DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33337 and CG16723

DIOPT Version :9

Sequence 1:	NP_996269.2	Gene:	CG33337 / 2768678	FlyBaseID:	FBgn0053337	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_651159.3	Gene:	CG16723 / 42781	FlyBaseID:	FBgn0039092	Length:	695	Species:	Drosophila melanogaster

Alignment Length:	710	Identity:	376/710 - (52%)
Similarity:	497/710 - (70%)	Gaps:	34/710 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVKILSFILLSGLVLIGAIQSEDRSVLEEYQRLRKLKPLGIEFADYFQNVTLNDLSLFDSRLPTQ 65
            ||.::..:|..|||...|::..|..|.:.|:.:.:|:|||:|||::|:||||..|.:.||:|.:.
  Fly     1 MVNVVGVLLFYGLVATCALELTDPDVSKTYEYISQLRPLGLEFAEFFKNVTLESLGVSDSKLASA 65

  Fly    66 ADLLCLNDLTKLVSALQGGQYWAFKMIDAWGGIPSGIFTGNVYDLGNFDECINIKK----DSIRG 126
            .|.||..:|..:::.:...:.||.|||||||.||:|:.|||::||||||||::|:|    ..|||
  Fly    66 EDELCSVELAAVMNGISLRETWALKMIDAWGSIPNGLLTGNLFDLGNFDECLSIEKVVGGKRIRG 130

  Fly   127 KYCFLDVSPAKILGVESSLAGILKIKTATCFPASCSATHMNKFVDTILKRILNVSIPSTAMSISD 191
            |:|||..:.|:|               |||||||||:|.|..||:.:: .::|::..|..|.||.
  Fly   131 KFCFLLANSARI---------------ATCFPASCSSTQMETFVEQLM-ALINLNSSSLKMRISG 179

  Fly   192 DSCQTAESEPWSGLTILTIVILSLMGVIVAIATLYDYFLVKSQDQLHTAVKLFSARANSCALFRI 256
            .||||:|.|||:||||.||||||||.|||...|::||||......:...||.|||||||.|||||
  Fly   180 ASCQTSEIEPWNGLTIFTIVILSLMCVIVISVTIFDYFLCDDPRSIPAVVKTFSARANSRALFRI 244

  Fly   257 VVNQSNPNVIECLHGIRCMSLFWVVWIHQYDNVFSAPNINRFRFLSWLQTPFTMFFLEGNFSVDS 321
            |.|:||||||||.||||||:||||::.|::....::||:||....:|...||:.|.|.|.|:|||
  Fly   245 VPNKSNPNVIECFHGIRCMTLFWVIYCHEFIFFLTSPNLNRLDLYTWTVKPFSSFVLHGYFAVDS 309

  Fly   322 FFFIGGFLVSLNALGTMEKNNGKINVPRMYIRRFIRIFPILAMSILVYTQLTGVLGDGPLFKGGY 386
            ||.:||.|||:.:|.:|||:.|::|...||:.|.:||.|::|::||:|..:..|:..||:.|.||
  Fly   310 FFVLGGLLVSMISLRSMEKSGGRLNPVLMYLHRILRILPVVAIAILIYMTMMTVVSGGPMLKNGY 374

  Fly   387 SKKASCAKTWYMTLLFVVNFA-NDMCLDHTWYLAVDMQLFLISPILLFALYKWGKKAAAAIGVLI 450
            .....|...|:.||||:.|:| .::|||||||||||||||:||||||.|||.||||||:.|.||:
  Fly   375 HGMEYCLNGWFWTLLFIQNYAVQNICLDHTWYLAVDMQLFIISPILLMALYNWGKKAASGIAVLV 439

  Fly   451 VLLSGCLFATMMVNHYSI-----KSLDFSLQKKTYFYTHTHAAPWLIGFLYGYFVFLNKGRKFKM 510
            ||||||||||.|||||::     ...|....||.|..|||||||||||||:|||:.:|:|:||::
  Fly   440 VLLSGCLFATQMVNHYTLLIKINDGDDGVPNKKLYLATHTHAAPWLIGFLFGYFLHINRGKKFQL 504

  Fly   511 NWIAVWSGWILCLAMLFTSIFALYPKLESGKPWLMTTLEVSSYYTLTRVGWPMAVGWVVFACMQG 575
            :...||.||||.|||||||||||||..:...|.| :|||.|.||||||:.||:|:.|::||||||
  Fly   505 SRPIVWLGWILSLAMLFTSIFALYPASQLTAPPL-STLEESLYYTLTRLAWPLAICWIIFACMQG 568

  Fly   576 YGGMANTFLSSPLWQPISKLSYSIYIWHSFIQEINKRIVRTNTYFSNYQVMLNFWSTMGFTVLFS 640
            |||:||:|||:|||||:|:||||:||||.|:||:|.|.|||||||:||..|..|...:|||||.|
  Fly   569 YGGLANSFLSTPLWQPLSRLSYSMYIWHMFVQEVNSRNVRTNTYFTNYIAMERFCYDLGFTVLMS 633

  Fly   641 YLLYLLIEAPIGGLDRLLRPKKKAPAENKPMTNSDRVG-------EGHGHDVDLSNQREL 693
            |:|||:||||:.|.|.:||.:|..||.||....|:..|       :.:||:.:..|..|:
  Fly   634 YILYLIIEAPLCGFDSILRGRKDPPAPNKANIISNERGMENRDPEDQNGHETNPINISEI 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33337	NP_996269.2	NRF	85..196	CDD:214781	54/114 (47%)
		Acyl_transf_3	266..645	CDD:280013	224/384 (58%)
		OafA	300..666	CDD:224748	217/371 (58%)
CG16723	NP_651159.3	NRF	87..184	CDD:214781	54/112 (48%)
		Acyl_transf_3	254..599	CDD:280013	200/345 (58%)
		OafA	291..644	CDD:224748	211/353 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458046
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	1	0.950	-	0	Normalized mean entropy	S7984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	13	12.750