DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p53 and Trp73

DIOPT Version :9

Sequence 1:	NP_996267.1	Gene:	p53 / 2768677	FlyBaseID:	FBgn0039044	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_006538783.2	Gene:	Trp73 / 22062	MGIID:	1336991	Length:	649	Species:	Mus musculus

Alignment Length:	412	Identity:	97/412 - (23%)
Similarity:	153/412 - (37%)	Gaps:	77/412 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 HKGTDSEDDSTEVDIKEDIPKTVEVSGSELTTEPMAFLQGLNSGNLMQ----------------- 168
            |..:..|.|||..|:.:....|.|.||||.:...:..|||:...||:.
Mouse    32 HLWSSLEPDSTYFDLPQPSQGTSEASGSEESNMDVFHLQGMAQFNLLSSAMDQMGSRAAPASPYT 96

  Fly   169 ------------FSQQSVLREMMLQDIQIQANT-LPKLENHNIGGYCFSMVLDE---PPKSLWMY 217
                        ::|.|...:.|.....|.:|| .|       |.:.|.:...:   ...:.|.|
Mouse    97 PEHAASAPTHSPYAQPSSTFDTMSPAPVIPSNTDYP-------GPHHFEVTFQQSSTAKSATWTY 154

  Fly   218 SIPLNKLYIRMNKAFNVDVQFKSKMPIQP-LNLRVFLCF--SNDVSAPVVRCQNHLSVEPLTANN 279
            |..|.|||.::.|  ...:|.|...|..| ..:|....:  :..|:..|.||.||..........
Mouse   155 SPLLKKLYCQIAK--TCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDIVKRCPNHELGRDFNEGQ 217

  Fly   280 AKMRESLLRSENPN-SVYCGNAQGKGISERFSVVVPLNMSRSVTRSGLTRQTLAFKFVCQNSCIG 343
            :.....|:|.|..| :.|..:.    ::.|.|||||.    ...:.|....|:.:.|:|.:||:|
Mouse   218 SAPASHLIRVEGNNLAQYVDDP----VTGRQSVVVPY----EPPQVGTEFTTILYNFMCNSSCVG 274

  Fly   344 ---RKETSLVFCLEKACGDIVGQHVIHVKICTCPKRDRIQDE------RQLN--SKKRKSVPEAA 397
               |:...::..||...|.::|:.....:||.||.|||..||      :.||  :.|..:..:.|
Mouse   275 GMNRRPILVIITLETRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESTTKNGAASKRA 339

  Fly   398 EEDEPSKVRRCIAIKTEDTESNDSRDCDDSAAEWNVSRTPDGDYRLAITCPNKEWLLQSIEGMIK 462
            .:..|.      ||....|.....|..|:.....:|.    |.....|....||.|  .:..::.
Mouse   340 FKQSPP------AIPALGTNVKKRRHGDEDMFYMHVR----GRENFEILMKVKESL--ELMELVP 392

  Fly   463 EAAAEVLRNPNQENLRRHANKL 484
            :...:..|...|:.|.:..:.|
Mouse   393 QPLVDSYRQQQQQQLLQRPSHL 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p53	NP_996267.1	P53	203..383	CDD:176262	52/195 (27%)
p53	NP_996267.1	P53_C	429..495	CDD:288471	10/56 (18%)
Trp73	XP_006538783.2	P53	137..316	CDD:176262	50/188 (27%)
		P53_tetramer	356..392	CDD:369476	8/41 (20%)
		SAM_tumor-p73	499..563	CDD:188970
		Gp37	558..>648	CDD:370600
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836964
Domainoid	1	1.000	65	1.000	Domainoid score	I9999
eggNOG	1	0.900	-	-		E1_2C1DX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43341
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11447
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5172
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.830