DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p53 and tp63

DIOPT Version :9

Sequence 1:	NP_996267.1	Gene:	p53 / 2768677	FlyBaseID:	FBgn0039044	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_694518.1	Gene:	tp63 / 260407	ZFINID:	ZDB-GENE-030819-1	Length:	588	Species:	Danio rerio

Alignment Length:	393	Identity:	86/393 - (21%)
Similarity:	135/393 - (34%)	Gaps:	132/393 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 NLPQSFGNESNEYAHLATPVDPAYGGNNTNNMMQFTNNLEILANNNSDGNNKINACNKFVCHKGT 124
            |.|.|:.........|...:|...|..:|:            ..||....|.:.|.:.:
Zfish     7 NAPSSYSEPQYTSLGLLNSMDQNGGSTSTS------------PYNNDHAQNNVTAPSPY------ 53

  Fly   125 DSEDDST--EVDIKEDIPKTVEVSGSELTTEPMAFLQGLNSGNLMQFSQQSVLREMMLQDIQIQA 187
             ::..||  .:.....||...:.:|      |..|                        |:..|.
Zfish    54 -AQPSSTFEALSPSPAIPSNTDYAG------PHTF------------------------DVSFQQ 87

  Fly   188 NTLPKLENHNIGGYCFSMVLDEPPKSLWMYSIPLNKLYIRMNKAFNVDVQFKSKMPIQPLNLRVF 252
            ::..|                   .:.|.||..|.|||.::.|...:.::..:..| |...:|..
Zfish    88 SSTAK-------------------SATWTYSTELKKLYCQIAKTCPIQIKVLTNPP-QGAVIRAM 132

  Fly   253 LCF--SNDVSAPVVRCQNH-LSVEPLTANNAKMR--ESLLRSENPNSVYCGNAQGK----GISER 308
            ..:  :..|:..|.||.|| ||.|   .|:.::.  ..|:|.|       ||:..:    .|:.|
Zfish   133 PVYKKAEHVTEVVKRCPNHELSRE---FNDGQIAPPSHLIRVE-------GNSHAQYVEDSITGR 187

  Fly   309 FSVVVPLNMSRSVTRSGLTRQTLAFKFVCQNSCIG---RKETSLVFCLEKACGDIVGQHVIHVKI 370
            .||:||.    ...:.|....|:.:.|:|.:||:|   |:...::..||...|.::|:.....:|
Zfish   188 QSVLVPY----EPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARI 248

  Fly   371 CTCPKRDRIQDE-------------------------RQLNS-KKRKSVPEAAEEDEPSKVRRCI 409
            |.||.|||..||                         .|||| |||:|..|..         .|:
Zfish   249 CACPGRDRKADEDSIRKQHVTDGTKSSEAFRQASSHLSQLNSIKKRRSTDEEV---------FCL 304

  Fly   410 AIK 412
            .||
Zfish   305 PIK 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p53	NP_996267.1	P53	203..383	CDD:176262	53/216 (25%)
p53	NP_996267.1	P53_C	429..495	CDD:288471
tp63	NP_694518.1	P53	67..262	CDD:279242	61/258 (24%)
		P53_tetramer	292..332	CDD:285011	8/25 (32%)
		SAM_tumor-p63	449..513	CDD:188971
		SAM	453..513	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580495
Domainoid	1	1.000	66	1.000	Domainoid score	I9916
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002925
OrthoInspector	1	1.000	-	-		otm25509
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11447
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5172
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.930