DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33337 and CG5892

DIOPT Version :9

Sequence 1:	NP_996269.2	Gene:	CG33337 / 2768678	FlyBaseID:	FBgn0053337	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_650959.2	Gene:	CG5892 / 42522	FlyBaseID:	FBgn0038873	Length:	738	Species:	Drosophila melanogaster

Alignment Length:	727	Identity:	331/727 - (45%)
Similarity:	476/727 - (65%)	Gaps:	32/727 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVKILSFILLSGLVLIGAIQ-----SEDRSV-LEEYQRLRKLKPLGIEFADYFQNVTLNDLSLFD 59
            |.|:...:|:.||.:..|:.     :|...: .::||||.|::.|..:|..|::||||:|| :.:
  Fly     1 MAKVSVVVLILGLAVTSALDFGPEINEGNELDAQDYQRLNKVRHLSEQFFSYYKNVTLDDL-VPE 64

  Fly    60 SRLPTQADLLCLNDLTKLVSALQGGQYWAFKMIDAWGGIPSGIFTGNVYDLGNFDECINIKK--- 121
            .||||.:||.|..|..:|.:.|..|..||::|||:||.|||||..|::.|||::||||.|::
  Fly    65 GRLPTVSDLQCYADFAQLTAGLASGSLWAYRMIDSWGSIPSGILKGHLKDLGHYDECIAIEQSAA 129

  Fly   122 --DSIRGKYCFLDVSPAKILGVESSLAGILKIKTATCFPASCSATHMNKFVDTILKRILNVSIPS 184
              .::.||||...:...::||   ::..::.::||.|||||||||:|:..:..:||:::.:.:.|
  Fly   130 SGSTLLGKYCLASLPLQQLLG---NVGRMMNVQTAVCFPASCSATNMDTLLRRVLKQLVGLELNS 191

  Fly   185 TAMSISDDSCQTAESEPWSGLTILTIVILSLMGVIVAIATLYDYFLVKSQDQLHTAVKLFSARAN 249
            ....:|::||:|:|.:.:.|..|..|||||:.|..|.|:|.|||||...|::|...:|:||||||
  Fly   192 NQNLVSENSCKTSERDAYDGGAIAAIVILSVFGGAVIISTFYDYFLCADQNKLPAILKVFSARAN 256

  Fly   250 SCALFRIVVNQSNPNVIECLHGIRCMSLFWVVWIHQYDNVFSAPNINRFRFLSWLQTPFTMFFLE 314
            |.:|||| ..:.||||||||||:|.|||.||.:.|.:....::||||.:...:|.:|||.....|
  Fly   257 SRSLFRI-TTKPNPNVIECLHGLRGMSLIWVCFGHDFIISMTSPNINLYDVYTWAKTPFKDIIQE 320

  Fly   315 GNFSVDSFFFIGGFLVSLNALGTMEKNNGKINVPRMYIRRFIRIFPILAMSILVYTQLTGVLGDG 379
            |.|:|||||||.|.||::.||.:|||..||:|:|.||:.|::|:.||:|:|||:|.:|...||||
  Fly   321 GVFAVDSFFFISGLLVAMVALRSMEKAKGKLNIPLMYLHRYLRLTPIVAVSILLYWKLLPHLGDG 385

  Fly   380 PLF-KGGYSKKASCAKTWYMTLLFVVNFANDM-CLDHTWYLAVDMQLFLISPILLFALYKWGKKA 442
            ||: ...:.....|...||.|||:|.|:|.|. ||.||||||:|.||::|:||||..:||||||.
  Fly   386 PLYGNWNFDSYDRCEGNWYWTLLYVQNYATDSECLAHTWYLAIDTQLYIIAPILLIIVYKWGKKG 450

  Fly   443 AAAIGVLIVLLSGCLFATMMVNHYSIKS-------LDFSLQKKTYFYTHTHAAPWLIGFLYGYFV 500
            ||.:.:|::.|:..||:.:::|:||:.|       .|:|  :....|||..|:.||:|||:|||:
  Fly   451 AAVVLLLLLGLTAYLFSIIVINNYSLISGGGGGGPDDYS--EDLDHYTHNRASGWLVGFLFGYFL 513

  Fly   501 FLNKGRKFKMNWIAVWSGWILCLAMLFTSIFALYPKLESGKPWLMTTLEVSSYYTLTRVGWPMAV 565
            ...:|:..|::..|||.|||.|||.|||.|||:|| ..:||...:.||..:.|.:|:|:.||:.:
  Fly   514 HTIRGKAIKLSRPAVWIGWITCLAFLFTCIFAMYP-YGTGKSKTLPTLNEAFYVSLSRIAWPLGL 577

  Fly   566 GWVVFACMQGYGGMANTFLSSPLWQPISKLSYSIYIWHSFIQEINKRIVRTNTYFSNYQVMLNFW 630
            .||||||||||||:||:||:||||||:||||:..|:.|.|||.:|....|.|||||||.:||.||
  Fly   578 SWVVFACMQGYGGLANSFLTSPLWQPLSKLSFCAYMGHLFIQNLNAGRTRVNTYFSNYDIMLRFW 642

  Fly   631 STMGFTVLFSYLLYLLIEAPIGGLDRLLRPKKKAPAENKPMTNSDRVGEGHGHDVDLSNQRELEG 695
            ...|||||.:|::|:|||||.|||:.|:.|.:: ||....:..::...|.....|||..|..
  Fly   643 QDFGFTVLLAYVMYILIEAPCGGLESLILPNRR-PAPQPKVQAAEPSKEEIPSPVDLEKQTP--- 703

  Fly   696 NDSSADQLAEKS 707
            ..|:|..||..|
  Fly   704 ESSAAIDLANDS 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33337	NP_996269.2	NRF	85..196	CDD:214781	45/115 (39%)
		Acyl_transf_3	266..645	CDD:280013	195/387 (50%)
		OafA	300..666	CDD:224748	189/374 (51%)
CG5892	NP_650959.2	NRF	90..203	CDD:214781	45/115 (39%)
		Acyl_transf_3	272..656	CDD:280013	195/386 (51%)
		OafA	277..685	CDD:224748	203/411 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458062
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	11	10.900