Protein Alignment p53 and Tp53

DIOPT Version :10

• Sequence 1: NP_996267.1
• Gene: p53 / 2768677
• FlyBaseID: FBgn0039044
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_112251.2
• Gene: Tp53 / 24842
• RGDID: 3889
• Length: 391
• Species: Rattus norvegicus
• Alignment Length: 248
• Identity: 64/248 - (25%)
• Similarity: 109/248 - (43%)
• Gaps: 26/248 - (10%)

  Fly   187 ANTLPKLENHNIGGYCFSM--VLDEPPKS-LWMYSIPLNKLYIRMNKAFNVDVQFKSKMPIQPLN 248
            ::::|..:.:. |.|.|.:  :.....|| :..|||.||||:.::.|...|.:...|..| ....
  Rat    92 SSSVPSQKTYQ-GNYGFHLGFLQSGTAKSVMCTYSISLNKLFCQLAKTCPVQLWVTSTPP-PGTR 154

  Fly   249 LRVFLCF--SNDVSAPVVRCQNHLSVEPLTANNAKMRESLLRSE-NPNSVYCGNAQGKGISERFS 310
            :|....:  |..::..|.||.:|....  ..:.....:.|:|.| ||.:.|..:.|    :.|.|
  Rat   155 VRAMAIYKKSQHMTEVVRRCPHHERCS--DGDGLAPPQHLIRVEGNPYAEYLDDRQ----TFRHS 213

  Fly   311 VVVPLNMSRSVTRSGLTRQTLAFKFVCQNSCIG---RKETSLVFCLEKACGDIVGQHVIHVKICT 372
            ||||.    .....|....|:.:|::|.:||:|   |:....:..||.:.|:::|:....|::|.
  Rat   214 VVVPY----EPPEVGSDYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCA 274

  Fly   373 CPKRDRIQDERQLNSKKRKSVPEAAEEDEPSKVRRCIAIKTEDTESNDSRDCD 425
            ||.|||..:|.... ||.:..||.    .|...:|.:...|..:.....:..|
  Rat   275 CPGRDRRTEEENFR-KKEEHCPEL----PPGSAKRALPTSTSSSPQQKKKPLD 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p53	NP_996267.1	P53	193..385	CDD:459972	55/200 (28%)
		P53_C	429..495	CDD:314489
Tp53	NP_112251.2	Interaction with CCAR2. /evidence=ECO:0000250|UniProtKB:P04637	1..318		63/242 (26%)
		Transcription activation (acidic)	1..47
		P53_TAD	6..30	CDD:462520
		Interaction with WWOX. /evidence=ECO:0000250	64..108		3/16 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	65..90
		Interaction with HIPK1. /evidence=ECO:0000250	98..368		63/242 (26%)
		Required for interaction with ZNF385A. /evidence=ECO:0000250	98..298		59/216 (27%)
		P53	107..287	CDD:176262	53/190 (28%)
		Required for interaction with FBXO42. /evidence=ECO:0000250	111..234		34/133 (26%)
		Interaction with AXIN1. /evidence=ECO:0000250	114..290		52/187 (28%)
		Interaction with E4F1. /evidence=ECO:0000250	254..292		14/38 (37%)
		Interaction with DNA. /evidence=ECO:0000250	271..278		3/6 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..324		9/47 (19%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	303..319		2/15 (13%)
		Interaction with HIPK2. /evidence=ECO:0000250	317..358		1/6 (17%)
		P53_tetramer	317..356	CDD:462238	1/6 (17%)
		Oligomerization	323..354		64/248 (26%)
		Nuclear export signal. /evidence=ECO:0000250	337..348
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..391
		Interaction with USP7. /evidence=ECO:0000250	357..361
		Basic (repression of DNA-binding)	366..385
		[KR]-[STA]-K motif	368..370