DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p53 and Tp73

DIOPT Version :9

Sequence 1:	NP_996267.1	Gene:	p53 / 2768677	FlyBaseID:	FBgn0039044	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001102166.1	Gene:	Tp73 / 362675	RGDID:	1307083	Length:	684	Species:	Rattus norvegicus

Alignment Length:	459	Identity:	103/459 - (22%)
Similarity:	170/459 - (37%)	Gaps:	79/459 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 AHLATPVDPAYGGNNTNNMMQFTNNLEILANNNSDGNNKINACNKFVCHKGTDSEDDSTEVDIKE 137
            |.|....||    :......:.:|.:..:|.::|..::.    :.|. |..:..|.|||..|:.:
  Rat    23 APLPKSTDP----SRAQVQPRMSNGVGEMAQSSSSSSSS----STFE-HLWSSLEPDSTYFDLPQ 78

  Fly   138 DIPKTVEVSGSELTTEPMAFLQGLNSGNLMQFSQQSVLREMM----------------------- 179
            ......|.:|||.:...:..|||:.|..:.||:..|...:.|
  Rat    79 PSQGNSEATGSEESNMDVFHLQGMTSSVMAQFNLLSSAMDQMGSRAAPASPYTPEHAASAPTHSP 143

  Fly   180 ------LQDIQIQANTLPKLENHNIGGYCFSMVLDE---PPKSLWMYSIPLNKLYIRMNKAFNVD 235
                  ..|....|..:|...::. |.:.|.:...:   ...:.|.||..|.|||.::.|  ...
  Rat   144 YAQPSSTFDTMSPAPVIPSNTDYP-GPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAK--TCP 205

  Fly   236 VQFKSKMPIQP-LNLRVFLCF--SNDVSAPVVRCQNHLSVEPLTANNAKMRESLLRSENPN-SVY 296
            :|.|...|..| ..:|....:  :..|:..|.||.||..........:.....|:|.|..| |.|
  Rat   206 IQIKVSTPPPPGTAIRAMPVYKKAEHVTDIVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQY 270

  Fly   297 CGNAQGKGISERFSVVVPLNMSRSVTRSGLTRQTLAFKFVCQNSCIG---RKETSLVFCLEKACG 358
            ..:.    ::.|.|||||.    ...:.|....|:.:.|:|.:||:|   |:...::..||...|
  Rat   271 VDDP----VTGRQSVVVPY----EPPQVGTEFTTILYNFMCNSSCVGGMNRRPILVIITLETRDG 327

  Fly   359 DIVGQHVIHVKICTCPKRDRIQDE------RQLN--SKKRKSVPEAAEEDEPSKVRRCIAIKTED 415
            .::|:.....:||.||.|||..||      :.||  :.|..:..:.|.:..|.      ||....
  Rat   328 QVLGRRSFEGRICACPGRDRKADEDHYREQQALNESTTKNGAASKRAFKQSPP------AIPALG 386

  Fly   416 TESNDSRDCDDSAAEWNVSRTPDGDYRLAITCPNKEWLLQSIEGMIKEAAAEVLRNPNQENLRRH 480
            |.....|..|:.....:|.    |.....|....||.|  .:..::.:...:..|...|:.|.:.
  Rat   387 TNVKKRRHGDEDMFYMHVR----GRENFEILMKVKESL--ELMELVPQPLVDSYRQQQQQQLLQR 445

  Fly   481 ANKL 484
            .:.|
  Rat   446 PSHL 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p53	NP_996267.1	P53	203..383	CDD:176262	53/195 (27%)
p53	NP_996267.1	P53_C	429..495	CDD:288471	10/56 (18%)
Tp73	NP_001102166.1	P53	158..354	CDD:279242	55/206 (27%)
		P53_tetramer	390..429	CDD:285011	8/44 (18%)
		SAM_tumor-p73	534..598	CDD:188970
		SAM	538..598	CDD:197735
		Gp37	593..>683	CDD:286696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340687
Domainoid	1	1.000	65	1.000	Domainoid score	I9777
eggNOG	1	0.900	-	-		E1_2C1DX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45413
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11447
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.800