DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p53 and AgaP_AGAP004319

DIOPT Version :9

Sequence 1:	NP_996267.1	Gene:	p53 / 2768677	FlyBaseID:	FBgn0039044	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_313590.2	Gene:	AgaP_AGAP004319 / 1274462	VectorBaseID:	AGAP004319	Length:	410	Species:	Anopheles gambiae

Alignment Length:	318	Identity:	83/318 - (26%)
Similarity:	138/318 - (43%)	Gaps:	58/318 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 EDDSTEVDIKEDIPKTVE-------VSGSELTTEPMAFLQGLN-SGNLMQFSQQS-----VLREM 178
            :||:  :..:||:..|.|       :|...|....:...:.|| |...:..||.|     .|...
Mosquito     8 DDDA--IIAEEDMFATGEGCSQISFLSSQLLEDHILGLDKTLNDSSATLALSQTSPGVDIALPSS 70

  Fly   179 MLQDIQIQANTLPKLENHNIGGY------C-----FSMVLDEPPKSLWMYSIPLNKLYIRMNK-- 230
            :|||   ...:||...|.. |.|      |     |:::......|.:::|..|.||:::.:.
Mosquito    71 LLQD---GKGSLPSSLNPT-GKYPSVDELCPADIHFTVIPSSTQGSGFIFSEQLQKLFLKTDSIC 131

  Fly   231 AFNVDVQFKSKMPIQPLNLRVFLCFSNDVS-AP------VVRCQNHLSVEPLTANNAKMRESLLR 288
            :|::..|..:.:|.....:||.|     || ||      :.||..|::.:   ....::|:.::|
Mosquito   132 SFDIACQLPTFLPPTGWYVRVML-----VSLAPESQHESITRCHKHIAHD---TGPEEIRKHVVR 188

  Fly   289 SENPNSVYCGNAQGKGISERFSVVVPLNMSRSVTRSGLTRQTLAFKFVCQNSC--IGRKETSLVF 351
            .:|....|.|...|....:|::|.|||:......:       :..:|||||:|  :.::.|.|||
Mosquito   189 CKNEQHEYVGADNGPFFEDRYAVRVPLDDEVLCVK-------IMLQFVCQNTCFRLDQRRTGLVF 246

  Fly   352 CLEKACGDIVGQHVIHVKICTCPKRDRIQDERQLNSKKRKSVPEAAEEDEP--SKVRR 407
            .||...|:|..:.|:.||||...:||...::....:....|...|...|.|  |.|||
Mosquito   247 TLENDQGNIWARRVVPVKICINYRRDMQNEQNSAINFLPTSCLTAGRSDAPGTSAVRR 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p53	NP_996267.1	P53	203..383	CDD:176262	51/190 (27%)
p53	NP_996267.1	P53_C	429..495	CDD:288471
AgaP_AGAP004319	XP_313590.2	P53	106..280	CDD:176262	50/188 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C1DX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002925
OrthoInspector	1	1.000	-	-		otm50402
Panther	1	1.100	-	-	O	PTHR11447
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.870