DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment p53 and tp73

DIOPT Version :10

Sequence 1:NP_996267.1 Gene:p53 / 2768677 FlyBaseID:FBgn0039044 Length:495 Species:Drosophila melanogaster
Sequence 2:XP_002933901.3 Gene:tp73 / 100496308 XenbaseID:XB-GENE-482857 Length:666 Species:Xenopus tropicalis


Alignment Length:378 Identity:93/378 - (24%)
Similarity:155/378 - (41%) Gaps:61/378 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 LPQSFG-NESNEYAHLATPVDPAYGGNNTNNMMQFTNNLEILANNNSDGNNKINACNKFVCHKGT 124
            :.||.| :|...:.||.:.::|    ::|...:..:::     :||::.:|:.:. |..|....|
 Frog    35 MSQSSGADEGTTFEHLWSTLEP----DSTYFELPQSSH-----SNNTEASNRTDV-NMDVYQMRT 89

  Fly   125 DSEDDSTEVDIKEDIPKTVEVS-GSE-LTTEPMAFLQGLNSGNLMQFSQQSVLREMMLQDIQIQA 187
            .:|...::.::   :..|::.| ||. .:|.|.......|......:||.|...:.|.....|.:
 Frog    90 MNESIMSQFNL---LNNTMDQSIGSRAASTSPYNPDHTSNVPTHSPYSQPSSTFDAMSPAPVIPS 151

  Fly   188 NT-LPKLENHNIGGYCFSMVLDE---PPKSLWMYSIPLNKLYIRMNKAFNVDVQFKSKMPIQPLN 248
            || .|       |.:.|.:...:   ...:.|.||..|.|||.::.|  ...:|.|...|..|.:
 Frog   152 NTDYP-------GTHNFEVTFQQSSTAKSATWTYSPLLKKLYCQIAK--TCPIQIKLSNPPPPGS 207

  Fly   249 -LRVFLCF--SNDVSAPVVRCQNHLSVEPLTANNAKMRESLLRSENPN-SVYCGNAQGKGISERF 309
             :|....|  :..|:..|.||.||..........|.....|:|.|..| |.|..:.    ::.|.
 Frog   208 VIRAMPVFKKAEHVTEVVKRCPNHELGRDFNDGQAAPASHLIRVEGNNLSQYVDDP----VTGRQ 268

  Fly   310 SVVVPLNMSRSVTRSGLTRQTLAFKFVCQNSCIG---RKETSLVFCLEKACGDIVGQHVIHVKIC 371
            ||:||.    ...:.|....|:.:.|:|.:||:|   |:...::..||...|.::|:.....:||
 Frog   269 SVMVPY----EPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLETRDGQVLGRRSFEGRIC 329

  Fly   372 TCPKRDRIQDE--------------RQLNSKKR---KSVPEAAEEDEPSKVRR 407
            .||.|||..||              :..|:.||   :|.|.........|.||
 Frog   330 ACPGRDRKADEDHFREQAALNETAAKNGNANKRTFKQSPPSVPSMGSNIKKRR 382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
p53NP_996267.1 P53 193..385 CDD:459972 55/215 (26%)
P53_C 429..495 CDD:314489
tp73XP_002933901.3 P53 161..343 CDD:176262 54/191 (28%)
P53_tetramer 379..418 CDD:462238 3/4 (75%)
SAM_tumor-p73 521..585 CDD:188970
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.