DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p53 and TP73

DIOPT Version :9

Sequence 1:	NP_996267.1	Gene:	p53 / 2768677	FlyBaseID:	FBgn0039044	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_005418.1	Gene:	TP73 / 7161	HGNCID:	12003	Length:	636	Species:	Homo sapiens

Alignment Length:	332	Identity:	79/332 - (23%)
Similarity:	127/332 - (38%)	Gaps:	58/332 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 HKGTDSEDDSTEVDIKEDIPKTVEVSGSELTTEPMAFLQGLNSGNLMQFSQQSVLREMMLQ---- 181
            |..:..|.|||..|:.:......||.|...::..:..|:|:.:..:.||:..|...:.|..
Human    17 HLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAAS 81

  Fly   182 -------------------------DIQIQANTLPKLENHNIGGYCFSMVLDE---PPKSLWMYS 218
                                     |....|..:|...::. |.:.|.:...:   ...:.|.||
Human    82 ASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYP-GPHHFEVTFQQSSTAKSATWTYS 145

  Fly   219 IPLNKLYIRMNKAFNVDVQFKSKMPIQP-LNLRVFLCF--SNDVSAPVVRCQNHLSVEPLTANNA 280
            ..|.|||.::.|  ...:|.|...|..| ..:|....:  :..|:..|.||.||..........:
Human   146 PLLKKLYCQIAK--TCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQS 208

  Fly   281 KMRESLLRSENPN-SVYCGNAQGKGISERFSVVVPLNMSRSVTRSGLTRQTLAFKFVCQNSCIG- 343
            .....|:|.|..| |.|..:.    ::.|.|||||.    ...:.|....|:.:.|:|.:||:|
Human   209 APASHLIRVEGNNLSQYVDDP----VTGRQSVVVPY----EPPQVGTEFTTILYNFMCNSSCVGG 265

  Fly   344 --RKETSLVFCLEKACGDIVGQHVIHVKICTCPKRDRIQDE------RQLN--SKKRKSVPEAAE 398
              |:...::..||...|.::|:.....:||.||.|||..||      :.||  |.|..:..:.|.
Human   266 MNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAF 330

  Fly   399 EDEPSKV 405
            :..|..|
Human   331 KQSPPAV 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p53	NP_996267.1	P53	203..383	CDD:176262	53/195 (27%)
p53	NP_996267.1	P53_C	429..495	CDD:288471
TP73	NP_005418.1	Transactivation. /evidence=ECO:0000250	1..46		9/28 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..104		0/25 (0%)
		P53	113..309	CDD:279242	55/206 (27%)
		DNA-binding. /evidence=ECO:0000255	131..310		52/188 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..345		7/24 (29%)
		Oligomerization. /evidence=ECO:0000255	345..386
		P53_tetramer	345..384	CDD:285011
		Interaction with HIPK2. /evidence=ECO:0000269\|PubMed:11925430	345..380
		PPxY motif	483..487
		SAM_tumor-p73	487..551	CDD:188970
		SAM	491..550	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147025
Domainoid	1	1.000	65	1.000	Domainoid score	I10037
eggNOG	1	0.900	-	-		E1_2C1DX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41285
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11447
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5172
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.830