DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p53 and taf1

DIOPT Version :9

Sequence 1:	NP_996267.1	Gene:	p53 / 2768677	FlyBaseID:	FBgn0039044	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_012824624.1	Gene:	taf1 / 100496377	XenbaseID:	XB-GENE-952372	Length:	1949	Species:	Xenopus tropicalis

Alignment Length:	242	Identity:	46/242 - (19%)
Similarity:	91/242 - (37%)	Gaps:	45/242 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 DSEDDSTEVDIKEDIPKTVEVSGSELTTEPMAFLQGLNSGNLMQFSQQSVLREMMLQDIQIQANT 189
            :.|::..:..|..|..:.::|.|:::..           |..:..|...|.|:.::  ::.....
Frog  1351 EQEEELEKTVIHNDNEELIKVEGTKIVL-----------GKQLIESADEVRRKSLV--LKFPKQQ 1402

  Fly   190 LPKLENHNIGGYCFSMVLDEPPKSLW-MYSIPLNKLYIRMNKAFNVDVQFKSKMPIQPLNLRVFL 253
            ||:.:...:|.......|:.|.||:. ..:.|:..|...:....|......:..|
Frog  1403 LPQKKKRRVGSTVHCDYLNRPHKSIHRRRTDPMVTLSSVLESIINDMRDMPNTYP---------- 1457

  Fly   254 CFSNDVSAPVVRCQNHLSVEPLTANNAKMRESLLRSENPNSVYCGNAQGKGISERFSVVVPLNMS 318
             |.:.|:|.||:....:.:.|:....  :||::.:...|:            .|.|...|.|.:.
Frog  1458 -FHSPVNAKVVKDYYKIVINPMDLQT--LRENVRKRMYPS------------REEFREAVELIVK 1507

  Fly   319 RSVTRSG----LTRQTLAFKFVCQNSCIGRKETSLVFCLEKACGDIV 361
            .|:..:|    ||:...|...:|:.. :..||..|. .||||...::
Frog  1508 NSILYNGPKHSLTQICQAMLELCEEK-LREKEDKLA-RLEKAINPLL 1552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p53	NP_996267.1	P53	203..383	CDD:176262	34/164 (21%)
p53	NP_996267.1	P53_C	429..495	CDD:288471
taf1	XP_012824624.1	TBP-binding	9..>41	CDD:286347
		DUF3591	596..1059	CDD:288969
		zf-CCHC_6	1314..1349	CDD:291934
		Bromo_TFIID	1438..1549	CDD:99943	29/137 (21%)
		Bromo_TFIID	1560..1671	CDD:99943
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C1DX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860