DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p53 and tp73

DIOPT Version :9

Sequence 1:	NP_996267.1	Gene:	p53 / 2768677	FlyBaseID:	FBgn0039044	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_899183.1	Gene:	tp73 / 368221	ZFINID:	ZDB-GENE-030814-2	Length:	640	Species:	Danio rerio

Alignment Length:	370	Identity:	83/370 - (22%)
Similarity:	132/370 - (35%)	Gaps:	103/370 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 FNLPQSFGNESNEYAHLATPVDPAYGGN-----------------NTNNMMQFTNNLEILANNNS 106
            |.|||:  ..|.:.|..:.|      ||                 |.|.|.|::     |.:::.
Zfish    27 FELPQA--GHSGDRASSSLP------GNRAEVCMDVYHMRDMRDMNDNVMSQYS-----LLSSSM 78

  Fly   107 DGNNKINACNKFVCHKGTDSEDDSTEVDIKEDIPKTVEVSGSELTTEPMAFLQGLNSGNLMQFSQ 171
            |              :|..:...||.       |.:.|.:.:..|..|              :||
Zfish    79 D--------------QGLGNRAASTS-------PYSSETTSNVPTPSP--------------YSQ 108

  Fly   172 QSVLREMMLQDIQIQANT-LPKLENHNIGGYCFSMVLDE---PPKSLWMYSIPLNKLYIRMNKAF 232
            .:...|.|.....|.:|| .|       |.:.|.:...:   ...:.|.||..|.|||.::.|..
Zfish   109 PNSTFEAMSPAPAIPSNTDYP-------GPHNFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTC 166

  Fly   233 NVDVQFKSKMP------IQPLNLRVFLCFSNDVSAPVVRCQNHLSVEPLTANNAKMRESLLRSEN 291
            .:.::..|..|      ..|:..:     :..|:..|.||.||........:.......|:|.|.
Zfish   167 PIQIKLASSPPNGSVIRAMPIYKK-----AEHVTEVVKRCPNHKLGRDFNESQTAPASHLIRVEG 226

  Fly   292 PNSVYCGNAQGKGISERFSVVVPLNMSRSVTRSGLTRQTLAFKFVCQNSCIG---RKETSLVFCL 353
            .|  .|...... ::.|.||:||...    .:.|....|:.:.|:|.:||:|   |:...::..|
Zfish   227 NN--LCQYVDDP-VTGRQSVLVPYES----PQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITL 284

  Fly   354 EKACGDIVGQHVIHVKICTCPKRDRIQDE------RQLNSKKRKS 392
            |...|.::|:.....:||.||.|||..||      :.||....|:
Zfish   285 ETRDGQVLGRRSFEGRICACPGRDRKADEDHFREQQALNESVAKN 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p53	NP_996267.1	P53	203..383	CDD:176262	49/197 (25%)
p53	NP_996267.1	P53_C	429..495	CDD:288471
tp73	NP_899183.1	P53	120..316	CDD:279242	54/214 (25%)
		P53_tetramer	352..391	CDD:285011
		SAM_superfamily	498..557	CDD:301707
		SAM	498..556	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580494
Domainoid	1	1.000	66	1.000	Domainoid score	I9916
eggNOG	1	0.900	-	-		E1_2C1DX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25509
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11447
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5172
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.830