DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33337 and nrf-6

DIOPT Version :9

Sequence 1:	NP_996269.2	Gene:	CG33337 / 2768678	FlyBaseID:	FBgn0053337	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_495680.1	Gene:	nrf-6 / 174287	WormBaseID:	WBGene00003813	Length:	822	Species:	Caenorhabditis elegans

Alignment Length:	749	Identity:	185/749 - (24%)
Similarity:	309/749 - (41%)	Gaps:	161/749 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GIEFADYFQNVTLNDLSLFDSRLPTQADLLCLNDLTKLVSALQGGQYWAFKMIDAWGGIPSGIFT 104
            |:|:|.:.:            .....:|..|    |.|....:..::|.|.:.||.|.:|:||.:
Worm   122 GVEYATHVE------------EHKNCSDCKC----TPLFQQKKSERHWIFNVFDAMGKVPAGIMS 170

  Fly   105 GNVYDLGNFDEC--INIKKDS----IRGKYCFLDV------SPAKILG-----------VESSLA 146
            ||...:|::..|  |::.|::    .:|:||...:      :|....|           .:.::.
Worm   171 GNNLWVGSWSTCRKIDVVKNAQGQKWKGQYCLATIDAYERDNPLVYFGNMMSGPPDKHCYDKTVK 235

  Fly   147 GILK----------IKTATCFPASCSATHMNKFVDTIL---------KRILNVSIPSTAMSISDD 192
            .:..          :|...|.|.:|:...:.:.:...:         |.:.||.:...|.|.||
Worm   236 NVTDDGFCFALFPVLKFGVCMPNTCTNHDVKQMLSFAIRATEGAVGTKSVCNVDVECRAESYSD- 299

  Fly   193 SCQTAESEPWSGLTILTIVILSLMGVIVAIATLYDYFLVKS--QDQL------HTAVKL---FSA 246
                |.||  :||.:..:.:|....|:|...||||.|:|..  ||:.      |..:|.   ||.
Worm   300 ----AMSE--NGLAMFALYLLIATVVLVTFGTLYDLFIVSKAPQDEKNSSAFNHPFIKFILAFSM 358

  Fly   247 RANSCALFRIVVNQSNPNVIECLHGIRCMSLFWVVWIHQY---------DNVFSAPNINRF--RF 300
            ..|..   .|:.::.|...|..|||:|.:|:.|::..|.|         ||:  .|.:..|  :|
Worm   359 YTNGS---EILQSKKNDREINSLHGVRFLSMCWIILGHTYYYIGTSLTTDNL--VPTLINFPKQF 418

  Fly   301 LSWLQTPFTMFFLEGNFSVDSFFFIGGFLVSLNAL-GTMEKNNG---KINV------PRMYIRRF 355
                   .|...::...:||||||:.|.|.:.:.. .||:.:..   |::.      |..|.:|:
Worm   419 -------HTQIIVQAPLAVDSFFFLSGMLAAFSFFKKTMKADPNHPPKLSAFNWQTWPMYYYKRY 476

  Fly   356 IRIFPILAMSILVYTQLTGVLGDGPLFKGGYSKKASCAKTWYMTLLFVVNFA---NDMCLDHTWY 417
            |||.|...:.:|....|...:.:||.::.  .::..|:..|:..|:::.||.   .:.|:..|||
Worm   477 IRITPTYIIVMLFDVTLFTYISNGPFWRP--IERQGCSIAWWTNLIYLNNFLLQDQECCMGWTWY 539

  Fly   418 LAVDMQ--LFLISPILLFALYKWGKKAAAAIGVLIVLLSGC--LFATMMVNHYSIKSLDFSLQ-- 476
            ||.|||  :||: |:|:....|||.|....:...::.||..  |..|.:..:.....|...||
Worm   540 LANDMQFHIFLM-PLLVIVFLKWGMKVGLGLSTGLIALSSLIRLIITQIYGYPPAPILTAKLQIV 603

  Fly   477 -------KKTYFYTHTHAAPWLIGFLYGYFVFLN-------KGRKFKMNWIAVWSGWILCLAMLF 527
                   ...|...:....|:::|.:..|  .||       |..|.|:....|...|.....:..
Worm   604 YQLNDYWNDVYVRPYIRCTPFIVGIVVAY--LLNAWTTREQKDLKIKLERRTVIICWCTSTVLGL 666

  Fly   528 TSIFALYPKLESG---KPW--LMTTLEVSSYYTLTRVGWPMAVGWVVFACMQGYGGMANTFLSSP 587
            .|:|.||...::|   |||  |.|.....:|        .:|:|||||||..|.||..:|.||..
Worm   667 YSVFGLYWFAKTGDISKPWEILYTIFGTPAY--------ALALGWVVFACTTGNGGPVDTILSWR 723

  Fly   588 LWQPISKLSYSIYIWHSFIQEINKRIVRTNTYFSNYQVMLNFWSTMGF-TVLFSYLLYLLIEAPI 651
            |:.|:||:::..|:.|..:.:|.........:|:.:..|:.:.....| :...::...|..|.|:
Worm   724 LFVPLSKITFCAYLLHPIMLQIYNLSRPQPFHFTTFIQMIRYTVEAVFASYTIAFFFSLAFEKPL 788

  Fly   652 GGLDRLL-RPKKKAPAENKPMT---------NSD 675
            ..:|.:| ..||....||...|         |||
Worm   789 NKIDEMLFNSKKMMNGENGNTTEMVPLNKIRNSD 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33337	NP_996269.2	NRF	85..196	CDD:214781	30/152 (20%)
		Acyl_transf_3	266..645	CDD:280013	112/428 (26%)
		OafA	300..666	CDD:224748	106/405 (26%)
nrf-6	NP_495680.1	NRF	151..288	CDD:214781	24/136 (18%)
		OafA	375..790	CDD:224748	115/436 (26%)
		Acyl_transf_3	375..777	CDD:280013	112/423 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162776
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm14368
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.600