DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p53 and tp53

DIOPT Version :9

Sequence 1:	NP_996267.1	Gene:	p53 / 2768677	FlyBaseID:	FBgn0039044	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001258749.1	Gene:	tp53 / 30590	ZFINID:	ZDB-GENE-990415-270	Length:	374	Species:	Danio rerio

Alignment Length:	336	Identity:	74/336 - (22%)
Similarity:	127/336 - (37%)	Gaps:	84/336 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 QSVLREMMLQDIQIQANTLPKLENHNIGGYCFSMVLDE--PPKSL-WMYSIPLNKLYIRMNKA-- 231
            ::||.|..........:|:|:..::. |.:.|.:...:  ..||: ..||..||||:.::.|.
Zfish    48 ENVLEEQPQPSTLPPTSTVPETSDYP-GDHGFRLRFPQSGTAKSVTCTYSPDLNKLFCQLAKTCP 111

  Fly   232 --FNVDVQFKSKMPIQPLNLRVFLCF--SNDVSAPVVRCQNHLSVEPLTANNAKMRESLLRSENP 292
              ..|||     .|.|...:|....:  |..|:..|.||.:|....  ..:|......|:|.|..
Zfish   112 VQMVVDV-----APPQGSVVRATAIYKKSEHVAEVVRRCPHHERTP--DGDNLAPAGHLIRVEGN 169

  Fly   293 NSVYCGNAQGKGISERFSVVVPLNMSRSVTRSGLTRQTLAFKFVCQNSCIG---RKETSLVFCLE 354
            ..   .|.:...|:.|.||.||.    ...:.|....|:...::|.:||:|   |:....:..||
Zfish   170 QR---ANYREDNITLRHSVFVPY----EAPQLGAEWTTVLLNYMCNSSCMGGMNRRPILTIITLE 227

  Fly   355 KACGDIVGQHVIHVKICTCPKRDRIQDERQLNSKKRKSVPEAAEEDEPSKVRRCIAIKTEDTESN 419
            ...|.::|:....|::|.||.|||                                 |||  |||
Zfish   228 TQEGQLLGRRSFEVRVCACPGRDR---------------------------------KTE--ESN 257

  Fly   420 DSRDCDDSAAEWNVSRTPDGDYRLAITCPNKEWLLQSIEGMIKEAAAEVLRNPNQENLRRHAN-- 482
            ..:|.:..    .:::|..|..|                .::||:::..||....:..:..::
Zfish   258 FKKDQETK----TMAKTTTGTKR----------------SLVKESSSATLRPEGSKKAKGSSSDE 302

  Fly   483 KLLSLKKRAYE 493
            ::.:|:.|..|
Zfish   303 EIFTLQVRGRE 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p53	NP_996267.1	P53	203..383	CDD:176262	51/191 (27%)
p53	NP_996267.1	P53_C	429..495	CDD:288471	10/67 (15%)
tp53	NP_001258749.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..81		5/28 (18%)
		P53	64..258	CDD:279242	59/243 (24%)
		Interaction with DNA. /evidence=ECO:0000250	242..249		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..302		15/105 (14%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	275..297		5/37 (14%)
		P53_tetramer	294..335	CDD:285011	3/20 (15%)
		Oligomerization	302..333		3/12 (25%)
		Nuclear export signal. /evidence=ECO:0000250	316..327
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..374
		Basic (repression of DNA-binding)	346..367
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580496
Domainoid	1	1.000	66	1.000	Domainoid score	I9916
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002925
OrthoInspector	1	1.000	-	-		otm25509
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11447
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5172
SonicParanoid	1	1.000	-	-		X6184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.930