHRIIRILPVLAMAILIYVKLMPVVSG 371

  Fly   379 GPLFKGGYSKKASCAKTWYMTLLFVVNFANDMCLDHTWYLAVDMQLFLISPILLFALYKWGKKAA 443
            |||||.|:..|..|...||..|||:.|:|...|||.:|||||||||:::||:|||.|||||||||
  Fly   372 GPLFKSGFHGKEECVNGWYWDLLFIQNYATKTCLDQSWYLAVDMQLYILSPLLLFGLYKWGKKAA 436

  Fly   444 AAIGVLIVLLSGCLFATMMVNHYSIK----SLDFSLQKKTYFYTHTHAAPWLIGFLYGYFVFLNK 504
            .||..::||||||||||.||||||:.    ..|.....|.|..|||||.|||||||:|||:.:|:
  Fly   437 WAIVGIVVLLSGCLFATQMVNHYSMSIKNGGGDDEANSKLYLATHTHATPWLIGFLFGYFLHMNR 501

  Fly   505 GRKFKMNWIAVWSGWILCLAMLFTSIFALYPKLESGKPWLMTTLEVSSYYTLTRVGWPMAVGWVV 569
            ||||:::|:.:||||.:.|||:||||||.||..:...|.| :||:.|.||||||||||:|:.|||
  Fly   502 GRKFQLSWLVLWSGWFISLAMIFTSIFATYPSAKWSAPPL-STLDESLYYTLTRVGWPLAMCWVV 565

  Fly   570 FACMQGYGGMANTFLSSPLWQPISKLSYSIYIWHSFIQEINKRIVRTNTYFSNYQVMLNFWSTMG 634
            |.|:|||.|:||:|||:|||||:|:||||::|||.|:||||.|.|||:||||:|.|||||||..|
  Fly   566 FVCIQGYCGLANSFLSTPLWQPLSRLSYSVFIWHMFVQEINSRNVRTSTYFSSYTVMLNFWSDFG 630

  Fly   635 FTVLFSYLLYLLIEAPIGGLDRLLRPK--KKAPAENKPMTN---SDRVGEGHGH 683
            .:::.||:|||:||||||||..|....  .|:|...:|:..   :.|.|:...|
  Fly   631 ISLIMSYVLYLIIEAPIGGLHSLWSRTGCTKSPEVVRPVLTFVVNQRNGDEPEH 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33337	NP_996269.2	NRF	85..196	CDD:214781	57/117 (49%)
		Acyl_transf_3	266..645	CDD:280013	232/382 (61%)
		OafA	300..666	CDD:224748	225/371 (61%)
CG10183	NP_651160.3	NRF	75..190	CDD:214781	57/117 (49%)
		OafA	245..647	CDD:224748	246/402 (61%)
		Acyl_transf_3	259..641	CDD:280013	232/382 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458042
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	12	11.800