DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33337 and CG14205

DIOPT Version :9

Sequence 1:	NP_996269.2	Gene:	CG33337 / 2768678	FlyBaseID:	FBgn0053337	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_608323.1	Gene:	CG14205 / 32952	FlyBaseID:	FBgn0031034	Length:	713	Species:	Drosophila melanogaster

Alignment Length:	732	Identity:	324/732 - (44%)
Similarity:	466/732 - (63%)	Gaps:	48/732 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVK-----ILSFILLSGLVLIGA---IQSEDRSVL---------EEYQRLRKLKPLGIEFADYFQ 48
            |||     |:|.:::| |.|..|   ::....|.|         :.|..:.:|:.|.:||...:|
  Fly     1 MVKHSTGPIVSLLVMS-LALTSASIRVEHPKNSTLNVGNPEWQSQSYHTISRLRRLAVEFFAQYQ 64

  Fly    49 NVTLNDLSL-FDSRLPTQADLLCLNDLTKLVSALQGGQYWAFKMIDAWGGIPSGIFTGNVYDLGN 112
            |:|::||.. .:.||||..||.||.||..|...:...:.||.:|||:||..||||..|||.||||
  Fly    65 NITISDLYRDKEIRLPTTDDLRCLADLQTLAKDVSDRKLWALRMIDSWGTFPSGILYGNVIDLGN 129

  Fly   113 FDECINI-----KKDSIRGKYCFLDVSPAKILGVESSLAGILKIKTATCFPASCSATHMNKFVDT 172
            ||||:.|     ...:::||||.      ..|.:.||:...|.:|||.||||||||.||:..:..
  Fly   130 FDECLGIDHAVTSTHNVQGKYCL------SKLQLASSIPTFLALKTAVCFPASCSADHMDTMLRR 188

  Fly   173 ILKRILNVSIPSTAMSISDDSCQTAESEPWSGLTILTIVILSLMGVIVAIATLYDYFLVKSQDQL 237
            :|:.:|::.:......:|:.:|:||:.||:..|||.|||:||::.|::.:||:.||.:.:....|
  Fly   189 LLQNLLSIELNPDVPLVSEGTCKTADREPYDALTIFTIVVLSILCVLMVLATVCDYLVCQDDQPL 253

  Fly   238 HTAVKLFSARANSCALFRIVVNQSNPNVIECLHGIRCMSLFWVVWIHQYDNVFSAPNINRFRFLS 302
            :..:|.||||||...|||:|..:||||||:||||||.:|..|||:.|.|...|..||:|..:..:
  Fly   254 NKWIKAFSARANCRILFRLVAPRSNPNVIDCLHGIRVLSFIWVVYGHIYLVSFFGPNMNLVKLDT 318

  Fly   303 WLQTPFTMFFLEGNFSVDSFFFIGGFLVSLNALGTMEKNNGKINVPRMYIRRFIRIFPILAMSIL 367
            |.::|::|......:|||:|||:.|.|:.:.||..||:..||:||..||:.|::|:.|:||::|:
  Fly   319 WRRSPYSMLVQHAAYSVDTFFFLSGLLMVVIALRAMERTKGKLNVSLMYLHRYLRLTPVLALAII 383

  Fly   368 VYTQLTGVLGDGPLF-KGGYSKKASCAKTWYMTLLFVVNFAND-MCLDHTWYLAVDMQLFLISPI 430
            ||..:...:|||||: |..:...:.|..|||.|||:|.|:|.| :||.|:|||||||||::|:||
  Fly   384 VYMSILPRMGDGPLYGKVNFDDYSKCKDTWYWTLLYVQNYATDEICLGHSWYLAVDMQLYIIAPI 448

  Fly   431 LLFALYKWGKKAAAAIGVLIVLLSGCLFATMMVNHYSIKSLDFSLQKKTYFYTHTHAAPWLIGFL 495
            ||..||||||||||.|.|.::||:.|||:.|::...|:.::.....:|.||.|||.|:|:|||.|
  Fly   449 LLICLYKWGKKAAAGILVAMLLLAACLFSIMVIGDVSLIAISEGAMEKIYFSTHTRASPYLIGIL 513

  Fly   496 YGYFVFLNKGRKFKMNWIAVWSGWILCLAMLFTSIFALYPKLESGKPWLMTTLEVSSYYTLTRVG 560
            :|||:.:|:|:.||::.|.|..||:..||:||:.:||:|......:  :...:|.:.|.|.||:.
  Fly   514 FGYFLHVNRGKSFKLSPITVVLGWLTSLALLFSCLFAVYGYAADAE--IPPIVEEAFYLTFTRIA 576

  Fly   561 WPMAVGWVVFACMQGYGGMANTFLSSPLWQPISKLSYSIYIWHSFIQEINKRIVRTNTYFSNYQV 625
            ||:.:.|||||||.||||:||:|||||||||:||||||.||:|.|::.:|..|.|||||||:|||
  Fly   577 WPLGLCWVVFACMHGYGGLANSFLSSPLWQPLSKLSYSAYIFHMFMESLNAGITRTNTYFSDYQV 641

  Fly   626 MLNFWSTMGFTVLFSYLLYLLIEAPIGGLDRLLRPKKKAPAENKPMTNSDRVGEGHGHDVDLSNQ 690
            ||.||...|||||.::.:|:|||||.|.|:.||.|.|: |...:|.             |:.|.:
  Fly   642 MLRFWCDFGFTVLLAFAVYILIEAPFGNLEGLLLPDKR-PCPPRPA-------------VEESKE 692

  Fly   691 RELEGNDSSADQLAEKS 707
            ..:.|..:||..|..|:
  Fly   693 APVGGCSASAPTLENKT 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33337	NP_996269.2	NRF	85..196	CDD:214781	48/115 (42%)
		Acyl_transf_3	266..645	CDD:280013	189/380 (50%)
		OafA	300..666	CDD:224748	184/367 (50%)
CG14205	NP_608323.1	NRF	102..212	CDD:214781	48/115 (42%)
		OafA	269..667	CDD:224748	203/399 (51%)
		Acyl_transf_3	282..660	CDD:280013	189/379 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458063
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	1	0.950	-	0	Normalized mean entropy	S7984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	13	12.750